Mechanisms of skeletal muscle adaptation in COPD

COPD 中骨骼肌的适应机制

• 批准号: 8150135
• 负责人: PETER D WAGNER
• 金额: $ 62.17万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-12-01 至 2013-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8150135
• 关键词: Acids; Acute; Address; Angiogenic Factor; Angiopoietin-2; Animals; Antioxidants; Apoptosis; Area; Attenuated; Biopsy; Biopsy Specimen; Blood Vessels; Blood capillaries; Blood flow; Budgets; C-reactive protein; Cachexia; Capillarity; Carbon Dioxide; Cardiac; Cardiopulmonary; Chronic Obstructive Airway Disease; Chronic lung disease; Citrate (si)-Synthase; Comorbidity; Complement; Coupled; Crossbreeding; DEXA; Data; Dimensions; Dobutamine; Dose; Echocardiography; Environmental air flow; Enzymes; Equilibrium; Exercise; Fatigue; Fiber; Fibroblast Growth Factor 2; Functional disorder; Gastrocnemius Muscle; Gene Deletion; Genes; Heart; Histologic; Housing; Human; Human Resources; Hypercapnia; Impairment; In Situ; In Vitro; Individual; Inflammation; Inflammation Mediators; Inflammatory; Inflammatory Response; Interleukin-6; Knee; Lead; Left; Leg; Lung; Magnetic Resonance Imaging; Measurement; Measures; Mediator of activation protein; Messenger RNA; Metabolic; Mitochondria; Modeling; Molecular; Morphology; Mus; Muscle; Muscle Cells; Muscle Fibers; Muscle function; Myocardium; Organ; Oxidative Stress; Oxidative Stress Pathway; Pathway interactions; Patients; Performance; Phenotype; Physical activity; Physiologic intraventricular pressure; Physiological; Plethysmography; Process; Production; Proteins; Pulmonary Emphysema; Pulmonary Surfactant-Associated Protein C; Research; Research Methodology; Research Personnel; Respiratory Diaphragm; Rest; Running; Severity of illness; Skeletal Muscle; Speed; Stratification; Structure; Study Subject; Superoxides; Supplementation; Techniques; Testing; Thioctic Acid; Tidal Volume; Time; Training; Transfer Agreement; Transgenic Mice; Transgenic Organisms; Vascular Endothelial Growth Factors; Ventricular; Vitamin E; Work; age difference; angiogenesis; antioxidant therapy; awake; base; capillary; catalase; density; exhaustion; experience; improved; in vivo; indexing; mRNA Expression; morphometry; mouse Cre recombinase; mouse model; muscle form; overexpression; programs; promoter; protein expression; respiratory; response; sciatic nerve; skeletal; stem; wasting