Exploring Common Linkage Regions in Lung Cancer and COPD

探索肺癌和慢性阻塞性肺病的共同关联区域

基本信息

批准号：
7922858
负责人：
Michele L. Cote
金额：
$ 10.75万
依托单位：
WAYNE STATE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
起止时间：
2009-09-30 至 2012-09-29
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7922858
关键词：
12p Affect Bioinformatics Cancer Etiology Case-Control Studies Cause of Death Cessation of life Chromosomes Chromosomes, Human, Pair 6 Chronic Obstructive Airway Disease DNA Data Development Diagnosis Discipline Disease Etiology Family Family history of Future Genes Genetic Genotype Goals Inherited Knowledge Larynx Link Lung Lung Adenocarcinoma Lung diseases Malignant Neoplasms Malignant neoplasm of lung Malignant neoplasm of pharynx Maps Occupational Pathway interactions Population Predisposition Recording of previous events Recruitment Activity Relative (related person)Reporting Research Research Personnel Resources Respiratory physiology Risk Risk Factors Survival Rate Susceptibility Gene Symptoms Techniques Technology Testing United States Variant Woman cigarette smoking follow-up genetic analysis genetic epidemiology genetic linkage analysis genetic variant improved insight interest novel skills

项目摘要

DESCRIPTION (provided by applicant): Lung cancer and Chronic Obstructive Pulmonary Disease (COPD) are two of the most common and most deadly pulmonary diseases. There is no cure for COPD, and it represents the 4th leading cause of death in the United States. Lung cancer is the leading cause of cancer-related deaths in the US, and little improvement has been made in diagnosis or treatment, resulting in a dismal 15% five-year overall survival rate. The most important risk factor for both diseases is cigarette smoking; however, occupational factors and family history are also known to increase risk. Additionally, a personal history of COPD has consistently been shown to increase risk of lung cancer. To identify chromosomal regions that are inherited with disease, several groups have collected DMA from families with multiple affected relatives and performed linkage analyses. In COPD, a region on chromosomes 6q-ter has been associated with lung function and COPD. In lung cancer, a single linkage analysis reported evidence of linkage between a region also on chromosome 6q and lung, laryngeal and pharyngeal cancers. These linkage studies have identified regions of interest and may help future research pinpoint genes that are associated with both lung cancer and COPD. However, these regions are still quite large and encompass hundreds of genes, requiring further research to isolate susceptibility genes. The overall goal of this research plan is to investigate the importance of chromosome 6 on lung cancer and COPD development. We hypothesize that in addition to cigarette smoking, the similarities between COPD and lung cancer development arise from a common genetic pathway(s). We believe that using a variety of statistical techniques and newly available resources, such as the HapMap, will provide novel insight to the etiology of these conditions and potentially identify new targets to improve treatment and survival. This proposal describes a five-year research plan to acquire knowledge and skills to become an independent cancer researcher, with specialized skills in the analysis of genetic data. This project uses existing data and DNA from a case-control study of women with adenocarcinoma of the lung, including those with both lung cancer and COPD, lung cancer only, COPD only, and cancer and COPD-free controls. Additionally, a small number of COPD cases will be prospectively collected. The scope of this project encompasses several disciplines, including epidemiology, genetics, and bioinformatics.

描述（由申请人提供）：肺癌和慢性阻塞性肺病（COPD）是两种最常见和最致命的肺部疾病。慢性阻塞性肺病无法治愈，它是美国第四大死因。肺癌是美国癌症相关死亡的主要原因，而诊断或治疗方面几乎没有取得任何进展，导致五年总生存率仅为 15%。这两种疾病最重要的危险因素是吸烟。然而，职业因素和家族史也会增加风险。此外，慢性阻塞性肺病的个人病史一直被证明会增加患肺癌的风险。为了识别疾病遗传的染色体区域，几个小组从有多个受影响亲属的家庭中收集了 DMA 并进行了连锁分析。在慢性阻塞性肺病中，染色体 6q-ter 上的一个区域与肺功能和慢性阻塞性肺病有关。在肺癌中，单一连锁分析报告了 6q 染色体上的一个区域与肺癌、喉癌和咽癌之间存在连锁的证据。这些连锁研究已经确定了感兴趣的区域，并可能有助于未来的研究查明与肺癌和慢性阻塞性肺病相关的基因。然而，这些区域仍然相当大，包含数百个基因，需要进一步研究来分离易感基因。该研究计划的总体目标是调查 6 号染色体对肺癌和 COPD 发展的重要性。我们假设，除了吸烟之外，慢性阻塞性肺病和肺癌发展之间的相似性还源于共同的遗传途径。我们相信，使用各种统计技术和新可用的资源（例如 HapMap）将为这些疾病的病因学提供新的见解，并有可能确定改善治疗和生存的新目标。该提案描述了一项为期五年的研究计划，旨在获得知识和技能，成为一名独立的癌症研究人员，并具备遗传数据分析的专业技能。该项目使用来自肺腺癌女性病例对照研究的现有数据和 DNA，其中包括同时患有肺癌和慢性阻塞性肺病的女性、仅患有肺癌、仅患有慢性阻塞性肺病的女性以及无癌症和慢性阻塞性肺病的对照女性。此外，还将前瞻性收集少量慢性阻塞性肺病病例。该项目的范围涵盖多个学科，包括流行病学、遗传学和生物信息学。