In utero and neonatal effects of triclocarban exposure

三氯卡班暴露对子宫内和新生儿的影响

基本信息

批准号：
8150452
负责人：
JIANGANG CHEN
金额：
$ 22.4万
依托单位：
UNIVERSITY OF TENNESSEE KNOXVILLE
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
起止时间：
2010-09-27 至 2014-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8150452
关键词：
Accessory Sex Organs Address Adult Adverse effects Androgens Animals Attention Biological Categories Chemosensitization Development Disease Embryo Endocrine Endocrine Disruptors Endocrine disruption Environmental Risk Factor Estrogens Etiology Evaluation Exhibits Exposure to Female Foundations Future Gonadal Steroid Hormones Growth Health Hormones Human In Vitro International Investigation Laboratories Ligands Measures Motivation Neonatal Organ Outcome Pregnancy Property Puberty Rattus Relative (related person)Reproductive Health Resources Risk Rodent Rodent Model Self Care Sex Differentiation Sexual Development Soil Staging Time Tissues Water Xenobiotics antimicrobial design dietary supplements exposed human population in utero in vivo interest male neonatal exposure novel placental transfer postnatal public health relevance reproductive small molecule symposium triclocarban

项目摘要

DESCRIPTION (provided by applicant): Triclocarban (TCC) has recently been described as a new type endocrine disruptor substance (EDS). Human exposures to TCC are quite broad since this compound is a common additive to personal care products for its antimicrobial properties. In vitro and in vivo studies show that TCC augments the action of sex steroid hormones on adult target tissues with no or little bioactivity on its own. In vivo studies demonstrate that a diet supplemented with TCC (0.25% w/w for ten days) increases accessory sex organ growth by 50 - 200% when administered to adult male rats. Furthermore, circulating TCC levels attained are similar to levels measured in humans following normal daily use of common personal care products. However, limited information is available regarding its potential impact on reproductive health during in utero and/or neonatal exposure. These time periods are the most important and sensitive intervals for sexual differentiation and sex organ development. There is increasing concern over embryonic determinants of adult health and the present proposal is designed to investigate placental transfer and effect of dietary TCC exposure on a rodent dam. Specifically, this application proposes to quantify placental transfer and determine the relative adverse effects of exposure to this novel EDS on reproductive tract development at two different sensitive periods in the rodent model. We hypothesize that exposure to TCC in both exposure periods will accelerate or accentuate the maturation of reproductive tract in both males and females. The results from the proposal will provide pivotal information on the adverse effects of TCC on sexual development and foundation information for new avenues of exploration into the etiology of many sex hormone associated disorders that have not been explained by investigations of conventional EDS. PUBLIC HEALTH RELEVANCE: The recent finding that TCC has novel endocrine disruptor properties raises the possibility that daily exposures during pregnancy to TCC may have a wide range of adverse health effects. Animal studies indicate that accessory sex organs are enlarged by TCC exposure and suggest a potential adverse effect on sexual differentiation and organ development. This proposal will address the increasing concern over embryonic determinants of adult health resulting from environmental factors and provide guidance for future investigations of the health risk from in utero and neonatal TCC exposure.

描述（由申请人提供）：Triclocarban（TCC）最近被描述为一种新型内分泌干扰物物质（EDS）。人类对TCC的接触非常广泛，因为该化合物是其抗菌特性的个人护理产品的常见添加剂。体外和体内研究表明，TCC可以单独使用无或少量生物活性，从而增强了性类固醇激素对成人靶组织的作用。体内研究表明，补充TCC的饮食（十天0.25％w/w）将辅助性和性器官的生长增加50-200％。此外，达到的循环TCC水平类似于正常使用普通个人护理产品后人类测量的水平。但是，在子宫内和/或新生儿暴露期间，有关其对生殖健康的潜在影响的信息有限。这些时间段是性别分化和性器官发展的最重要，最敏感的间隔。人们对成人健康的胚胎决定因素越来越关注，本提案旨在研究胎盘转移和饮食中TCC对啮齿动物大坝的影响。具体而言，该应用建议量化胎盘转移并确定啮齿动物模型中两个不同敏感时期的生殖道发育中对这种小说ED的相对不利影响。我们假设在两个暴露期间暴露于TCC将加速或强调男性和女性的生殖道的成熟。该提案的结果将提供有关TCC对性发展和基础信息的不利影响的关键信息，以探索对许多性激素相关疾病的病因的新途径，而这些疾病尚未通过常规ED的研究来解释。公共卫生相关性：最近的发现TCC具有新颖的内分泌破坏性特性，这增加了一种可能性，即怀孕期间每天接触TCC可能会产生广泛的不良健康影响。动物研究表明，辅助性器官会因TCC暴露而扩大，并暗示对性分化和器官发育产生潜在的不利影响。该提案将解决对环境因素导致成人健康的胚胎决定因素的越来越多的关注，并为未来对子宫和新生儿TCC暴露的健康风险进行调查提供了指导。

项目成果

期刊论文数量（2）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Extraction of 3,4,4'-Trichlorocarbanilide from Rat Fecal Samples for Determination by High Pressure Liquid Chromatography-Tandem Mass Spectrometry.

DOI：
10.3390/ijerph120708125
发表时间：
2015-07-15
期刊：
International journal of environmental research and public health
影响因子：
0
作者：
Kennedy RC;Fling RR;Terry PD;Menn FM;Chen J;Borman CJ
通讯作者：
Borman CJ

Temporal Development of Gut Microbiota in Triclocarban Exposed Pregnant and Neonatal Rats.

DOI：
10.1038/srep33430
发表时间：
2016-09-20
期刊：
Scientific reports
影响因子：
4.6
作者：
Kennedy RC;Fling RR;Robeson MS;Saxton AM;Donnell RL;Darcy JL;Bemis DA;Liu J;Zhao L;Chen J
通讯作者：
Chen J