STUDIES OF AGING AND COGNITION IN NONHUMAN PRIMATES

非人类灵长类动物的衰老和认知研究

• 批准号: 8172302
• 负责人: JAMES G HERNDON
• 金额: $ 5.48万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-05-01 至 2011-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8172302
• 关键词: Age; Aging; Behavioral; Brain; Cognition; Cognitive; Collection; Computer Retrieval of Information on Scientific Projects Database; Data; Ensure; Funding; Grant; Health; Impaired cognition; Institution; Intervention; Investigation; Macaca mulatta; Magnetic Resonance Imaging; Monkeys; Pattern; Phase; Phenotype; Research; Research Personnel; Resources; Short-Term Memory; Source; United States National Institutes of Health; Visual; aged; executive function; memory recognition; middle age; nonhuman primate; relating to nervous system

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The objective of project was to characterize the aging behavioral phenotype in the rhesus monkey and determine which neural changes are correlated with specific behavioral declines. An initial phase of the study involved the collection of baseline health data, including ophthalmic examinations and magnetic resonance images of the brain, to ensure that the monkeys are not diseased so that any behavioral deficits that may be identified are attributable to normal cognitive decline. The application of well-characterized behavioral tasks taps specific cognitive domains, including visual recognition memory, spatial working memory, and executive function. We successfully identified changes in cognition that are typical of aging as well as changes in the brain that accompany behavioral decline. A key overall finding of this study was that some aged monkeys appear to be spared from serious cognitive losses, while others are markedly impaired. Our current approach to investigation of these different patterns is to focus on middle age, when changes are just beginning to occur. This characterization of which monkeys are likely to progress to worsened cognition and which are likely to remain unimpaired will assist us in delineating optimal strategies for mid-life interventions.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 该项目的目标是表征恒河猴的衰老行为表型，并确定哪些神经变化与特定行为下降相关。 研究的初始阶段涉及收集基线健康数据，包括眼科检查和大脑磁共振图像，以确保猴子没有患病，以便任何可能发现的行为缺陷都可归因于正常的认知能力下降。 明确特征的行为任务的应用可以挖掘特定的认知领域，包括视觉识别记忆、空间工作记忆和执行功能。 我们成功地识别了衰老过程中典型的认知变化以及伴随行为下降而发生的大脑变化。 这项研究的一个关键总体发现是，一些老年猴子似乎没有遭受严重的认知丧失，而另一些则明显受损。 我们目前研究这些不同模式的方法是关注中年，此时变化才刚刚开始发生。 哪些猴子的认知能力可能会恶化，哪些猴子可能不会受到损害，这种特征将有助于我们制定中年干预的最佳策略。