Diagnosis, Natural History, Management and tumor biology of Gastrinomas

胃泌素瘤的诊断、自然史、治疗和肿瘤生物学

• 批准号: 7967528
• 负责人: Robert Jensen
• 金额: $ 39.21万
• 依托单位: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/7967528
• 关键词: Carcinoid Tumor; Case Study; Classification; Consensus; Diagnosis; Disease; Endocrine Gland Neoplasms; Gastrinoma; Goals; Growth; Hyperparathyroidism; Incidence; Malignant - descriptor; Molecular; Multiple Endocrine Neoplasia Type 1; Natural History; Operative Surgical Procedures; Paper; Patients; Positioning Attribute; Positron-Emission Tomography; Prognostic Factor; Prospective Studies; Protocols documentation; Publishing; Series; Stomach; Tumor Biology; base; cohort; knowledge base; outcome forecast; symposium; tumor

Gastrinomas are the most common symptomatic, malignant PET in patients with or without MEN1 and sufficient numbers of these patients have been entered into our protocols to allow systematic assessment. Studies are now underway, evaluating the natural history of these tumors including the presentation and initial diagnosis and definition of factors determining prognosis. Our studies have identified a cohort of 25% of patients in whom the gastrinomas have aggressive growth and 25% who have multiple endocrine neoplasia type 1 (MEN1). During this year a prospective study of surgical treatment of hyperparathyroidism in MEN1 patients was completed showing that they have more severe disease than occurs in patients with MEN1 without gastrinomas; a prosepctive study of the occurrence of gastric carcinoids in MEN1/ZES patients was complete establishing the incidence of these tumors in these patients and recommending appropriate followup and prognostic factors for their presence, and a number of consensus conferences and position papers on treatment of various disease aspects were published.

胃瘤是有或没有MEN1的患者中最常见的症状性恶性PET，并且已将足够数量的这些患者纳入我们的方案中，以允许系统评估。现在正在进行研究，评估了这些肿瘤的自然历史，包括确定预后的因素的表现和初步诊断和定义。 我们的研究已经确定了胃瘤具有侵略性生长的25％的患者，其中25％的患者患有多种内分泌肿瘤1型（MEN1）。在今年，对MEN1患者的甲状旁腺功能亢进的手术治疗进行了前瞻性研究，表明他们的疾病比没有胃瘤的MEN1患者患有更严重的疾病。对MEN1/ZES患者中胃癌的发生的预倾向性研究已完成这些患者中这些肿瘤的发生率，并建议对其存在进行适当的随访和预后因素，并发布了许多共识会议和许多有关治疗各种疾病方面治疗的共识会议和位置论文。