PERLECAN AND HEPARANASE IN CARTILAGE GROWTH AND HEALING

PERLECAN 和乙酰肝素酶在软骨生长和愈合中的作用

• 批准号: 7959490
• 负责人: MARY C FARACH-CARSON
• 金额: $ 31.59万
• 依托单位: UNIVERSITY OF DELAWARE
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-06-01 至 2010-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7959490
• 关键词: Address; Adult; Age; Biology; Cartilage; Centers of Research Excellence; Chondrogenesis; Complex; Computer Retrieval of Information on Scientific Projects Database; Degenerative polyarthritis; Embryonic Development; Engineering; Enzymes; Funding; Grant; Growth; Healed; Heparan Sulfate Proteoglycan; Heparitin Sulfate; In Vitro; Injury; Institution; Maintenance; Mentors; Mutation; Organism; Play; Process; Research; Research Personnel; Resources; Role; Science; Source; Structure; United States National Institutes of Health; Woman; healing; heparanase; mouse model; perlecan; professor

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. In the first project, Dr. Farach-Carson proposes to define precisely the structural and functional roles that perlecan (Pln) and its associated heparan sulfate (HS) proteoglycan chains play in cartilage biology. HS proteoglycans have recently emerged as key regulators of cartilage biology and play critical roles during embryonic development, in maintenance of cartilage structures in the adult organism, and in regrowth of damaged cartilage resulting from age, osteoarthritis or injury. Using a combination of in vitro chondrogenesis models and mice harboring mutations in Pln or HS biosynthetic enzymes, Dr. Farach-Carson et al. will address the hypothesis that Pln and heparanase I are essential players in normal chondrogenesis and cartilage healing, and that their complex roles in these processes are associated with specialized functions encrypted within the various domains and require the presence and turnover of HS. Dr. Farach-Carson is a full professor and will not have a mentor.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 在第一个项目中，Farach-Carson博士建议精确定义Perlecan（PLN）及其相关的硫酸乙酰肝素（HS）蛋白聚糖链在软骨生物学中发挥作用的结构和功能作用。 HS蛋白聚糖最近已成为软骨生物学的关键调节剂，并在胚胎发育过程中起关键作用，在成人生物体中的软骨结构维持以及因年龄，骨关节炎或损伤而导致的软骨受损的再生中。 Farach-Carson等人使用PLN或HS Biosynthetic酶中携带突变的体外软骨发生模型和具有突变的小鼠的组合。将解决以下假设：PLN和乙酰肝素I是正常软骨发生和软骨愈合的重要参与者，并且它们在这些过程中的复杂作用与在各个领域中加密的专门功能有关，并且需要HS的存在和营业额。 Farach-Carson博士是一位完整的教授，将没有导师。