M TUBERCULOSIS ADENOSINE KINASE AND ANTI-MICROBIAL NUCLEOSIDE ANALOGS

结核分枝杆菌腺苷激酶和抗微生物核苷类似物

• 批准号: 7955086
• 负责人: RONGBAO LI
• 金额: $ 0.64万
• 依托单位: CORNELL UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-04-01 至 2010-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7955086
• 关键词: Adenosine Kinase; Anabolism; Complex; Computer Retrieval of Information on Scientific Projects Database; Dihydrofolate Reductase; Enzymes; Folate; Funding; Goals; Grant; Institution; Molecular; Mycobacterium tuberculosis; Nucleosides; Pathway interactions; Research; Research Personnel; Resources; Source; Structure; Tuberculosis; United States National Institutes of Health; analog; antimicrobial; base; enzyme pathway; mycobacterial; novel; nucleoside analog; pathogen; protein complex; structural biology; therapeutic target; tuberculosis treatment

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The overall goal of the projects is to study the crystal structure of the enzymes from the pathway of folate biosynthesis and nucleoside salvage in Mycobacterial tuberculosis, an opportunistic pathogen that causes TB and to develop these enzymes as therapeutic targets to treat TB. We have obtained crystals of some the key enzymes in these pathways, including dihydrofolate reductase and adenosine kinase in complexes with their substrate or substrate analogs. The crystal structure of the protein complexes will provide the molecular basis for developing novel compounds that are highly potent and selective against M. tuberculosis and are potentially useful for the TB treatment.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 该项目的总体目标是研究结核分枝杆菌（一种导致结核病的机会性病原体）叶酸生物合成和核苷回收途径中酶的晶体结构，并开发这些酶作为治疗结核病的治疗靶点。 我们已经获得了这些途径中一些关键酶的晶体，包括二氢叶酸还原酶和腺苷激酶与其底物或底物类似物的复合物。 蛋白质复合物的晶体结构将为开发新型化合物提供分子基础，这些化合物对结核分枝杆菌具有高效和选择性，并且可能用于结核病治疗。