Acuson Sequoia C512 Echocardiography System

Acuson Sequoia C512 超声心动图系统

• 批准号: 7791820
• 负责人: Sandrine V Pierre
• 金额: $ 10.05万
• 依托单位: UNIVERSITY OF TOLEDO HEALTH SCI CAMPUS
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-08-01 至 2011-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7791820
• 关键词: Advisory Committees; Animal Experimentation; Animals; Applications Grants; Area; Binding; Blood Pressure; Calpain; Cardiac; Cardiac Myocytes; Cardiomyopathies; Cardiovascular Diseases; Cardiovascular system; Cell membrane; Complex; Contract Services; Data; Development; Diabetes Mellitus; Digitalis preparation; Echocardiography; Equipment; Funding; Genetic Determinism; Grant; Health Sciences; Heart; Heart Hypertrophy; Heart failure; Hypertension; Hypertrophy; Image; Insulin Resistance; Laboratories; Left Ventricular Hypertrophy; Mediating; Medical; Metabolic syndrome; Minor; Myocardial Ischemia; Na(+)-K(+)-Exchanging ATPase; Performance; Pharmacology; Phenotype; Physiological; Physiology; Process; Program Research Project Grants; Research; Research Personnel; Resource Sharing; Role; Schedule; Sequoia; Signal Transduction; Solutions; Supervision; System; TRPC3 ion channel; Training; Ultrasonography; Universities; Work; atherogenesis; cost; diabetic cardiomyopathy; fatty acid metabolism; instrument; instrumentation; meetings; public health relevance; receptor; repaired; response; tool

DESCRIPTION (provided by applicant): This is a shared instrumentation proposal to acquire an ACUSON SequoiaTM C512 cardiac ultrasound imaging system, manufactured by Siemens Medical Solutions USA, Inc. Echocardiography is widely accepted as a valuable research tool for studying a broad range of cardiovascular disease processes in small animals, including ischemic heart disease, heart failure, cardiac hypertrophy and remodeling, hypertension and diabetic cardiomyopathy. Although the University of Toledo has nationally recognized NIH-funded investigators working in many of these areas, the university currently does not have adequate access to an ultrasound machine that is capable of providing in-depth cardiac assessment of small research animals. Consequently, investigators have had to seek alternative, invasive approaches to assessing cardiac function and remodeling, leading to higher costs, increased animal use and lower efficiency. By meeting a critical need for small animal echocardiography, the acquisition of the ACUSON Sequoia system will greatly facilitate progress on active NIH-sponsored R01 projects as well as a Program Project Grant (2P01) directed by the major users. In addition, access to this shared equipment will be extended to minor users and new users who have active grant support or are seeking to develop preliminary data for new grant applications. The equipment will be located in the Cardiovascular Phenotyping Core Laboratory of the Department of Physiology and Pharmacology on the University of Toledo's Health Science Campus, and space within the lab will be allocated to facilitate studies for all users. The day-to-day scheduling, training, and technical support for the instrument will be handled under the auspices of the Core Laboratory, with administrative supervision from the PI and an Internal Advisory Committee. Institutional support for the instrument will come in the form of space allocation and a 50% subsidy for the annual service contract. Ongoing projects that will benefit from the Sequoia system include: 1) Studies aimed at exploring mechanisms of digitalis mediated cardiac myocyte hypertrophy; 2) Studies of the molecular interactions that constitute the formation of the Na/K-ATPase/Src receptor complex, and to evaluate the functionality and physiologic response of this newly discovered receptor in digitalis- activated signal transduction in the heart; 3) Studies to identify genetic determinants of blood pressure and their effects on cardiac function and remodeling; and 4) Studies aimed at identifying the mechanisms by which insulin resistance leads to metabolic syndrome and its associated cardiovascular effects. Several new projects focused on cardiac fatty acid metabolism, uremic cardiomyopathy, the role of calpains in the repair of the damaged plasma membranes of damaged cardiomyoctes, and the role of TRPC3 channels in atherogenesis and the development of left ventricular hypertrophy will also benefit from the availability of the requested imaging system. By accelerating progress on these diverse projects, this shared instrumentation will have a major positive impact on health-related research at the University of Toledo. PUBLIC HEALTH RELEVANCE: We are requesting funds to acquire an ACUSON SequoiaTM C512 cardiac ultrasound system, which is a well established instrument with an excellent performance record and widespread acceptance of echocardiographic data generated from large and small research animals alike. This instrument is not currently available at this university. It will be operated as a shared resource to accelerate the cardiovascular-related research of numerous investigators including three major users who are engaged in NIH-sponsored projects focused on cardiac hypertrophy, hypertension and diabetes.

描述（由申请人提供）：这是一项共同的仪器建议，用于获取由西门子医疗解决方案美国制造的Acuson sequoiatm C512心脏超声成像系统。心肌病。尽管托莱多大学在许多此类领域工作的NIH资助的研究人员已经认可了全国性的NIH资助的调查人员，但该大学目前无法充分访问能够提供小型研究动物心脏评估的超声机器。因此，研究人员不得不寻求替代的，侵入性的方法来评估心脏功能和重塑，从而导致更高的成本，增加动物使用和降低效率。通过满足对小动物超声心动图的关键需求，对Acuson红杉系统的获取将极大地促进主动NIH赞助的R01项目以及主要用户指导的计划项目赠款（2P01）的进步。此外，对该共享设备的访问将扩展到具有积极赠款支持或正在寻求为新赠款应用程序开发初步数据的未次要用户和新用户。该设备将位于托莱多大学健康科学校园生理学和药理学系的心血管表型核心实验室中，实验室内的空间将被分配以促进所有用户的研究。在PI和内部咨询委员会的行政监督下，将在核心实验室的主持下处理对该工具的日常安排，培训和技术支持。对该工具的机构支持将以空间分配的形式出现，并为年度服务合同提供50％的补贴。将从红杉系统中受益的正在进行的项目包括：1）旨在探索digitalis介导的心肌肥大机制的研究； 2）研究构成Na/k-ATPase/SRC受体复合物的形成的分子相互作用，并评估该新发现的受数字化受体在心脏中被数字激活的信号转导的受体的功能和生理反应； 3）研究以确定血压及其对心脏功能和重塑的影响的研究； 4）旨在确定胰岛素抵抗会导致代谢综合征及其相关心血管效应的机制的研究。几个新项目的重点是心脏脂肪酸代谢，尿毒症心肌病，CALPAIN在修复受损心肌受损的受损质膜中的作用以及TRPC3通道在动脉粥样硬化中的作用以及左心室肥大的发展以及左心室肥大的发展也将受益于请求的知识系统的可用性。通过加速这些不同项目的进展，这种共同的工具将对托莱多大学的健康相关研究产生重大积极影响。 公共卫生相关性：我们要求资金购买Acuson红杉C512心脏超声系统，该系统是一种良好的仪器，具有出色的性能记录，并广泛接受了来自大型和小型研究动物产生的超声心动图数据。该工具目前尚未在该大学提供。它将作为共享资源运行，以加快与心血管相关的研究的加速研究，其中包括三名主要使用NIH赞助项目的主要用户，这些项目专注于心脏肥大，高血压和糖尿病。