Facilitating Access to Information on Human Proteins and Their Phosphorylation

促进获取有关人类蛋白质及其磷酸化的信息

• 批准号: 7965216
• 负责人: James Shaw
• 金额: $ 11.56万
• 依托单位: DIVISION OF BASIC SCIENCES - NCI
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/7965216
• 关键词: Access to Information; Adoption; Antibodies; Architecture; Area; Back; Basic Science; Biological; Biology; Cancer Biology; Cells; Communities; Computer software; Computers; Databases; Education; Eukaryotic Cell; Generations; Human; Information Resources; Internet; Interruption; Linux; Maintenance; Phospho-Specific Antibodies; Phosphorylation; Phosphorylation Site; Pilot Projects; Policies; Proteins; Research Infrastructure; Resources; Running; Services; Site; Source; United States National Institutes of Health; Update; clinical Diagnosis; computerized data processing; experience; human disease; interest; novel strategies; open source; pre-clinical research; web site; web-accessible

The MPR web site <A HREF="http://mpr.nci.nih.gov/">http://mpr.nci.nih.gov<A> has continued to be widely utilized by the biological community and its utilization continues to grow at a robust rate. This year the site continued to undergo a major multi-component improvement in infrastructure. The fundamental transition from the Microsoft .NET framework to Ruby on Rails (ROR) is largely complete, without any interruption in service to the community. The rationale was that the proprietary.NET architecture has not evolved to be nearly as efficient in implementation or alteration as was widely anticipated. In contrast, ROR is a very powerful, open-source framework for developing database-backed web applications. The emerging evidence indicated to us that ROR was on a trajectory similar to that of Linux in its early days, and was becoming the framework of choice for database driven web applications like MPR. Considerable effort has been involved in our enhancing the education of the staff of NCIWeb in this area; moreover the NIH/NCI policies and conventions often constrain adoption of new approaches, which we have experienced in this case and have had to develop robust workaround. Moreover, we have also been interacting with CIT investigating the feasibility of supporting these services on CIT servers, which would further broaden their usefulness to the NIH community more generally. The other key progress is developing approaches for semi-automatic update of web site information via more computer-facilitated exchange of information with companies. In the long run this well be essential for efficient maintenance and updating of information on the site. However, most of the companies generating such antibodies are not sufficiently software/database savvy to be highly interested in this. But one of the excellent high-volume companies has been motivated to explore such options and we are close to completion of the pilot project in semi-automated update.

MPR网站<a href =“ http://mpr.nci.nih.gov/”> http://mpr.nci.nih.gov <a>继续被生物群落及其利用率继续以稳健的利率增长。今年，该网站继续在基础设施方面经历了重大的多组分改进。从Microsoft .NET框架到Ruby on Rails（ROR）的基本过渡在很大程度上是完整的，而没有任何为社区服务的中断。 理由是，专有的.NET体系结构并没有像广泛预期的那样在实施或更改方面发挥作用。相比之下，ROR是一个非常强大的开源框架，用于开发数据库支持的Web应用程序。新兴的证据向我们表明，ROR的轨迹与Linux的早期类似，并且正成为MPR等数据库驱动的Web应用程序的首选框架。我们加强了该领域NCIWEB员工的教育，已经付出了巨大的努力。此外，NIH/NCI政策和惯例通常会限制我们在这种情况下经历的新方法的采用，并且不得不发展强大的解决方法。此外，我们还一直在与CIT调查CIT服务器上支持这些服务的可行性，这将进一步扩大对NIH社区的有用性。另一个关键的进展是开发方法，通过与公司进行更多计算机相关的信息交换，以半自动更新网站信息。从长远来看，这对有效维护和更新网站上的信息至关重要。但是，大多数生成此类抗体的公司都不足够的软件/数据库对此非常感兴趣。但是，一家出色的高批量公司之一是有动力探索这种选择的，我们接近半自动化更新中的试点项目。