Affective Neuroscience of Schizophrenia and Bipolar Disorder

精神分裂症和双相情感障碍的情感神经科学

基本信息

批准号：
8114243
负责人：
WILLIAM P. HORAN
金额：
$ 17.51万
依托单位：
BRENTWOOD BIOMEDICAL RESEARCH INSTITUTE
依托单位国家：
美国
项目类别：
财政年份：
2011
资助国家：
美国
起止时间：
2011-08-01 至 2013-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8114243
关键词：
Affective Anhedonia Applications Grants Arousal Auditory Benchmarking Biological Markers Bipolar Disorder Blinking Classification Clinical Communities Cues Diagnosis Diagnostic Discrimination Disease Emotional Emotional Disturbance Emotions Event-Related Potentials Funding Goals Impairment Incentives Individual Differences Measures Mental disorders Methods Moods National Institute of Mental Health Neurosciences Research Outcome Outpatients Patient Self-Report Patients Pattern Peripheral Peripheral Nervous System Physiological Process Psychotic Disorders Punishment Reaction Time Recording of previous events Recruitment Activity Research Resistance Rewards Schizophrenia Signal Transduction Stimulus Symptoms System Testing affective neuroscience attenuation base clinical phenotype comparison group disability emotional stimulus endophenotype expectation indexing novel pleasure psychosocial research study response severe mental illness therapy development trait

项目摘要

DESCRIPTION (provided by applicant): Schizophrenia (SCZ) and bipolar disorder-I (BPD) have many similarities, but they have notably different emotional response profiles to appetitive stimuli, and these are present even among clinically stable patients. The goal of this R21 application is to apply current affective neuroscience methods to understand the underlying processes for these different emotional response profiles. We will test hypotheses that stable outpatients with SCZ and euthymic BPD-I patients with a history of psychosis will demonstrate opposite central and peripheral nervous system responses to rewarding stimuli during two types of tasks: affective chronometry, which refers to the temporal parameters (e.g., anticipation, offset) of emotional responding, and motivational engagement, which refers to mobilization of physiological response systems during impending rewards and punishments. 35 SCZ outpatients, 35 euthymic BPD outpatients, and 35 matched healthy controls will complete the two types of paradigms while simultaneous ERP and startle eye blink responses are recorded. Affective chronometry will be measured with a passive emotional picture viewing task with startle probes before, during, and after picture presentation. Motivational engagement will be measured with an active motivational gradient task, in which cues signaling reward or punishment appear to loom progressively closer to the viewer. We predict SCZ patients will demonstrate hypo-reactivity and BPD patients will show hyper-reactivity for specific physiological responses to positive stimuli. Identification of emotional disturbances that are uniquely associated with SCZ and BPD would have direct implications for treatment development and identification of novel endophenotypes. PUBLIC HEALTH RELEVANCE: Schizophrenia (SCZ) and bipolar disorder-I (BPD) are two of the most severely disabling psychiatric disorders, and recent evidence suggests that notably different emotional response abnormalities contribute to poor outcome within each disorder. The goal of this R21 exploratory grant application is to apply affective neuroscience methods to test the hypothesis that stable outpatients with SCZ or BPD-I with a history of psychosis (in a euthymic mood state) will demonstrate differential central and peripheral nervous system responses during tasks that index affective chronometry and motivational engagement. Identification of emotional disturbances that are uniquely associated with each disorder would have direct implications for treatment development and novel emotional endophenotypes.

描述（由申请人提供）：精神分裂症（SCZ）和双相情感障碍-I（BPD）具有许多相似之处，但它们对食用性刺激的情绪反应概况明显不同，即使在临床上稳定的患者中，它们也存在。该R21应用的目的是应用当前的情感神经科学方法来了解这些不同的情绪响应概况的基本过程。我们将检验假设，即具有精神病史的SCZ和Hechymic BPD-I患者的稳定门诊病人将在两种任务中表现出对面的中心和周围神经系统对奖励刺激的反应：情感时间表：情感参数（例如，在情绪响应过程中）对动机的响应和刺激性的反应，这是对动机的响应，并指出了刺激性的态度。奖励和惩罚。 35个SCZ门诊病人，35个正式BPD门诊病人和35个匹配的健康对照组将完成两种类型的范例，同时记录ERP和惊吓眼睛的眨眼反应。情感计时率将通过在图片演示之前，之中和之后使用惊吓探针进行被动的情感图片观看任务来衡量。动机参与将通过一项积极的动机梯度任务来衡量，在该任务中，提示信号奖励或惩罚似乎逐渐与观众更加接近。我们预测，SCZ患者将证明发病率发育不良，而BPD患者将显示出对阳性刺激的特定生理反应的过度反应性。与SCZ和BPD唯一相关的情绪障碍的识别将对治疗开发和新型内表型的鉴定有直接影响。公共卫生相关性：精神分裂症（SCZ）和双相情感障碍I（BPD）是两个最严重的精神疾病，最近的证据表明，尤其是不同的情绪反应异常在每种疾病中导致不良结果。该R21探索性赠款应用的目的是应用情感神经科学方法来检验以下假设：具有SCZ或BPD-I具有精神病史的稳定的门诊病人（在精神分子的情绪状态下）表现出差异性中心和外围性神经系统反应，这些任务是在任务中进行情感评分和动机参与的任务。与每种疾病唯一相关的情绪障碍的识别将对治疗发展和新型情绪内表型产生直接影响。