Clinical

临床

• 批准号: 7685017
• 负责人: Paul A. Goepfert
• 金额: $ 38.66万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-06-15 至 2014-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7685017
• 关键词: AIDS/HIV problem; Acquired Immunodeficiency Syndrome; Adherence; Advertisements; Anti-Retroviral Agents; Appointment; Area; Arts; Basic Science; Behavioral; Behavioral Sciences; Biometry; Characteristics; Clinic; Clinical; Clinical Research; Collaborations; Collection; Complex; Computer software; Computers; DNA Sequence; Data; Data Analyses; Databases; Development; Discipline; Electronics; Ensure; Equipment; Faculty; Fostering; Funding; HIV; Health Personnel; Health Services Accessibility; Health behavior; Healthcare; Human Resources; Immune response; Individual; Informatics; Institution; International; Investigation; Lead; Leadership; Link; Mails; Medical Records; Mental disorders; Mentors; Methods; Newsletter; Observational Study; Operative Surgical Procedures; Outcome; Pathogenesis; Patients; Pharmaceutical Preparations; Plasmapheresis; Play; Policies; Positioning Attribute; Process; Productivity; Protocols documentation; Publications; Publishing; Research; Research Design; Research Methodology; Research Personnel; Research Subjects; Research Training; Resources; Role; Sampling; Seasons; Services; Shipping; Ships; Site; Specimen; Stream; Students; Substance abuse problem; System; Techniques; Technology; Training; Translational Research; Update; Work; Zambia; base; career; cohort; computerized; cost effectiveness; design; improved; innovation; interest; meetings; member; prospective; quality assurance; repository; research study; response; skills; statistics; success; systems research; vaccine development; virology; web site

The Clinical Core has been in operation for twenty years to provide services that foster the translational interface between basic science, clinical, behavioral, and epidemiologic investigators and HIV-infected patients. The Specific Aims of the Clinical Core are: 1. To provide a Comprehensive Specimen Repository offering the efficient collection, processing, storage, quality assurance tracking, distribution, and shipping of clinical specimens obtained from wellcharacterized patients for collaborative investigations involving multiple research disciplines. 2. To provide an innovative Computerized Database and Informatics Service¿the resources and equipment to store and access complex, interactive data and the expertise to assist with study design, identify subjects who meet entry criteria for research protocols, conduct appropriate data analyses and provide detailed and relevant interpretation of results. 3. To establish new methods and technologies to make clinical samples more readily accessible to CFAR members realizing that despite the numerous successes we have had in fostering innovative translational research, we must strive to improve this process. 4. To provide Research Training Services to support all levels (from students to research staff to seasoned faculty updating their skills) of domestic and international clinical research. While each of these services has been in operation since the beginning of our CFAR, each continues to grow and diversify substantially in response to investigator needs. Publications requiring Clinical Core services have continued to increase every year during the last funding period. Specimens are integrally linked with information in the Computerized Database, and this synergy has played an important role in new discoveries related to HIV pathogenesis, understanding immune responses and vaccine development. Recently, the medical record system and research database have become fully electronic, utilizing software completely designed and managed by CFAR investigators with expertise in informatics, statistics and computer technology. These advancements place CFAR investigators in a unique position to lead collaborative clinical database and outcomes-based national and international projects, and to contribute meaningfully to policy debates regarding health care access and cost-effectiveness. A variety of domestic research training services have been strengthened, while international research training efforts are best exemplified by Clinical Core support, in full collaboration with the International Core. These Clinical Core services are essential for the conduct of a vast array of HIV/AIDS research at DAB and around the world.

临床核心已运行二十年，提供促进翻译界面的服务 基础科学、临床、行为和流行病学研究人员与艾滋病毒感染者之间的合作。 临床核心的目标是： 1. 提供综合样本库，提供高效的采集、处理、存储、 对经过充分表征的临床标本进行质量保证跟踪、分发和运输 患者进行涉及多个研究学科的合作研究。 2. 提供创新的计算机化数据库和信息服务¿资源和 用于存储和访问复杂的交互式数据的设备以及协助研究设计的专业知识， 确定符合研究方案进入标准的受试者，进行适当的数据分析和 对结果提供详细且相关的解释。 3.建立新的方法和技术，使临床样本更容易获得CFAR 成员们认识到，尽管我们在促进创新转化方面取得了许多成功 研究中，我们必须努力改进这个过程。 4. 提供研究培训服务以支持各个级别（从学生到研究人员再到经验丰富的人员） 教师更新他们的技能）国内和国际临床研究。 虽然这些服务自我们的 CFAR 开始以来一直在运营，但每项服务都在不断增长和发展 为了满足研究者的需求，需要临床核心服务的出版物仍在继续。 在上一个资助期间每年都会增加样本与信息中的信息紧密相连。 计算机化数据库，这种协同作用在艾滋病毒相关新发现中发挥了重要作用 发病机制、了解免疫反应和疫苗开发最近，医疗记录系统和 研究数据库已完全电子化，使用完全由 CFAR 设计和管理的软件 具有信息学、统计和计算机技术专业知识的研究人员将 CFAR 置于首位。 研究人员处于领导协作临床数据库和基于结果的国家和国际的独特地位 项目，并为有关医疗保健获取和成本效益的政策辩论做出有意义的贡献。 国内各类科研培训服务不断加强，国际科研培训力度不断加大 与国际核心服务充分合作的临床核心支持就是最好的例证。 对于 DAB 和世界各地开展大量艾滋病毒/艾滋病研究至关重要。