M TUBERCULOSIS ADENOSINE KINASE AND ANTI-MICROBIAL NUCLEOSIDE ANALOGS

结核分枝杆菌腺苷激酶和抗微生物核苷类似物

基本信息

批准号：
7955086
负责人：
RONGBAO LI
金额：
$ 0.64万
依托单位：
CORNELL UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
起止时间：
2009-04-01 至 2010-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7955086
关键词：
Adenosine Kinase Anabolism Complex Computer Retrieval of Information on Scientific Projects Database Dihydrofolate Reductase Enzymes Folate Funding Goals Grant Institution Molecular Mycobacterium tuberculosis Nucleosides Pathway interactions Research Research Personnel Resources Source Structure Tuberculosis United States National Institutes of Health analog antimicrobial base enzyme pathway mycobacterial novel nucleoside analog pathogen protein complex structural biology therapeutic target tuberculosis treatment

Adenosine Kinase Anabolism Complex Computer Retrieval of Information on Scientific Projects Database Dihydrofolate Reductase Enzymes Folate Funding Goals Grant Institution Molecular Mycobacterium tuberculosis Nucleosides Pathway interactions Research Research Personnel Resources Source Structure Tuberculosis United States National Institutes of Health analog antimicrobial base enzyme pathway mycobacterial novel nucleoside analog pathogen protein complex structural biology therapeutic target tuberculosis treatment

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项目摘要

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The overall goal of the projects is to study the crystal structure of the enzymes from the pathway of folate biosynthesis and nucleoside salvage in Mycobacterial tuberculosis, an opportunistic pathogen that causes TB and to develop these enzymes as therapeutic targets to treat TB. We have obtained crystals of some the key enzymes in these pathways, including dihydrofolate reductase and adenosine kinase in complexes with their substrate or substrate analogs. The crystal structure of the protein complexes will provide the molecular basis for developing novel compounds that are highly potent and selective against M. tuberculosis and are potentially useful for the TB treatment.

该副本是利用众多研究子项目之一由NIH/NCRR资助的中心赠款提供的资源。子弹和调查员（PI）可能已经从其他NIH来源获得了主要资金，因此可以在其他清晰的条目中代表。列出的机构是对于中心，这不一定是调查员的机构。该项目的总体目标是研究分枝杆菌结核病中叶酸生物合成和核苷拯救途径的酶的晶体结构，这是一种机会性的病原体，该病原体会导致TB并开发这些酶作为治疗TB的治疗靶标。我们已经在这些途径中获得了某些关键酶的晶体，包括与其底物或底物类似物的复合物中的二氢叶酸还原酶和腺苷激酶。蛋白质复合物的晶体结构将为开发针对结核分枝杆菌的高效和选择性的新型化合物提供分子基础，并可能对结核病治疗有用。