Autonomic Control of Body Weight and Feeding

体重和进食的自主控制

• 批准号: 8006874
• 负责人: TERRY L. POWLEY
• 金额: $ 4万
• 依托单位: PURDUE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-01-01 至 2010-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8006874
• 关键词: Animal Model; Axon; Body Weight; Brain; Bypass; Digestive System Disorders; Disease; Duodenum; Eating Disorders; Equipment and supply inventories; Feeding behaviors; Foundations; Goals; Homeostasis; Implant; Ingestion; Intervention; Intestines; Investigation; Irritable Bowel Syndrome; Link; Maps; Metabolic; Motor; Mutation; Natural regeneration; Nerve; Neural Pathways; Neurosciences; Obesity; Operative Surgical Procedures; Pacemakers; Peptic Ulcer; Physiology; Protocols documentation; Reflux; Regulation; Sensory; Series; Stomach; Structure; Tracer; Vagus nerve structure; Visceral; Visceral Afferents; Visceral pain; autonomic neuropathy; bariatric surgery; design; feeding; gastrointestinal; nerve supply; neuromechanism; obesity treatment; receptor; relating to nervous system; research study

The proposed project continues a programmatic investigation of the neural mechanisms of feeding and body weight regulation. The long-range goal of the project is to provide information needed for treating ingestive disorders, notably obesity, and a variety of gastrointestinal (Gl)diseases. The vagus nerve is the major neural pathway reciprocally connecting the brain and the Gl tract. Vagal sensory and motor axons coordinate much of the physiology of energy homeostasis, including both short-term and long-term controls of ingestion and body weight. Surprisingly, given the crucial importance of the vagus, many of the nerve's structural and functional features particularly relevant to an adequate understanding of ingestion are as yet undescribed. Thus, the immediate goal of the project is to conduct a series of promising analysesthat are characterizing the morphological types, regional distributions, and functions of vagal projections that link the brain and Gl tract. The first specific aim is to characterize and map the different vagal~and other visceral- sensory endings in the stomach. The second specific aim is to describe and map the vagal-and other visceral-sensory endings in the intestines. The experiments of these first two aims will use recently adapted neural tracer protocols to provide inventories of, and maps for, the chemo-, mechano-, osmo-, and thermo- receptors throughout the gut.The third aim is to characterize and map different vagal motor projections to the Gl tract. This third series of experiments will use tracers to yield an inventory of, and maps for,the motor projections by which the brain coordinates Gl functions. The final aim is to evaluate alterations in ingestive behavior associated with selective structural changes in the innervation of the Gl tract. The experiments of this aim will use structure-function correlations in animal models involving vagus nerve transections and regeneration, vagal losses produced by selective mutations, and surgical manipulations of the stomach and duodenum. The aims are critically relevant to developing treatments for obesity and other metabolic and digestive diseases. The proposed experiments will generate a more adequate neuroscience foundation for refining obesity surgeries (e.g., bypasses and pacemaker implants), now designed primarily through trial and error, and other interventions of the Gl tract that are used in the treatment of eating disorders, reflux disease, irritable bowel syndrome, peptic ulcers, autonomic neuropathies, and visceral pain.

拟议的项目继续对喂养和身体的神经机制进行编程调查 体重调节。该项目的远程目标是提供治疗摄入剂所需的信息 疾病，尤其是肥胖症和各种胃肠道（GL）疾病。迷走神经是专业 神经途径相互连接大脑和GL道。迷走性感觉和运动轴突 协调能量稳态的大部分生理学，包括短期和长期控制 摄入和体重。令人惊讶的是，鉴于迷走神经的重要性，许多神经 与对摄入的充分理解特别相关的结构和功能功能尚未 未描述。因此，该项目的直接目标是进行一系列有希望的分析是 表征与关联的迷走神经投影的形态类型，区域分布和功能 大脑和GL道。第一个具体目的是表征和绘制不同的迷走神经和其他内脏 - 胃中的感官结局。第二个特定目的是描述和映射迷走神经和其他 肠内内脏感官的结尾。前两个目标的实验将最近使用 神经示踪剂方案，可提供化学，机械，osmo-和Thermo-的清单和地图 整个肠道的受体。第三个目的是将不同的迷走运动投影表征和映射到 GL道。第三个系列实验将使用示踪剂来产生电动机的清单和地图 大脑协调GL功能的投影。最终目的是评估摄入剂的改变 与选择性结构变化有关的行为在GL道的神经上变化。实验 该目标将在涉及迷走神经式型和的动物模型中使用结构功能相关性 再生，选择性突变产生的迷走神经损失以及对胃和胃的手术操作 十二指肠。目的与开发肥胖和其他代谢和其他代谢的疗法至关重要 消化疾病。提出的实验将为 精炼肥胖手术（例如，绕过和起搏器植入物），现在主要是通过试验设计的 误差以及用于治疗饮食失调，反流疾病的GL道的其他干预措施， 肠易激综合征，消化性溃疡，自主神经病和内脏疼痛。