MRS DETECTS METABOLIC DYSFUNCTION AFTER BRAIN INJURY

MRS 检测到脑损伤后代谢功能障碍

• 批准号: 7955672
• 负责人: Paul M Vespa
• 金额: $ 1.36万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-08-01 至 2010-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7955672
• 关键词: Admission activity; Area; Atrophic; Brain; Brain Injuries; Computer Retrieval of Information on Scientific Projects Database; Correlation Studies; Enrollment; Functional disorder; Funding; Grant; Hematoma; Hippocampus (Brain); Hospitals; Institution; MRI Scans; Measures; Metabolic; Metabolism; Modeling; Neurologic; Parietal; Patients; Research; Research Personnel; Resources; Sampling; Source; Thick; Time; Traumatic Brain Injury; United States National Institutes of Health; case-based; computational anatomy; gray matter; psychologic; white matter

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Traumatic brain injury patients enrolled into the UCLA Brain Injury Research Center receive multiple brain MRI scans at time of admission, during ICU stay, and again during long-term followup after hospital discharge. Evidence to date demonstrates significant localized and regional white-matter and grey-matter atrophy in increments over time in these patients. We will seek to analyze volumetrics and cortical extractions using the LONI Pipeline V1 in the whole brain and in selected regions by hemisphere, including frontal, basal frontal, hippocampal, parietal and occipital regions, and we will also examine volumes and volume changes in hematoma and perihematomal areas on a case-by-case basis. Resulting volumes and cortical thicknesses will be analyzed by linear mixed modeling and by correlation studies with measures of metabolism and neurological and psychological status obtained in the same patient sample.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 加入加州大学洛杉矶分校脑损伤研究中心的创伤性脑损伤患者在入院时、入住 ICU 期间以及出院后的长期随访期间接受多次脑部 MRI 扫描。 迄今为止的证据表明，这些患者的局部和区域性白质和灰质萎缩随着时间的推移而逐渐增加。 我们将寻求使用 LONI Pipeline V1 在整个大脑和半球选定区域（包括额叶、基底额叶、海马、顶叶和枕叶区域）分析体积和皮质提取，我们还将检查血肿和体积的体积和体积变化。血肿周围区域根据具体情况而定。 将通过线性混合模型以及与同一患者样本中获得的代谢以及神经和心理状态测量值的相关性研究来分析所得体积和皮质厚度。