Therapeutic Intermittent Compression Socket

治疗性间歇加压套筒

• 批准号: 7926268
• 负责人: Todd Richard Farrell
• 金额: $ 19.97万
• 依托单位: LIBERATING TECHNOLOGIES, INC.
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-04-15 至 2012-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7926268
• 关键词: Address; Amputation; Amputees; Biomedical Research; Blood Vessels; Blood flow; Cardiovascular system; Consumption; Cutaneous; Development; Devices; Diabetes Mellitus; Disease; Ensure; Evaluation; Free Will; Goals; Government; Healed; Health; Home environment; Hour; Housing; Human; Individual; Isolated limb perfusion; Knee; Lead; Life; Light; Limb Prosthesis; Limb Salvage; Limb structure; Literature; Lower Extremity; Malignant Neoplasms; Metabolic; Mission; Morbidity - disease rate; Nutrient; Operative Surgical Procedures; Outcome; Oxygen; Pain; Patients; Perfusion; Peripheral Vascular Diseases; Persons; Phase; Polymers; Population; Postoperative Period; Prevalence; Procedures; Process; Prosthesis; Psychosocial Factor; Pump; Quality of life; Reporting; Residual state; Rest; Risk; Shapes; System; Technology; Testing; Therapeutic; Tissues; Trauma; Ulcer; United States; Weight; Work; analog; compliance behavior; cost; design; energy density; experience; functional status; healing; human subject; improved; instrument; meetings; mortality; pressure; public health relevance; research and development; sedentary; sensor

DESCRIPTION (provided by applicant): Providing rapid intermittent compression (IC) therapy to persons with dysvascular amputation should reduce the number of reamputations that are performed by increasing blood flow to the residual limb. Increasing perfusion of the limb will both limit ulcer formation and promote ulcer healing. Patient compliance has been shown to be important to successful outcomes with IC therapy. Therefore, this project's long-term objective is to develop a rapid IC device that can be integrated into a prosthetic socket. Integrating the compression device into the socket will allow users to receive IC therapy without being confined to a chair for six hours a day and will thus increase patient compliance and enable the therapy to be performed in a preventative manner. Reducing the number of reamputations would maintain the quality of life of the patient by halting further limb loss, which has a negative impact on a number of functional and psychosocial variables. In addition, postoperative morbidities are caused by the underlying disease in half of major amputations and operative mortality rates as high as 17% have been reported. Finally, it has been calculated that $1.7 billion is spent annually on reamputation procedures performed on trans-tibial and trans-femoral amputees. By reducing the prevalence of reamputation though IC therapy we hope to improve the patient's quality of life and meet NIH's mission of improving human health through biomedical research. The objective of this project is to determine the feasibility of developing an actuator that can both mimic current commercial devices and be integrated into a prosthetic socket. One aim of the project is to develop an actuator that is capable of producing pressures similar to those that are created in current commercial devices while adhering to weight and power consumption requirements. To meet this goal we plan to investigate the use of electro-active polymers (EAPs) as they are light in weight, responsive, use little power and have a high energy density. Another aim is to develop an artificial residual limb that is instrumented with pressure sensors. The mock residual limb will allow us to quantify the pressures that are applied to the residual limb by both current commercial systems as well as the device that will be developed under this effort. This instrumented limb will likely use commercial-off the- shelf sensor technology to enable rapid design iterations without placing human subjects at risk during the development process. The final aim is to work with local prosthetics to integrate the actuator into a prosthetic socket and use the instrumented artificial limb to ensure that we meet our pressure, weight and power consumption goals. PUBLIC HEALTH RELEVANCE: The purpose of this project is to develop a device that provides rapid intermittent compression to the residual limb of amputees that do not have good blood flow in their limbs. The device will be built into the prosthetic socket to provide the user with portable therapy throughout the day, which will free the user from being confined to a chair for up to six hours each day to receive suggested amount of therapy. This device will reduce the number of ulcers that form, help those ulcers that do form to heal and will reduce the number of reamputation surgeries that need to occur by increasing blood flow in the limb, which will not only help to reduce the $1.7 billion that is spent each year in the United States related to but also improve the quality of life of amputees by maintaining their functional status and not requiring them to undergo further surgery.

描述（由申请人提供）：向血管截肢截肢的患者提供快速间歇性压缩（IC）治疗，应减少通过增加血液流动到残留肢体进行的反射数量。肢体灌注的增加既会限制溃疡的形成并促进溃疡愈合。已经证明患者依从性对IC治疗的成功结果很重要。因此，该项目的长期目标是开发一个可以集成到假肢插座的快速IC设备。将压缩装置集成到插座中将允许用户每天六个小时不限于椅子，因此可以提高患者的依从性，从而可以以预防措施进行治疗。减少反射数量将通过停止进一步的肢体损失来维持患者的生活质量，这对许多功能和社会心理变量产生负面影响。此外，术后病态是由一半的主要截肢率和手术死亡率高达17％引起的。最后，已经计算出17亿美元用于每年在跨式和跨股份截肢上执行的反射程序上。通过降低反射率的流行，我们希望改善患者的生活质量，并实现NIH通过生物医学研究改善人类健康的使命。该项目的目的是确定开发可以模仿当前商业设备并将其集成到假肢插座的执行器的可行性。该项目的目的之一是开发一个能够产生与当前商业设备中创建的压力相似的压力，同时遵守体重和功耗要求。为了实现这一目标，我们计划调查电动聚合物（EAP）的使用，因为它们的重量轻，反应迅速，使用的功率很少并且具有高能量密度。另一个目的是开发一个用压力传感器仪器的人造残留肢体。模拟残留的肢体将使我们能够通过当前的商业系统以及将在此工作中开发的设备量化对残差肢体的压力。该仪器的肢体可能会使用商业货架传感器技术来实现快速设计迭代，而不会在开发过程中置于人类受试者的危险中。最终目的是与当地的假肢合作，将执行器整合到假肢插座中，并使用仪器的人工肢体来确保我们满足压力，体重和功耗目标。 公共卫生相关性：该项目的目的是开发一种设备，该设备可为截肢者的残留肢体提供快速间歇性压缩，这些肢体的血液流量没有良好的血液流动。该设备将内置在假肢插座中，为用户全天提供便携式疗法，这将使用户每天最多被限制在椅子上，每天最多六个小时，以接受建议的治疗量。该设备将减少形成的溃疡数量，帮助那些确实形成愈合的溃疡，并通过增加肢体流动来减少需要进行的反射手术数量，这不仅将有助于减少与美国每年花费的17亿美元相关的17亿美元，还可以通过维持其功能性和不受其功能性的状态来改善其功能性的生活质量。