FUNCTION OF THE GAMMAHV68 M2 ANTIGEN

GAMMAHV68 M2 抗原的功能

• 批准号: 7349211
• 负责人: SAMUEL H SPECK
• 金额: $ 4.01万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-06-09 至 2007-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7349211
• 关键词: antigens; infection; lead; lymphoma; model; neoplasm /cancer

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Gammaherpesviruses are closely associated with the development of lymphoproliferative disease and lymphomas, as well as other cancers. The long-term goal of this research is to understand how gammaherpesviruses manipulate normal B or T cell development to persist within the lymphoid compartment of the infected host. Understanding the mechanisms used by gammaherpesviruses to persist in the infected host may lead to the development of strategies for interfering with chronic infection. The focus of the proposed studies on murine gammaherpesvirus 68 (gHV68; also referred to as MHV-68) represents an ongoing effort to develop a tractable small animal model for characterizing establishment and maintenance of gammaherpesvirus infection. The proposed studies focus on determining the function of one of the critical latency-associated antigens of gHV68, the M2 antigen).

该子项目是利用 NIH/NCRR 资助的中心拨款提供的资源的众多研究子项目之一。子项目和研究者 (PI) 可能已从另一个 NIH 来源获得主要资金，因此可以在其他 CRISP 条目中得到体现。列出的机构是中心的机构，不一定是研究者的机构。伽玛疱疹病毒与淋巴组织增生性疾病和淋巴瘤以及其他癌症的发展密切相关。这项研究的长期目标是了解伽马疱疹病毒如何操纵正常 B 或 T 细胞发育，使其在受感染宿主的淋巴室中持续存在。了解伽马疱疹病毒在受感染宿主体内持续存在的机制可能有助于制定干扰慢性感染的策略。拟议研究的重点是鼠伽马疱疹病毒 68（gHV68；也称为 MHV-68），代表了开发一种易于处理的小动物模型以表征伽马疱疹病毒感染的建立和维持的持续努力。拟议的研究重点是确定 gHV68 的关键潜伏期相关抗原之一（M2 抗原）的功能。