Evaluation Of Treatments Of Drug Dependence In HIV Infected Patients

HIV 感染者药物依赖性治疗的评估

• 批准号: 7966764
• 负责人: Kenzie Preston
• 金额: $ 36.22万
• 依托单位: NATIONAL INSTITUTE ON DRUG ABUSE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/7966764
• 关键词: Agonist; Behavior; Behavior Therapy; Behavioral; Biological; Conduct Clinical Trials; Contracts; Drug Addiction; Drug usage; Evaluation; Goals; HIV; Heroin; Illicit Drugs; Individual; Interview; Maintenance; Methods; Monitor; Opiates; Opioid; Participant; Patients; Pharmacological Treatment; Preclinical Drug Evaluation; Questionnaires; Risk; Risk Behaviors; Risk-Taking; Structure; Substance abuse problem; Writing; contingency management; drug abstinence; effective therapy; intravenous drug use; reinforcer; substance abuser; therapy design; transmission process; vector

Intravenous drug use is a major vector of HIV transmission. Contingency management, a behavioral treatment in which participants earn reinforcers for drug abstinence, has been shown to reduce the use of illicit drugs and to be an effective treatment of drug dependence. Pharmacological treatment, such as opioid agonist maintenance, can reduce use of heroin and other opiates. We are conducting clinical trials of behavioral and pharmacological treatments designed to reduce drug use and other HIV-risk behaviors in individuals who are polydrug dependent. Participants complete the HIV-Risk Taking Behaviour Scale (HRBS) in written questionnaire form during the studies. Drug use is monitored in structured interviews and by drug screens on frequently collected biological matrices.

静脉吸毒是艾滋病毒传播的主要媒介。 应急管理是一种行为治疗，参与者可以通过这种行为获得戒毒强化物，已被证明可以减少非法药物的使用，并且是药物依赖的有效治疗方法。 药物治疗，例如阿片类激动剂维持治疗，可以减少海洛因和其他阿片类药物的使用。 我们正在开展行为和药物治疗的临床试验，旨在减少多种药物依赖者的药物使用和其他艾滋病毒风险行为。 参与者在研究期间以书面问卷形式填写艾滋病毒风险承担行为量表（HRBS）。 通过结构化访谈和对经常收集的生物基质进行药物筛选来监测药物使用情况。