Tim Upgrade for Nonhuman-Primate-Dedicated Magnetom Trio

蒂姆升级非人类灵长类专用磁力三重奏

• 批准号: 7792912
• 负责人: Christopher D Kroenke
• 金额: $ 50万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-05-13 至 2011-05-12
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7792912
• 关键词: 7 year old; Algorithms; Award; Clinical Research; Computer software; Development; Equipment and supply inventories; Failure; Fatigue; Funding; Future; Generations; Health Sciences; Human; Image; Institution; Investigation; Knowledge; Lead; Magnetic Resonance Imaging; Manufacturer Name; Measurement; Medical; Methodology; Microscopic; Operative Surgical Procedures; Oregon; Pathology; Physiologic Monitoring; Primates; Procedures; Process; Protocols documentation; Research; Research Project Grants; Research Subjects; Signal Transduction; Structure; System; Time; Tissues; Translational Research; Universities; base; clinical practice; computerized data processing; design; human subject; improved; instrument; instrumentation; nonhuman primate; public health relevance; repaired; research and development; research study; software systems; square foot; water diffusion

DESCRIPTION (provided by applicant: The Oregon National Primate Research Center (ONPRC) maintains a free-standing, 2,500 sq. ft. magnetic resonance imaging (MRI) facility that is within 100 ft. of the ONPRC surgical space, and is dedicated to the study of nonhuman primate subjects. This arrangement enables MRI-based investigations to be interfaced with virtually any ongoing research project at the ONPRC. Technical oversight of the ONPRC MRI facility is provided by the Oregon Health & Science University (OHSU) Advanced Imaging Research Center (AIRC). Through this cooperative endeavor, a number of nonhuman-primate-based MRI investigations are leading to the development of several new imaging strategies for monitoring physiological and anatomical processes that underlie primate pathology and development. Each of these experiments is potentially of direct translational value to current clinical research. At the time of award, the ONPRC Siemens MAGNETOM 3T Trio MRI system will be seven years old. Due to instrumentation fatigue over long-term use, system failures are becoming more frequent, and repair times are lengthier due to the manufacturer's smaller inventory of replacement parts for machines of this vintage. In this application, funds are being requested for a "Total imaging matrix" (Tim) upgrade to the ONPRC MRI system. Several recent technological developments in the ability to perform simultaneous acquisition of multiple receiver channels have stimulated MRI system manufacturers to substantially modify hardware designs. Current MRI systems differ from the ONPRC system by possessing more extensive "parallel imaging" capabilities. They can integrate a larger number signal input channels, and apply improved data processing algorithms to synthesize images. Additionally, improvements in gradient coil design have lead to the ability to more rapidly acquire images in dynamic experiments, and additionally improve measurements of water diffusion - a powerful methodology for characterizing tissue structure on the microscopic level. Within the context of the ONPRC/AIRC arrangement, an upgrade of the MRI system will greatly facilitate translational research by enabling sharing of protocols between the nonhuman primate MRI system and the AIRC's human Tim MRI systems located on the OHSU main campus (10 miles east of the ONPRC campus). Currently, image acquisition and processing procedures developed at OHSU and other research institutions system cannot be shared between systems due to inherent incompatibilities in software and hardware configurations of Tim and non-Tim instruments. As a result, most technological research and development occurs within the framework of Tim-generation systems. The requested funds will facilitate realization of the full translational potential of the ONPRC MRI system. PUBLIC HEALTH RELEVANCE: Funds are requested for the upgrade of an MRI system that is located on the Oregon National Primate Research Center (ONPRC) campus, and is dedicated to the study of nonhuman primate research subjects. Most nonhuman primate research focuses on the development of medical knowledge that can be used to direct future clinical practice. The requested upgrade will equip the ONPRC MRI system with improved hardware and software systems that will enable measurements performed on it to be identical to those performed on MRI systems used to examine human subjects.

描述（由申请人提供：俄勒冈州国家灵长类动物研究中心（ONPRC）维持自由的2,500平方英尺的磁共振成像（MRI）设施，该设施在ONPRC手术空间的100英尺范围内，专门用于非人类灵长类动物的研究，该安排对基于MRI的研究进行了研究。 ONPRC MRI设施由俄勒冈州健康与科学大学（OHSU）通过这项合作的努力提供了高级成像研究中心（AIRC）。奖项，ONPRC SIEMENS MAGNETOM 3T三重奏MRI系统将为7岁。由于仪器疲劳在长期使用时，系统故障变得越来越频繁，并且由于制造商较小的替换零件的库存库存较小，因此维修时间更长。在此应用程序中，要求资金“总成像矩阵”（TIM）升级到ONPRC MRI系统。在执行多个接收器渠道同时获得的能力方面，最近的一些技术发展刺激了MRI系统制造商实质上修改了硬件设计。当前的MRI系统与ONPRC系统不同，通过具有更广泛的“并行成像”功能。他们可以集成更大的数字信号输入通道，并将改进的数据处理算法应用于合成图像。此外，改进梯度线圈设计可以使能够在动态实验中更快地获取图像，并改善水扩散的测量 - 一种表征显微镜水平组织结构的强大方法。在ONPRC/AIRC安排的背景下，MRI系统的升级将通过实现非人类灵长类动物MRI系统和位于OHSU MAIN校园（OHSU MAIN校园（ONPRC校园东部10英里）的AIRC人类TIM MRI系统之间的协议共享，从而极大地促进了转化研究。当前，由于软件和非TIM Instruments的软件和硬件配置中的固有不兼容，在系统之间开发的图像采集和处理程序无法共享系统之间的其他研究机构系统。结果，大多数技术研发都发生在Tim-Generation系统的框架内。要求的资金将有助于实现ONPRC MRI系统的全部翻译潜力。 公共卫生相关性：要求资金升级位于俄勒冈州国家灵长类动物研究中心（ONPRC）校园的MRI系统，并致力于研究非人类灵长类动物研究对象。大多数非人类灵长类动物研究都集中于可以用来指导未来临床实践的医学知识的发展。所需的升级将使ONPRC MRI系统配备改进的硬件和软件系统，这些硬件和软件系统将使对其进行的测量与用于检查人类受试者的MRI系统进行的测量相同。