Washington University Nutrition Obesity Research Center

华盛顿大学营养肥胖研究中心

基本信息

批准号：
10160292
负责人：
Samuel Klein
金额：
$ 15万
依托单位：
WASHINGTON UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-06-01 至 2021-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10160292
关键词：
Abbreviations Academic Medical Centers Address Adipocytes Adipose tissue Aging Allied Health Personnel Animal Husbandry Animal Model Applied Research Area Award Basic Science Biochemical Biomedical Research Blood specimen Body Composition Body Weight decreased Breeding Cancer Center Cardiovascular system Cell Line Cell physiology Child Health Clinical Clinical Investigator Clinical Nutrition Clinical Research Clinical Sciences Clinical and Translational Science Awards Collaborations Communication Community Health Community Health Education Complex Data Development Diabetes Mellitus Diet Digestive System Disorders Direct Costs Discipline Disease Echocardiography Endothelium Environment Exercise Faculty Feeding behaviors Food Fostering Functional disorder Funding Gene Expression Genome Genotype Goals Grant Growth and Development function Health Health Personnel Health Promotion Health behavior High Prevalence Home environment Hormones Hospitals House Staffs Human Infrastructure Institutes Intention Interdisciplinary Study Intervention Studies Intestines Intravenous Kinetics Knowledge Laboratories Lead Life Style Magnetic Resonance Imaging Measurement Mentors Metabolic Mitochondria Molecular Molecular Analysis Molecular Biology Morphology Mus Muscle Muscle Cells Nutritional Obesity Patient Care Pediatric Hospitals Performance Physical Performance Physicians Physiology Policy Research Positioning Attribute Prevention Research Public Health Quality of life Research Research Methodology Research Personnel Research Technics Research Training Resource Sharing Sampling Science Services Structure Students Talents Taste Perception Taste preferences Testing Therapeutic Therapeutic Uses Tissue Sample Tissues Tracer Training Training and Education Translational Research Translations Universities Washington adipocyte biology base career development carotid intima-media thickness clinical application clinical center clinical imaging clinical investigation clinical practice community intervention cost effective design diabetic cardiomyopathy economic impact education research exercise intervention follower of religion Jewish gut microbiome improved innovation interdisciplinary approach interest lifestyle intervention mathematical model medical schools metabolic abnormality assessment metabolic phenotype metropolitan mouse model next generation nutrient metabolism nutrition obesity prevention outreach performance tests programs protein expression recruit spectroscopic imaging stable isotope

项目摘要

PROJECT SUMMARY/ABSTRACT – Overview: This application seeks continued funding for the Washington University School of Medicine (WUSM) Nutrition Obesity Research Center (NORC). Since our NORC was first funded in 1999, it has served as a nidus for the growth and development of nutrition and obesity research at WUSM. The infrastructure provided by the NORC has created an environment that supports and stimulates cost-effective and high-quality research, collaborations between investigators, career development and training, and clinical activities in nutrition and obesity. Our NORC has a talented and diverse research base consisting of 109 investigators from 19 departments. These investigators have 179 nutrition/obesity-related grants, generating $42 million/year in direct costs. It is our intention to continue to grow nutrition and obesity-related activities, and to continue to bring state-of-the-art basic and clinical research methods to NORC investigators. The overall research focus of the WUSM NORC has been: 1) Obesity: Pathophysiology, Complications and Therapeutics; 2) Nutrient Metabolism in Health and Disease; and 3) Growth, Development, and Aging. Newly emerging areas of major interest include: 4) Gut Microbiome and 5) Community Health. We propose an Administrative Core and 4 Biomedical Research Cores. The Clinical Science Research Core will provide assistance with: i) subject recruitment, design and performance of complex metabolic studies, ii) body composition assessments, iii) mixing of intravenous tracers and hormone solutions, iv) acquisition of tissue (adipose, muscle, intestine) samples, v) exercise (endurance and strength) and physical performance testing, vi) lifestyle (diet manipulation, weight loss and exercise) interventions, vii) ingestive behavior (taste perception and preference) testing, viii) cardiovascular assessments (e.g., echocardiography, endothelial function, carotid intima-media thickness); ix) measurement of stable isotope enrichment of metabolic substrates in blood and tissue samples, and x) mathematical modeling of tracer and non-tracer data to assess metabolic kinetics and -cell function. The Animal Model Research Core will provide services to investigators using murine models relevant to nutrition, including: i) maintaining breeding colonies of genetically modified mice, ii) training in breeding and animal husbandry, iii) biochemical and molecular analyses of blood and tissue samples, iii) body composition analyses, iv) genotyping, and v) metabolic phenotyping. The Biomolecular Analyses Core will provide services to permit structural identification and quantitation of nutrition-related biomolecules in blood and tissue samples. The Adipocyte Biology and Molecular Nutrition Core will provide adipose tissue morphology, adipocyte and muscle cell lines for culture, gene and protein expression, mitochondrial physiology, and training in specialized research techniques. The collaborative and synergistic relationships among our NORC research base and our four Core laboratories will be formalized by promoting “team science” to further encourage interdisciplinary approaches to address important issues in nutrition and obesity. In addition, the NORC will fund 4 Pilot & Feasibility Awards/year to junior faculty and help mentor them.

项目摘要/摘要 - 概述：该申请寻求继续为华盛顿大学医学院（WUSM）营养提供资金肥胖研究中心（NORC）。自从我们的NOC于1999年首次资助以来，它一直是 WUSM营养和肥胖研究的生长和发展。 NORC提供的基础设施创造了一个支持和刺激具有成本效益和高质量研究的环境，研究人员，职业发展与培训以及营养和临床活动之间的合作肥胖。我们的NORC拥有一个才华横溢的研究基础，由109位来自19的调查员组成部门。这些调查人员有179个营养/肥胖有关的补助金，每年产生4200万美元直接成本。我们打算继续发展营养和与肥胖有关的活动，并继续将最先进的基本和临床研究方法带到NORC研究人员。整体研究重点 WUSM NORC的是：1）肥胖症：病理生理，并发症和治疗学； 2）营养健康和疾病的代谢； 3）生长，发展和衰老。主要的新兴领域兴趣包括：4）肠道微生物组和5）社区健康。我们提出了一个行政核心和4 生物医学研究核心。临床科学研究核心将提供帮助：i）主题复杂代谢研究的招聘，设计和性能，ii）身体成分评估，iii）混合静脉示踪剂和马对溶液的混合，iv）收集组织（脂肪，肌肉，肠）样本，v）运动（耐力和力量）和身体表现测试，vi）生活方式（饮食操纵，减肥和运动）干预，vii）摄取行为（味觉感知和偏爱）测试，viii）心血管评估（例如，超声心动图，内皮功能，颈动脉内膜媒体厚度）; ix）测量稳定的同位素富集血液和组织样品中代谢底物的测量 X）示踪剂和非示踪数据的数学建模，以评估代谢动力学和细胞功能。动物模型研究核心将使用与营养，包括：i）维持一般修饰的小鼠的繁殖菌落，ii）畜牧业，iii）血液和组织样品的生化和分子分析，iii）身体成分分析，IV）基因分型和V）代谢表型。生物分子分析核心将提供允许血液和组织中营养相关生物分子的结构鉴定和定量的服务样品。脂肪细胞生物学和分子营养核心将提供脂肪组织形态，用于培养，基因和蛋白质表达，线粒体生理和训练的脂肪细胞和肌肉细胞系在专业研究技术中。我们的NORC研究之间的协作和协同关系基地和我们的四个核心实验室将通过促进“团队科学”以进一步鼓励来形式化跨学科方法解决营养和肥胖症中的重要问题。此外，诺克还将基金4授予初级教职员工的飞行员和可行性奖励/年。