EFFECT OF NOVEL ANDROGENS ON ECTOPIC ENDOMETRIUM IN RHESUS MACAQUES

新型雄激素对恒河猴异位子宫内膜的影响

• 批准号: 8173298
• 负责人: OV D SLAYDEN
• 金额: $ 9.51万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-05-01 至 2011-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8173298
• 关键词: Adverse effects; Androgen Therapy; Androgens; Biological Models; Computer Retrieval of Information on Scientific Projects Database; Dose; Endometrial; Endometrium; Estrogens; Fatty acid glycerol esters; Female; Funding; Goals; Grant; Growth; Institution; Intra-abdominal; Liver; Macaca; Macaca mulatta; Methods; Pharmacotherapy; Preclinical Testing; Research; Research Personnel; Resources; Site; Source; Stanolone; Testing; Testosterone; Tissues; Transplantation; United States National Institutes of Health; Woman; analog; endometriosis; novel; subcutaneous

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Our goal is to investigate new drug therapies for endometriosis. Macaque endometrium can be auto-transplanted to ectopic intra-abdominal and subcutaneous sites. These endometrial grafts provide an excellent endometriosis-like model system for preclinical testing of novel anti-endometriotic therapies. Bayer Schering Pharma (BSP) is developing a testosterone analog (eF-MENT) that exerts higher androgenic activity than testosterone and is not converted to estrogens by the liver and fat tissues. In this study we will test the effect of eF-MENTon estrogen stimulated growth in endometrial grafts, and compare the effects of eF-MENT with the effects of dihydrotestosterone (DHT a natural androgen) as a positive control. This study has two aims: Aim 1 is to develop methods to identify nonreproductive "off-target" effects of androgens in female macaques that are analogous to the side effects of androgen therapy in women. Aim 2 is to determine if eF-MENT therapy will inhibit growth in ectopic endometrium in rhesus macaques. Dose finding studies with eF-MENT are underway.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 我们的目标是研究用于子宫内膜异位症的新药物疗法。 猕猴可以自动转移至异位 腹内和皮下部位。 这些子宫内膜移植物为新型抗内膜疗法的临床前测试提供了出色的子宫内膜异位症模型系统。 Bayer Schering Pharma（BSP）正在开发一种睾丸激素类似物（EF-Mentog），该睾丸激素比睾丸激素具有更高的雄激素活性，并且不会被肝脏和脂肪组织转化为雌激素。 在这项研究中，我们将测试Ef-entryon雌激素刺激子宫内膜移植物的生长的作用，并将EF-Ment的影响与二氢睾丸激素（DHT天然雄激素）的作用进行比较为阳性对照。 这项研究有两个目的：目标1是开发方法来鉴定雄激素在女性猕猴中的非生殖“脱靶”作用，这些作用类似于女性雄激素治疗的副作用。 目标2是确定恒河猕猴异位子宫内膜的生长是否会抑制EF-Ment疗法。剂量发现研究正在进行中。