Salivary Soluble Markers in Head and Neck Cancer

头颈癌中唾液可溶性标记物

基本信息

批准号：
7680965
负责人：
Elizabeth J Franzmann
金额：
$ 12.21万
依托单位：
UNIVERSITY OF MIAMI SCHOOL OF MEDICINE
依托单位国家：
美国
项目类别：
财政年份：
2007
资助国家：
美国
起止时间：
2007-06-04 至 2010-05-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7680965
关键词：
Accounting Alcohols Bathing Biological Assay Biological Markers CD44 gene Case-Control Studies Clinical Collection Community Healthcare Control Groups Data Detection Diagnosis Diagnostic tests Disadvantaged Disease Early Diagnosis Enzyme-Linked Immunosorbent Assay Goals Head and Neck Cancer Head and Neck Squamous Cell Carcinoma Hyaluronic Acid Hyaluronidase Individual Invasive Larynx Malignant Neoplasms Measures Minority Mucous Membrane Newly Diagnosed Oral Outcome Patients Performance Pharyngeal structure Population Process Research Design Research Personnel Risk Risk Factors Saliva Salivary Screening procedure Sensitivity and Specificity Site Specificity Staging Standards of Weights and Measures Survival Rate Testing Time Tobacco United States alcohol exposure base cancer diagnosis design improved low socioeconomic status malignant mouth neoplasm outcome forecast programs tumorigenesis

项目摘要

DESCRIPTION (provided by applicant): Head and neck squamous cell carcinoma (HNSCC) is a devastating disease accounting for 500,000 new cancers cases worldwide each year. Only 50% of patients with HNSCC are cured, largely because the majority of cancers are diagnosed in late stage. This challenge is more pronounced in black patients compared to white patients and economically disadvantaged populations compared to wealthy populations. Better diagnostic tests for HNSCC are needed. CD44, hyaluronic acid (HA) and hyaluronidase (HAase) are related molecules involved in the process of tumorigenesis. They exist in soluble form, are detectable in oral rinses, and are measured by simple and inexpensive ELISA or ELISA-like assays. Our main objective is to evaluate the accuracy of a marker panel comprised of soluble CD44, HA and HAase in distinguishing between patients with invasive HNSCC and controls. To do this we will use a case-control study design and will pursue the following Specific Aims. In Specific Aim 1 we determine whether solCD44, HA and HAase levels in oral rinses distinguish between patients with newly diagnosed, invasive HNSCC and high-risk controls with favorable sensitivity and specificity. In Specific Aim 2 we assess short-term variability of solCD44, HA, and HAase levels in oral rinses from control and HNSCC patients. Our long-term goal is to design and perform a definitive screening trial with the outcomes of early detection and most definitively, survival. This project is relevant to the needs of the health care community because it provides the first step towards our long-term goal, and includes the populations most in need of improved detection, namely minorities and the economically disadvantaged.

描述（由申请人提供）：头颈鳞状细胞癌 (HNSCC) 是一种毁灭性的疾病，每年在全球范围内造成 500,000 例新癌症病例。只有 50% 的 HNSCC 患者能够治愈，很大程度上是因为大多数癌症都是在晚期才被诊断出来的。与白人患者相比，黑人患者面临的这一挑战更为明显；与富裕人群相比，经济弱势群体的这一挑战更为明显。需要更好的 HNSCC 诊断测试。 CD44、透明质酸（HA）和透明质酸酶（HAase）是参与肿瘤发生过程的相关分子。它们以可溶形式存在，可在口腔冲洗液中检测到，并可通过简单且廉价的 ELISA 或类 ELISA 测定进行测量。我们的主要目标是评估由可溶性 CD44、HA 和 HAase 组成的标记物组在区分侵袭性 HNSCC 患者和对照患者方面的准确性。为此，我们将采用病例对照研究设计，并追求以下具体目标。在具体目标 1 中，我们确定口腔冲洗液中的 solCD44、HA 和 HAase 水平是否能够以良好的敏感性和特异性区分新诊断的侵袭性 HNSCC 患者和高风险对照患者。在具体目标 2 中，我们评估了对照和 HNSCC 患者口腔冲洗液中 solCD44、HA 和 HAase 水平的短期变异性。我们的长期目标是设计并进行明确的筛查试验，得出早期检测结果和最明确的生存结果。该项目与医疗保健界的需求相关，因为它为我们的长期目标迈出了第一步，并且包括最需要改进检测的人群，即少数族裔和经济弱势群体。