Acuson Sequoia C512 Echocardiography System

Acuson Sequoia C512 超声心动图系统

• 批准号: 7791820
• 负责人: Sandrine V Pierre
• 金额: $ 10.05万
• 依托单位: UNIVERSITY OF TOLEDO HEALTH SCI CAMPUS
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-08-01 至 2011-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7791820
• 关键词: Advisory Committees; Animal Experimentation; Animals; Applications Grants; Area; Binding; Blood Pressure; Calpain; Cardiac; Cardiac Myocytes; Cardiomyopathies; Cardiovascular Diseases; Cardiovascular system; Cell membrane; Complex; Contract Services; Data; Development; Diabetes Mellitus; Digitalis preparation; Echocardiography; Equipment; Funding; Genetic Determinism; Grant; Health Sciences; Heart; Heart Hypertrophy; Heart failure; Hypertension; Hypertrophy; Image; Insulin Resistance; Laboratories; Left Ventricular Hypertrophy; Mediating; Medical; Metabolic syndrome; Minor; Myocardial Ischemia; Na(+)-K(+)-Exchanging ATPase; Performance; Pharmacology; Phenotype; Physiological; Physiology; Process; Program Research Project Grants; Research; Research Personnel; Resource Sharing; Role; Schedule; Sequoia; Signal Transduction; Solutions; Supervision; System; TRPC3 ion channel; Training; Ultrasonography; Universities; Work; atherogenesis; cost; diabetic cardiomyopathy; fatty acid metabolism; instrument; instrumentation; meetings; public health relevance; receptor; repaired; response; tool

DESCRIPTION (provided by applicant): This is a shared instrumentation proposal to acquire an ACUSON SequoiaTM C512 cardiac ultrasound imaging system, manufactured by Siemens Medical Solutions USA, Inc. Echocardiography is widely accepted as a valuable research tool for studying a broad range of cardiovascular disease processes in small animals, including ischemic heart disease, heart failure, cardiac hypertrophy and remodeling, hypertension and diabetic cardiomyopathy. Although the University of Toledo has nationally recognized NIH-funded investigators working in many of these areas, the university currently does not have adequate access to an ultrasound machine that is capable of providing in-depth cardiac assessment of small research animals. Consequently, investigators have had to seek alternative, invasive approaches to assessing cardiac function and remodeling, leading to higher costs, increased animal use and lower efficiency. By meeting a critical need for small animal echocardiography, the acquisition of the ACUSON Sequoia system will greatly facilitate progress on active NIH-sponsored R01 projects as well as a Program Project Grant (2P01) directed by the major users. In addition, access to this shared equipment will be extended to minor users and new users who have active grant support or are seeking to develop preliminary data for new grant applications. The equipment will be located in the Cardiovascular Phenotyping Core Laboratory of the Department of Physiology and Pharmacology on the University of Toledo's Health Science Campus, and space within the lab will be allocated to facilitate studies for all users. The day-to-day scheduling, training, and technical support for the instrument will be handled under the auspices of the Core Laboratory, with administrative supervision from the PI and an Internal Advisory Committee. Institutional support for the instrument will come in the form of space allocation and a 50% subsidy for the annual service contract. Ongoing projects that will benefit from the Sequoia system include: 1) Studies aimed at exploring mechanisms of digitalis mediated cardiac myocyte hypertrophy; 2) Studies of the molecular interactions that constitute the formation of the Na/K-ATPase/Src receptor complex, and to evaluate the functionality and physiologic response of this newly discovered receptor in digitalis- activated signal transduction in the heart; 3) Studies to identify genetic determinants of blood pressure and their effects on cardiac function and remodeling; and 4) Studies aimed at identifying the mechanisms by which insulin resistance leads to metabolic syndrome and its associated cardiovascular effects. Several new projects focused on cardiac fatty acid metabolism, uremic cardiomyopathy, the role of calpains in the repair of the damaged plasma membranes of damaged cardiomyoctes, and the role of TRPC3 channels in atherogenesis and the development of left ventricular hypertrophy will also benefit from the availability of the requested imaging system. By accelerating progress on these diverse projects, this shared instrumentation will have a major positive impact on health-related research at the University of Toledo. PUBLIC HEALTH RELEVANCE: We are requesting funds to acquire an ACUSON SequoiaTM C512 cardiac ultrasound system, which is a well established instrument with an excellent performance record and widespread acceptance of echocardiographic data generated from large and small research animals alike. This instrument is not currently available at this university. It will be operated as a shared resource to accelerate the cardiovascular-related research of numerous investigators including three major users who are engaged in NIH-sponsored projects focused on cardiac hypertrophy, hypertension and diabetes.

描述（由申请人提供）：这是一项共享仪器提案，旨在购买由西门子医疗解决方案美国公司制造的 ACUSON SequoiaTM C512 心脏超声成像系统。超声心动图被广泛认为是研究各种心血管疾病的有价值的研究工具小动物的疾病过程，包括缺血性心脏病、心力衰竭、心脏肥大和重塑、高血压和糖尿病心肌病。尽管托莱多大学拥有国家认可的美国国立卫生研究院 (NIH) 资助的研究人员在许多这些领域开展工作，但该大学目前没有足够的机会使用能够对小型研究动物进行深入心脏评估的超声波机器。因此，研究人员不得不寻找替代的侵入性方法来评估心脏功能和重塑，从而导致成本更高、动物使用增加和效率降低。通过满足小动物超声心动图的关键需求，收购 ACUSON Sequoia 系统将极大地促进 NIH 资助的 R01 项目以及主要用户指导的计划项目拨款 (2P01) 的进展。此外，对这种共享设备的访问将扩展到未成年用户和获得积极赠款支持或正在寻求为新赠款申请开发初步数据的新用户。该设备将位于托莱多大学健康科学校区生理学和药理学系的心血管表型核心实验室，实验室内的空间将被分配以方便所有用户的研究。该仪器的日常调度、培训和技术支持将在核心实验室的主持下处理，并接受 PI 和内部咨询委员会的行政监督。对该仪器的机构支持将以空间分配和年度服务合同 50% 补贴的形式提供。将从 Sequoia 系统中受益的正在进行的项目包括： 1）旨在探索洋地黄介导的心肌细胞肥大机制的研究； 2）研究构成Na/K-ATPase/Src受体复合物形成的分子相互作用，并评估这种新发现的受体在心脏中洋地黄激活信号转导中的功能和生理反应； 3) 研究确定血压的遗传决定因素及其对心脏功能和重构的影响； 4) 旨在确定胰岛素抵抗导致代谢综合征及其相关心血管影响的机制的研究。几个专注于心脏脂肪酸代谢、尿毒症心肌病、钙蛋白酶在受损心肌细胞质膜修复中的作用以及TRPC3通道在动脉粥样硬化形成和左心室肥厚发展中的作用的几个新项目也将受益于这些项目的可用性所要求的成像系统。通过加速这些不同项目的进展，这种共享仪器将对托莱多大学的健康相关研究产生重大积极影响。 公共健康相关性：我们正在申请资金购买 ACUSON SequoiaTM C512 心脏超声系统，这是一款完善的仪器，具有出色的性能记录，并且广泛接受大型和小型研究动物生成的超声心动图数据。该大学目前不提供该仪器。它将作为共享资源运行，以加速众多研究人员的心血管相关研究，其中包括参与 NIH 资助的心脏肥大、高血压和糖尿病项目的三位主要用户。