Microspect Scanner for Small Animal Radionuclide Imaging

用于小动物放射性核素成像的显微扫描仪

• 批准号: 7795376
• 负责人: Ming Zhao
• 金额: $ 50万
• 依托单位: MEDICAL COLLEGE OF WISCONSIN
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-08-15 至 2011-08-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7795376
• 关键词: Animal Experimentation; Animals; Arts; Cardiovascular system; Clinical; Communities; Core Facility; Event; Funding; Funding Applicant; Image; Interdisciplinary Study; Investigation; Kidney; Lung; Malignant Neoplasms; Measurement; Minor; Molecular; Organism; Play; Productivity; Radionuclide Imaging; Regenerative Medicine; Research; Research Activity; Research Personnel; Research Project Grants; Research Support; Resolution; Role; Techniques; Translational Research; Wisconsin; detector; imaging modality; instrument; medical schools; novel; programs; public health relevance; single photon emission computed tomography; tool

DESCRIPTION (provided by applicant): Funds are requested for the purchase of a dual-detector microSPECT scanner (NanoSPECT/CT scanner, BioScan, Inc.) dedicated to small animal research. Radionuclide imaging constitutes a robust tool for the investigation of molecular events in the living system. A high- resolution SPECT scanner of this kind is not available at the Medical College of Wisconsin (MCW), or in the state of Wisconsin. The instrument will become an integral part of the existing multi- modality imaging core facility at MCW and benefit a broad range of research projects by providing noninvasive, three-dimensional, quantitative and longitudinal measurements. The proposed scanner will play a major role in the basic and translational research using novel and established clinical imaging agents and techniques. Eight NIH-funded Program Projects (PPGs) and 20 NIH-funded investigators from a highly interdisciplinary research network will form five major user groups, encompassing cancer, cardiovascular, pulmonary, regenerative medicine, and renal studies. The instrument will also be shared by minor users in the regional research community. A state-of-the-art small animal SPECT/CT scanner will immediately and significantly advance the productivity of local research activities. PUBLIC HEALTH RELEVANCE: Funds are requested to enable the purchase of a dual-detector microSPECT scanner dedicated to small animal imaging research. The proposed scanner will play a major role in the basic and translational research, supporting five major user groups (8 NIH-funded PPGs and 20 investigators) encompassing cancer, cardiovascular, pulmonary, regenerative medicine, and renal studies. The instrument will also be shared by minor users in the regional research community. A state-of-the-art small animal SPECT scanner will immediately and significantly advance the productivity of local research activities from a highly interdisciplinary network.

描述（由申请人提供）：要求购买双探测器微型扫描仪（Nanospect/CT扫描仪，Bioscan，Inc。）的资金。放射性核素成像构成了研究生命系统中分子事件的强大工具。威斯康星州医学院（MCW）或威斯康星州无法获得此类高分辨率SPECT扫描仪。该仪器将成为MCW现有多种模态成像核心设施的组成部分，并通过提供非侵入性，三维，定量和纵向测量来使广泛的研究项目受益。拟议的扫描仪将使用新颖和已建立的临床成像剂和技术在基本和翻译研究中发挥重要作用。来自NIH资助的计划项目（PPG）和来自高度跨学科研究网络的20名NIH资助的研究人员将组成五个主要用户组，包括癌症，心血管，肺部，再生医学和肾脏研究。该仪器还将由区域研究社区中的次要用户共享。最先进的小动物SPECT/CT扫描仪将立即并显着提高当地研究活动的生产率。 公共卫生相关性：要求资金以购买专门用于小型动物成像研究的双探测器微镜扫描仪。拟议的扫描仪将在基本和转化研究中发挥重要作用，支持五个主要用户组（8个由NIH资助的PPG和20名研究者），其中包括癌症，心血管，肺部，再生医学和肾脏研究。该仪器还将由区域研究社区中的次要用户共享。最先进的小动物SPECT扫描仪将立即从高度跨学科的网络中显着提高本地研究活动的生产率。

项目成果

Evaluation of chemotherapy response in VX2 rabbit lung cancer with 18F-labeled C2A domain of synaptotagmin I.

使用突触结合蛋白 I 的 18F 标记的 C2A 结构域评估 VX2 兔肺癌的化疗反应。

• DOI: 10.2967/jnumed.110.081588
• 发表时间: 2011-04
• 期刊: Journal of nuclear medicine : official publication, Society of Nuclear Medicine
• 作者: Wang F;Fang W;Zhang MR;Zhao M;Liu B;Wang Z;Hua Z;Yang M;Kumata K;Hatori A;Yamasaki T;Yanamoto K;Suzuki K
• 通讯作者: Suzuki K

Understanding the in vivo uptake kinetics of a phosphatidylethanolamine-binding agent (99m)Tc-Duramycin.

• DOI: 10.1016/j.nucmedbio.2012.02.004
• 发表时间: 2012-08
• 期刊: Nuclear medicine and biology
• 影响因子: 3.1
• 作者: Audi S;Li Z;Capacete J;Liu Y;Fang W;Shu LG;Zhao M
• 通讯作者: Zhao M

Lantibiotics as probes for phosphatidylethanolamine.

• DOI: 10.1007/s00726-009-0386-9
• 发表时间: 2011-11
• 期刊: AMINO ACIDS
• 影响因子: 3.5
• 作者: Zhao, Ming

A single-step kit formulation for the (99m)Tc-labeling of HYNIC-Duramycin.

• DOI: 10.1016/j.nucmedbio.2012.03.006
• 发表时间: 2012-10
• 期刊: Nuclear medicine and biology
• 影响因子: 3.1
• 作者: Zhao M;Li Z
• 通讯作者: Li Z

In vivo detection of hyperoxia-induced pulmonary endothelial cell death using (99m)Tc-duramycin.

• DOI: 10.1016/j.nucmedbio.2014.08.010
• 发表时间: 2015-01
• 期刊: Nuclear medicine and biology
• 影响因子: 3.1
• 作者: Audi SH;Jacobs ER;Zhao M;Roerig DL;Haworth ST;Clough AV
• 通讯作者: Clough AV