STRUCTURE AND FUNCTION OF PYK2 IN INTEGRIN SIGNALING

PYK2 在整合素信号转导中的结构和功能

• 批准号: 7721257
• 负责人: RONGBAO LI
• 金额: $ 0.35万
• 依托单位: CORNELL UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-05-15 至 2009-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7721257
• 关键词: Computer Retrieval of Information on Scientific Projects Database; Funding; Goals; Grant; Institution; Integrins; Osteoclasts; Osteolysis; PTK2B gene; Proteins; Research; Research Personnel; Resources; Signal Transduction; Source; Structure; United States National Institutes of Health; X-Ray Crystallography; molecular recognition; structural biology; three dimensional structure

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The long-term goal of the proposed research is to understand the structural biology and function of PYK2 in the integrin signaling during osteoclast activation, explore the relationship among its structure, function and dynamics, and exploit this relation for specific inhibition of PYK2 required for osteolysis. Towards this goal, we have initiated a collaborative research effort to study the three-dimensional structure of PYK2 by X-ray crystallography and the molecular recognition of the associated proteins by PYK2.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 拟议的研究的长期目标是了解整骨细胞激活期间整联蛋白信号传导中PYK2的结构生物学和功能，探索其结构，功能和动态之间的关系，并利用这种关系，以对PYK2的特定抑制作用的骨化溶液所需的抑制作用。为了实现这一目标，我们开始了一项协作研究工作，以通过X射线晶体学研究PYK2的三维结构，并通过PYK2对相关蛋白的分子识别。