Human developmental toxicity of metal mixture exposure from e-waste recycling

电子废物回收中接触金属混合物对人体发育的毒性

• 批准号: 8046947
• 负责人: Aimin Chen
• 金额: $ 172.29万
• 依托单位: UNIVERSITY OF CINCINNATI
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-27 至 2013-09-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8046947
• 关键词: Acids; Address; Adverse effects; Affect; Age-Months; Air; Aluminum; Area; Biological; Birth Weight; Birth length; Blood; Burn injury; Cadmium; Child; China; Chinese People; Chromium; Collaborations; Complex; Copper; Data; Developed Countries; Developing Countries; Development; Dust; Educational workshop; Electronics; Enrollment; Environmental Health; Exposure to; Fetal Growth; Fetus; Funding; Future; Ghana; Goals; Gold; Hair; Head circumference; Health; Health Policy; Heating; Heavy Metals; Human; India; Infant; Infant Development; Intervention; Investigation; Iron; Knowledge; Lead; Length; Manganese; Medical; Mercury; Metals; Mission; Morbidity - disease rate; Nickel; Nigeria; Outcome; Pakistan; Participant; Pathway interactions; Policy Making; Positioning Attribute; Postpartum Period; Pregnancy; Pregnancy Outcome; Pregnant Women; Premature Birth; Prevention; Prevention strategy; Process; Production; Public Health; Recruitment Activity; Recycling; Research; Research Personnel; Site; Small for Gestational Age Infant; Soil; Solid; Solutions; Stream; Thyroid Function Tests; Thyroid Hormones; Tin; Toxic Environmental Substances; Toxic effect; Toxicant exposure; Umbilical Cord Blood; United States National Institutes of Health; Universities; Urine; Vietnam; Vulnerable Populations; Zinc; base; chromium hexavalent ion; design; fetal; follow-up; forging; global environment; global health; human data; human study; innovation; medical schools; metal poisoning; mortality; neurobehavioral; neurodevelopment; novel; perinatal health; pollutant; prospective; reproductive; response; stillbirth; toxicant; wasting

DESCRIPTION (provided by applicant): This application addresses one of the five thematic areas in the RFA-OD-10-005: Focusing on Global Health. Electronic waste (e-waste) has become a global environmental health problem because of its huge amount of production worldwide--approximately 20-50 million tons per year. E-waste contains high levels of several metals (lead [Pb], mercury [Hg], cadmium [Cd], chromium [Cr], manganese [Mn], etc.), but inappropriate and unregulated recycling exposes the workers and residents in many towns and villages in developing countries. Public health investigations into the exposure levels and potential toxicity in vulnerable population are urgently needed to address this critical environmental health problem. This research is closely related to NIH mission on global health to reduce preventable morbidity and mortality in developing countries. Developing fetuses and young children are especially susceptible to environmental toxicants. The metal mixture in e-waste is unique in its composition and concentrations, but the toxicity of this complex exposure is virtually unknown in developing fetuses and young children. The long-term goal is to investigate developmental effects of e-waste toxicant mixtures and provide human study evidence to inform future regulatory actions and public health prevention. The application will address this global health problem by recruiting 600 pregnant women (300 from an e-waste recycling site and 300 from a control site in China) and following up to 9 months postpartum. The applicants will accomplish three Specific Aims: 1) Characterize the e-waste metal mixture exposure in pregnant women and their fetuses; 2) Examine adverse pregnancy outcomes associated with e-waste metal mixture exposure; and 3) Investigate neurodevelopmental toxicity and thyroid hormone disruption of e-waste metal mixture exposure. The applicants will assess the environmental (air, dust, soil) and biological (maternal blood, urine, hair, cord blood) exposure markers of e-waste metal mixtures (Pb, Hg, Cd, Cr, Mn). Pregnancy outcomes (stillbirth, gestational length, preterm birth, birth weight, small for gestational age [SGA], birth length, head circumference, anogenital distance [AGD]), thyroid hormones (TSH, T4, T3), and infant neurodevelopment (Bayley Scales of Infant Development-2 [BSID-2]) will be examined. This study will provide novel data about metal toxicants in e-waste and developmental outcomes in humans, increase scientific knowledge about rarely studied mixture exposure, and inform environmental health policy making to reduce e- waste toxicant exposure in developing countries. PUBLIC HEALTH RELEVANCE: The proposed study will address a critical issue of global environmental health--enormous e-waste production but with prevailing primitive recycling in developing countries. This study will address the developmental effects of metal mixtures from primitive e-waste recycling activities. It will inform environmental health policy making to manage the e-waste and protect human health.

描述（由申请人提供）：此申请介绍了RFA-OD-10-005中的五个主题领域之一：专注于全球健康。由于全球生产大量生产，电子废物（电子废物）已成为全球环境健康问题，每年约为20-50亿吨。电子废物含有高水平的几种金属（铅[PB]，汞[HG]，镉[CD]，铬[CR]，锰[Mn]等），但不适当且不受管制的回收使发展中国家许多城镇的工人和居民暴露出。迫切需要对脆弱人群的暴露水平和潜在毒性进行公共卫生调查，以解决这一关键的环境健康问题。这项研究与NIH全球健康的使命密切相关，以减少发展中国家的可预防发病率和死亡率。发展胎儿和幼儿特别容易受到环境有毒物质的影响。电子废物中的金属混合物在其组成和浓度方面是独一无二的，但是这种复杂暴露的毒性在发育中的胎儿和幼儿中实际上是未知的。长期目标是研究电子废物有毒物质混合物的发育效果，并提供人类研究证据，以告知未来的监管行动和预防公共卫生。该申请将通过招募600名孕妇（来自电子垃圾回收现场的300名，来自中国的控制地点的300名）并在产后9个月后跟随9个月，通过招募600名孕妇（300名孕妇，300名来自300名孕妇（300名）来解决这个全球健康问题。申请人将完成三个特定目标：1）表征孕妇及其胎儿的电子废物金属混合物； 2）检查与电子垃圾金属混合物暴露有关的不良妊娠结局； 3）研究神经发育的毒性和甲状腺激素破坏了电子垃圾金属混合物的暴露。申请人将评估电子垃圾金属混合物（PB，HG，CD，CR，CR，MN）的环境（空气，灰尘，土壤）和生物学（母血，尿液，头发，脐带血）。妊娠结局（胎儿，胎儿长度，早产，出生体重，小针对胎龄[SGA]，出生时间，头围，肛门生殖器距离[AGD]），甲状腺激素（TSH，TSH，T4，T3）和婴儿神经脱发（婴儿神经脱发（Bayleant Neurodeverment）（Bayley Neurodeverment（bayley scale scape of BASELEY量表[BSID-2] [BSID-2]）将被检查。这项研究将提供有关人类电子垃圾和发育结果中金属有毒物质的新数据，增加有关很少研究的混合物暴露的科学知识，并为制定环境健康政策提供依据，以减少发展中国家的e-废物毒性暴露。 公共卫生相关性：拟议的研究将解决全球环境健康的关键问题 - 巨大的电子废物生产，但在发展中国家盛行了原始回收利用。这项研究将解决原始电子废物回收活动中金属混合物的发育效果。它将为环境健康政策制定提供信息，以管理电子废物并保护人类健康。