Comparative Effectiveness of Treatments for Localized Prostate Cancer

局限性前列腺癌治疗的比较效果

• 批准号: 8009296
• 负责人: DAVID F. PENSON
• 金额: $ 757.27万
• 依托单位: VANDERBILT UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-01 至 2013-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8009296
• 关键词: Comparative; Effectiveness; Treatments; Localized; Prostate

DESCRIPTION (provided by applicant): Prostate cancer is the most common solid tumor and is the second leading cause of cancer death among American men. While surgery, radiation and observation have all been deemed appropriate for newly diagnosed men, tremendous uncertainty remains regarding the optimal treatment. AHRQ's 2008 evidence report on the comparative effectiveness of therapies for localized prostate cancer concluded that "no one therapy can be considered the preferred treatment for localized prostate cancer due to the limitations in the body of evidence as well as the likely tradeoffs an individual patient must make between estimated treatment effectiveness, necessity and adverse effects." The existing literature is limited by its focus on older therapeutic modalities and by failure to control for individual patient characteristics and provider/hospital characteristics that may influence outcomes (quality of care). To fill these evidence gaps, we propose to expand a network of state tumor registries and a national observational disease registry to establish a new population-based cohort of men newly diagnosed with localized prostate cancer. We will prospectively measure key patient-reported outcomes, such as health-related quality of life and side-effects of therapy at diagnosis and 6 and 12 months later. We will also collect detailed medical record information, including clinical data, technical details of the interventions, complications, short-term cancer recurrence rates, and quality-of-care indicators. By using this approach, we will overcome limitations of the extant literature and achieve the following specific aims: 1. To compare the effectiveness of contemporary surgical and radiation techniques for localized prostate cancer in the cohort described above in terms of the 6- and 12-month patient-reported outcomes, side-effects and complications of treatment; 2. To identify patient level characteristics that may influence comparative effectiveness; and 3. To assess how the comparative effectiveness of the various therapies varies by quality of care received. PUBLIC HEALTH RELEVANCE: This study will compare the effectiveness of surgery and radiation for localized prostate cancer, the most common male cancer. It will focus on modern technologies and control for differences in patients and treatments that may affect outcomes. By figuring out what treatments "work best, in which patients and in whose hands", we will help men with prostate cancer make better decisions regarding their care.

描述（由申请人提供）：前列腺癌是最常见的实体瘤，是美国男性癌症死亡的第二大原因。虽然手术，辐射和观察都被认为适合新诊断的男性，但有关最佳治疗的巨大不确定性仍然存在。 AHRQ关于局部前列腺癌疗法的比较有效性的2008年证据报告得出结论：“由于证据体内的局限性以及个别患者必须在估计的治疗效率和不良影响之间做出的局限性，任何一种疗法可以被视为局部前列腺癌的首选治疗方法。”现有文献受到其关注较旧的治疗方式的限制，并且无法控制可能影响结果（护理质量）的个人患者特征和提供者/医院特征。 为了填补这些证据差距，我们建议扩大国家肿瘤登记局网络和国家观察疾病登记处，以建立一个新的基于人群的男性同类，该同类刚刚诊断出患有局部前列腺癌。我们将前瞻性地衡量患者报告的关键结果，例如与健康相关的生活质量和诊断时治疗的副作用以及6个月和12个月后的副作用。我们还将收集详细的病历信息，包括临床数据，干预措施的技术细节，并发症，短期癌症复发率和护理质量指标。通过使用这种方法，我们将克服现有文献的局限性，并实现以下特定目的：1。在上述人群中，根据6个和12个月的患者报告的副作用，副作用和治疗并发症，比较当代手术和辐射技术对局部前列腺癌的有效性； 2。确定可能影响比较有效性的患者水平特征； 3。评估各种疗法的比较有效性如何随收到的护理质量而变化。 公共卫生相关性：这项研究将比较手术和辐射对局部前列腺癌的有效性，这是最常见的男性癌症。它将着重于现代技术，并控制可能影响结果的患者和治疗的差异。通过弄清楚哪种治疗方法“最好的工作，在哪些患者和手中”，我们将帮助前列腺癌的男性在护理方面做出更好的决定。

项目成果

Comparison of Patient-reported Outcomes After External Beam Radiation Therapy and Combined External Beam With Low-dose-rate Brachytherapy Boost in Men With Localized Prostate Cancer.

• DOI: 10.1016/j.ijrobp.2018.05.043
• 发表时间: 2018-09-01
• 期刊: International journal of radiation oncology, biology, physics
• 作者: Lee DJ;Barocas DA;Zhao Z;Huang LC;Resnick MJ;Koyoma T;Conwill R;McCollum D;Cooperberg MR;Goodman M;Greenfield S;Hamilton AS;Hashibe M;Kaplan SH;Paddock LE;Stroup AM;Wu XC;Penson DF;Hoffman KE
• 通讯作者: Hoffman KE

Comment on "Responsibilities and Expectations: Considerations of Disclosure of Overlapping Operations".

对“责任与期望：重叠业务披露的考虑”发表评论。

• DOI: 10.1097/sla.0000000000004016
• 发表时间: 2021
• 期刊: Annals of surgery
• 影响因子: 9
• 作者: Stone,BenjaminV;Feng,David;Klaassen,Zachary;Barocas,DanielA;Wallis,ChristopherJD
• 通讯作者: Wallis,ChristopherJD

Five-year outcomes from a prospective comparative effectiveness study evaluating external-beam radiotherapy with or without low-dose-rate brachytherapy boost for localized prostate cancer.

一项前瞻性比较有效性研究的五年结果，该研究评估了外照射放射治疗（有或没有低剂量率近距离放射治疗）对局限性前列腺癌的影响。

• DOI: 10.1002/cncr.33388
• 发表时间: 2021
• 期刊: Cancer
• 影响因子: 6.2
• 作者: Pasalic,Dario;Barocas,DanielA;Huang,Li-Ching;Zhao,Zhiguo;Koyama,Tatsuki;Tang,Chad;Conwill,Ralph;Goodman,Michael;Hamilton,AnnS;Wu,Xiao-Cheng;Paddock,LisaE;Stroup,AntoinetteM;Cooperberg,MatthewR;Hashibe,Mia;O'Neil,BrockB