Minority Health-GRID Network: A Genomics Resource for Health Disparity Research

少数民族健康网格网络：健康差异研究的基因组学资源

• 批准号: 8048812
• 负责人: ROBERT Lowell DAVIS
• 金额: $ 1332万
• 依托单位: MOREHOUSE SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-30 至 2013-09-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8048812
• 关键词: Abbreviations; Academic Medical Centers; Address; Admixture; Affect; African American; Architecture; Area; Beds; Behavioral; Behavioral Genetics; Bioethics; Bioinformatics; Caring; Cataloging; Catalogs; Characteristics; Chronic Kidney Failure; Clinic; Clinical; Clinical Data; Clinical Research; Clinical assessments; Collection; Communities; DNA; Data; Data Element; Data Set; Databases; Diabetes Mellitus; Diet; Disease; Electronic Health Record; Elements; Ensure; Environmental Risk Factor; Essential Hypertension; Etiology; Foundations; Frequencies; Genetic; Genetic Determinism; Genetic Markers; Genome; Genomics; Genotype; Health; Health Status; Hypertension; Institutes; Institution; Internet; Kidney Diseases; Kidney Failure; Knowledge; Learning; Link; Malignant neoplasm of prostate; Medical; Medicine; Minority; Minority Groups; Modeling; Myocardial Infarction; Obesity; Outcome; Outcomes Research; Patients; Phenotype; Physical activity; Plague; Population; Population Surveillance; Positioning Attribute; Public Health; Race; Recording of previous events; Research; Research Infrastructure; Resolution; Resources; Science; Scientist; Severities; Southeastern United States; Stroke; Structure; System; Technology; Testing; Translational Research; Translations; Trust; Underrepresented Minority; United States National Institutes of Health; Variant; abstracting; base; burden of illness; cohort; comparative effectiveness; computerized; data modeling; defined contribution; design; disease registry; early onset; effectiveness research; exome; genome-wide; health disparity; health literacy; improved; innovation; insight; medical schools; medically underserved; minority health; novel; premature; programs; public health relevance; racial and ethnic; racial/ethnic difference; repository; safety net; social; tool; virtual

DESCRIPTION (provided by applicant): The persistence of health disparities in medically underserved minority communities remains one of the most vexing public health problems facing our nation; the etiology of racial/ethnic differences in health involves dynamic interactions between genetic, behavioral and social-environmental determinants. Yet the field lacks robust, longitudinal datasets that integrate these multi-dimensional data elements with clinical assessments in minority patient cohorts. The Minority Health Genomics and Translational Research BIo-Repository Database (MH-GRID) Network infrastructure will facilitate the ascertainment of biospecimens, the collection of multi- dimensional data elements and the tracking of patient outcomes in an electronic health records (EHRs)-linked data warehouse within a consortium of minority clinics. This initiative will expand the diversity of bio-ancestral groups in national genomic medicine cohorts, provide a platform for 'virtual' disease registries catalyze comparative effectiveness research in high-health disparity settings and accelerate the translation of 'personalized medicine' into minority communities. This project will fulfill the objectives of the NIH Director's priority areas (RFA-OD-10-005) and the ARRA by pursuing the following specific aims: Aim I: To establish an organizational framework for the Minority Health-GRID Network as a consortium of academic medical centers and minority-serving 'safety-net' medical care facilities. Aim II: To establish an electronic health record (EHR)-linked bioinformatics/bio-repository infrastructure that facilitates in-depth genotyping, phenotypic characterization and longitudinal surveillance of minority patients. Aim III: To demonstrate the unique utility of the MH-GRID resource with a 'use-case' project that defines the genetic, personal and social-environmental determinants of severe hypertension (HTN) in African-Americans. The fulfillment of these specific aims will enable the MH-GRID to establish the largest genomic medicine database devoted to minority patients. A major objective of the MH-GRID is to utilize high-throughput sequencing technology to create a genome-wide catalogue of the 'Exome' in 2400 African-Americans (AA). Overall, this project provides a 'grand opportunity' to establish a novel national research resource that will advance genomic science while addressing a variety of health disparity conditions that currently plague under- served minority communities. PUBLIC HEALTH RELEVANCE: High blood pressure is a very common problem that is a major cause of heart attacks, strokes and kidney failure. It affects African-Americans much more commonly than other racial groups. There are many diseases like high blood pressure that are more common in certain racial/ethnic and there is a need to improve the use of computerized systems in clinics that care for a high proportion of minority patients so that their health status can be improved. In addition, there is much that we have to learn about genetic differences between different minority groups that may contribute to these differences in health. The proposed project will be a major innovation to fill this knowledge gap in the areas of genetics and health disparities.

描述（由申请人提供）：在医学上服务不足的少数民族社区中，健康差异的持续性仍然是我们国家面临的最烦人的公共卫生问题之一；种族/种族差异在健康方面的病因涉及遗传，行为和社会环境决定因素之间的动态相互作用。然而，该领域缺乏可靠的纵向数据集，这些数据集将这些多维数据元素与少数族裔患者同伙的临床评估相结合。少数族裔健康基因组学和转化研究生物re依re-repository数据库（MH-GRID）网络基础架构将有助于确定生物含量，收集多维数据元素的收集以及在电子健康记录（EHRS）中链接数据Warehouse中少数次临时诊所内的电子健康记录（EHRS）中的患者成果的跟踪。该倡议将扩大国家基因组医学队列中生物 - 著名群体的多样性，为“虚拟”疾病注册机构提供了一个平台，可以促进高健康差异环境中的比较有效性研究，并加速“个性化医学”的翻译为少数族裔社区。该项目将通过追求以下特定目标来实现NIH主管优先领域（RFA-OD-10-005）和ARRA的目标：目标I：为少数族裔健康网络建立一个组织框架，作为学术医疗中心和少数民族服务的“安全网络”医疗保健设施。 AIM II：建立电子健康记录（EHR）连接的生物信息学/生物纠正基础设施，以促进少数族裔患者的深入基因分型，表型表征和纵向监视。 AIM III：通过“用例”项目来证明MH-Grid资源的独特效用，该项目定义了非裔美国人严重高血压（HTN）的遗传，个人和社会环境决定因素。 这些特定目标的实现将使MH-Grid能够建立专门针对少数族裔患者的最大基因组医学数据库。 MH-Grid的一个主要目的是利用高通量测序技术来创建2400名非裔美国人（AA）中“外来”的全基因组目录。总体而言，该项目提供了一个“宏伟的机会”来建立一种新颖的国家研究资源，该研究将推进基因组科学，同时解决目前困扰少数民族社区的各种健康差异状况。 公共卫生相关性：高血压是一个非常普遍的问题，是心脏病发作，中风和肾衰竭的主要原因。它比其他种族群体更普遍地影响非裔美国人。在某些种族/种族中，有许多疾病等疾病在某些种族/种族中更常见，并且有必要改善计算机化系统在诊所中的使用，以照顾大量的少数族裔患者，以便可以改善其健康状况。此外，我们必须了解不同少数群体之间的遗传差异，这可能会导致健康差异。拟议的项目将是填补遗传学和健康差异领域的知识差距的主要创新。

项目成果

Study designs and methods post genome-wide association studies.

• DOI: 10.1007/s00439-012-1209-8
• 发表时间: 2012-10
• 期刊: HUMAN GENETICS
• 影响因子: 5.3
• 作者: Ziegler, Andreas;Sun, Yan V.
• 通讯作者: Sun, Yan V.

Perceived neighborhood problems are associated with shorter telomere length in African American women.

• DOI: 10.1016/j.psyneuen.2016.03.018
• 发表时间: 2016-07
• 期刊: PSYCHONEUROENDOCRINOLOGY
• 影响因子: 3.7
• 作者: Gebreab, Samson Y.;Riestra, Pia;Gaye, Amadou;Khan, Rumana J.;Xu, Ruihua;Davis, Adam R.;Quarells, Rakale C.;Davis, Sharon K.;Gibbons, Gary H.
• 通讯作者: Gibbons, Gary H.

Association of Exome Sequences With Cardiovascular Traits Among Blacks in the Jackson Heart Study.

• DOI: 10.1161/circgenetics.116.001410
• 发表时间: 2016-08
• 期刊: Circulation. Cardiovascular genetics
• 作者: Peloso GM;Lange LA;Varga TV;Nickerson DA;Smith JD;Griswold ME;Musani S;Polfus LM;Mei H;Gabriel S;Quarells RC;Altshuler D;Boerwinkle E;Daly MJ;Neale B;Correa A;Reiner AP;Wilson JG;Kathiresan S
• 通讯作者: Kathiresan S

Power analysis and sample size estimation for sequence-based association studies.

基于序列的关联研究的功效分析和样本量估计。

• DOI: 10.1093/bioinformatics/btu296
• 发表时间: 2014
• 期刊: Bioinformatics (Oxford, England)
• 作者: Wang,GaoT;Li,Biao;Santos-Cortez,RegiePLyn;Peng,Bo;Leal,SuzanneM
• 通讯作者: Leal,SuzanneM

Analysis of exome sequencing data sets reveals structural variation in the coding region of ABO in individuals of African ancestry.

外显子组测序数据集分析揭示了非洲血统个体 ABO 编码区的结构变异。

• DOI: 10.1111/trf.13797
• 发表时间: 2016
• 期刊: Transfusion
• 影响因子: 2.9
• 作者: Fox,Keolu;Johnsen,JillM;Coe,BradleyP;Frazar,ChrisD;Reiner,AlexanderP;NHLBIExomeSequencingProject,MinorityHealth-GRIDNetwork;Eichler,EvanE;Nickerson,DeborahA
• 通讯作者: Nickerson,DeborahA