INTRAVENOUS METHYLPREDNISOLONE VS ORAL PREDNISOLONE IN TRANSPLANT REJECTION

静脉注射甲基泼尼松龙与口服泼尼松龙在移植排斥中的比较

• 批准号: 7374506
• 负责人: GREGORY M TIAO
• 金额: $ 0.06万
• 依托单位: CINCINNATI CHILDRENS HOSP MED CTR
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-12-01 至 2006-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7374506
• 关键词: INTRAVENOUS; METHYLPREDNISOLONE; VS; ORAL; PREDNISOLONE

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The trial comparing intravenous methlyprednisolone versus oral prednisolone in the treatment of acute rejection in pediatric liver transplant recipients continues. We are comparing the effect of oral versus iv steroids in an effort to improve the patients quality of life and to reduce medical costs. In the past, all children who had acute rejection following liver transplantation required one week hospitalization. This is disruptive to their day to day life and has an impact on medical costs. The bioavailability of orally administered steroids is similar to those given intravenously therefore we hypothesized both treatments are effective. To ensure patient safety, we began this small study to test that hypothesis. Our study endpoints are control of acute rejection, improved quality of life as assessed by an outcomes questionnaire and decreased medical cost.

该子项目是利用 NIH/NCRR 资助的中心拨款提供的资源的众多研究子项目之一。子项目和研究者 (PI) 可能已从另一个 NIH 来源获得主要资金，因此可以在其他 CRISP 条目中出现。列出的机构是中心的机构，不一定是研究者的机构。比较静脉注射甲泼尼龙与口服泼尼松龙治疗小儿肝移植受者急性排斥反应的试验仍在继续。我们正在比较口服类固醇与静脉注射类固醇的效果，以期改善患者的生活质量并降低医疗费用。过去，所有肝移植后出现急性排斥反应的儿童都需要住院一周。这扰乱了他们的日常生活，并影响了医疗费用。口服类固醇的生物利用度与静脉注射类固醇相似，因此我们假设两种治疗方法都是有效的。为了确保患者安全，我们开始了这项小型研究来检验这一假设。我们的研究终点是控制急性排斥反应、通过结果调查问卷评估改善生活质量以及降低医疗费用。