Pre-clinical PET Imaging System

临床前PET成像系统

• 批准号: 7793801
• 负责人: SCOTT E SNYDER
• 金额: $ 50万
• 依托单位: ST. JUDE CHILDREN'S RESEARCH HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-06-17 至 2011-06-16
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7793801
• 关键词: Animals; Biochemical Process; Cancer Center; Child; Collaborations; Collection; Complex; Comprehensive Cancer Center; Custom; Cyclotrons; Data; Discipline of Nuclear Medicine; Disease; Dissection; Dose; Drug Kinetics; Environment; Faculty; Functional disorder; Funding; Grant; Hospitals; Hour; Image; Imaging Techniques; Institution; Investments; Location; Measurement; Medical Imaging; Methods; Modeling; Pediatric Oncology; Pharmaceutical Chemistry; Pharmaceutical Preparations; Positron-Emission Tomography; Pre-Clinical Model; Process; Radiochemistry; Radiopharmaceuticals; Regimen; Regulation; Research; Research Personnel; Resources; Stimulus; System; Technology; Testing; Therapeutic; Time; Titrations; Transgenic Model; Transgenic Organisms; Translational Research; United States National Institutes of Health; Xenograft Model; Xenograft procedure; animal breeding; cellular oncology; cost; design; in vivo; molecular imaging; novel; novel therapeutics; pre-clinical; preclinical study; programs; public health relevance; radiotracer; response; tumor

DESCRIPTION (provided by applicant): With the recent addition of a cyclotron and radiochemistry facility to our Nuclear Medicine Division, St Jude Children's Research Hospital investigators now have access to a wide variety of both known and novel radiotracers for positron emission tomography (PET) imaging. The small animal PET scanner that is the subject of this application is requested to expand the capabilities of our existing Animal Imaging Center (AIC) to take full advantage of this newly acquired access to PET radiotracers. We are currently engaged in several collaborative projects using PET radiotracers for preclinical studies. These studies, while very powerful and quantitative, are limited in that without a small animal PET scanner, they require sacrifice and dissection of the subject animals and yield data at only discrete time points. The real strength of PET lies in the ability to make such quantitative measurements of in vivo biochemical processes in real time. Furthermore, the ability to make repeated measurements in the same animal over hours, days or weeks allows assessment of longitudinal parameters such as therapy response, subject-specific titration of drug doses and regulation of biochemical processes in response to stimuli. Similarly, new therapeutic discovery would benefit from the in vivo pharmacokinetic studies possible in real time with small animal PET using custom designed radiotracers. All of these latter studies are much more complex and expensive, or simply impossible, using dissection methods rather than in vivo imaging. In addition, our institution has a diverse collection of unique preclinical models (both transgenic and xenograft) with which to study disease processes and test new therapeutic regimens in pediatric oncology. All of these models could greatly benefit from the unique capabilities of PET imaging to enhance current research efforts. Dissection studies that assess tumor pathophysiology (as we do now) are challenging in orthotopic xenograft models where exact tumor location is less predictable. Furthermore, non-terminal imaging is the only practical method for studies of transgenic models due to the cost and difficulty of animal breeding. The AIC serves as a core resource to all St Jude investigators and is funded in part by our NCI Comprehensive Cancer Center grant. We have identified 12 faculty investigators who would be the primary users of this core technology, most of whom have funded research efforts on one or multiple NIH grants and are engaged in multi-disciplinary collaborative projects with one or more investigators at St Jude and at other institutions. They represent 6 academic departments and 4 Cancer Center Programs with a variety of expertise in imaging, molecular and cellular oncology, pharmacokinetics, therapeutic design and medicinal chemistry. The addition of a small animal PET scanner will allow us to fully capture this environment of collaboration and the institution's investment in Nuclear Medicine research and will facilitate St Jude's commitment to outstanding translational research. PUBLIC HEALTH RELEVANCE: St Jude Children's Research Hospital is dedicated to the study and treatment of catastrophic disease in children. With the recent addition of a cyclotron and radiochemistry facility to our Nuclear Medicine Division, St Jude Children's Research Hospital investigators now have access to a variety of novel radioactive drugs for a medical imaging procedure called positron emission tomography. The addition of a preclinical PET imaging camera will allow us to take full advantage of both this recent investment in Nuclear Medicine research and the existing variety of preclinical models unique to our institution, thus facilitating St Jude's commitment to outstanding translational research.

描述（由申请人提供）：随着最近在我们的核医学部门添加了回旋和放射化学设施，St Jude儿童研究医院的研究人员现在可以使用各种知名和新颖的放射性示踪剂（PET）成像。要求该应用程序的小型动物PET扫描仪扩大我们现有动物成像中心（AIC）的能力，以充分利用这种新近获得的宠物放射性示例。目前，我们使用PET Radiotracers进行临床前研究，从事几个协作项目。这些研究虽然非常强大且具有定量性，但受到限制，因为如果没有小动物pet扫描仪，它们就需要对主体动物进行牺牲和解剖，并仅在离散时间点产生数据。 PET的真正优势在于能够实时对体内生化过程进行这种定量测量。此外，在数小时，几天或几周内重复测量的能力允许评估纵向参数，例如治疗反应，药物剂量的特定受试者滴定以及对刺激的响应的生化过程调节。同样，使用定制设计的放射性示踪剂，新的治疗发现将受益于实时的体内药代动力学研究。所有这些后者的研究都使用解剖方法而不是体内成像更为复杂和昂贵，或者根本不可能。 此外，我们的机构还采用多种独特的临床前模型（转基因和异种移植）来研究疾病过程并测试小儿肿瘤学中新的治疗方案。所有这些模型都可以从宠物成像的独特功能中受益匪浅，以增强当前的研究工作。在原位异种移植模型中，评估肿瘤病理生理学的解剖研究（正如我们现在所做的那样）在确切的肿瘤位置较低的原位异种移植模型中具有挑战性。此外，由于动物育种的成本和困难，非末端成像是研究转基因模型的唯一实用方法。 AIC是所有St裘德调查人员的核心资源，部分由我们的NCI综合癌症中心赠款资助。我们已经确定了12名教师调查员，他们将成为这项核心技术的主要用户，其中大多数人资助了一项或多项NIH赠款的研究工作，并与St Jude和其他机构的一个或多个研究人员一起从事多学科合作项目。他们代表6个学术部门和4个癌症中心计划，在成像，分子和细胞肿瘤学，药代动力学，治疗设计和药用化学方面具有各种专业知识。添加小型动物PET扫描仪将使我们能够充分捕捉这种协作环境以及该机构对核医学研究的投资，并将促进St Jude对杰出转化研究的承诺。 公共卫生相关性：圣裘德儿童研究医院致力于研究和治疗儿童灾难性疾病。随着最近在我们的核医学部门添加了一种回旋和放射化学设施，St Jude儿童研究医院的调查人员现在可以使用各种新型放射性药物进行医学成像程序，称为Potitron排放 断层扫描。增加临床前宠物成像摄像头将使我们能够充分利用这项在核医学研究中的这项投资和我们机构独有的临床前模型的现有种类，从而促进了圣裘德对杰出翻译研究的承诺。