Physico-Chemical Nanocharacterization Core

物化纳米表征核心

基本信息

批准号：
7984285
负责人：
SRINIVAS SRIDHAR
金额：
$ 9.53万
依托单位：
NORTHEASTERN UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
起止时间：
2010-09-01 至 2015-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7984285
关键词：
Adsorption Algorithms Antineoplastic Agents Area Atomic Force Microscopy Basic Science Biodistribution Blood Buffers CCNE1 gene Characteristics Charge Chemicals Databases Defense Mechanisms Dendrimers Drug Formulations Engineering Feedback Fluorescence Genes Laboratories Lipids Liposomes Malignant Neoplasms Measurement Micelles Microscopic Microscopy Mission Morphology Multi-Drug Resistance Nanotechnology Optics Pharmaceutical Preparations Plasma Production Property Reporting Research Personnel Resolution Role Sampling Scanning Electron Microscopy Scientist Small Interfering RNA Spectrum Analysis Staging Surface System Testing Translating Transmission Electron Microscopy Variant Work analytical tool base cancer cell cancer therapy chemical property design manufacturing scale-up nano nanocarrier nanomedicine nanoparticle nanosystems novel pre-clinical research clinical testing tumor ultraviolet

项目摘要

PHYSICO-CHEIVIICAL NANOCHARACTERIZATION CORE . The role of this core will be to provide the necessary physico-chemical characterization of nanopreparations such as polymeric nanoparticles, lipid nanoparticles, dendrimers, and selfassembling nanosystems prepared in all the CCNE projects. An array of sophisticated microscopic, spectroscopic and analytical tools are available to study the size, size distribution, stability, surface charge, and drug loading/release from these nanopreparations. This core brings expertise in the basic science and engineering aspects of nanotechnology that is essential to understand the fundamental properties of these nanopreparations. Feedback from this core will help the scientists engaged in these projects to optimize these nanopreparations for successful use in cancer therapy. This core will also work in parallel with Nano Characterization Laboratory (NCL) to facilitate the overall mission of this CCNE to translate basic research to industrial production of nanomedicines.

物理化学纳米表征核心。该核心的作用是提供必要的物理化学表征所有 CCNE 项目中制备的纳米制剂，例如聚合物纳米颗粒、脂质纳米颗粒、树枝状聚合物和自组装纳米系统。一系列复杂的显微镜、光谱和分析工具可用于研究这些纳米制剂的尺寸、尺寸分布、稳定性、表面电荷和药物加载/释放。该核心带来了纳米技术基础科学和工程方面的专业知识，这对于理解这些纳米制剂的基本特性至关重要。来自该核心的反馈将帮助参与这些项目的科学家优化这些纳米制剂，以成功用于癌症治疗。该核心还将与纳米表征实验室 (NCL) 并行工作，以促进 CCNE 的总体使命，将基础研究转化为纳米药物的工业生产。