QUESTION OR TRAINING REQUEST FOR THE YEAST RESOURCE CENTER

对酵母资源中心的问题或培训请求

• 批准号: 7957701
• 负责人: Timothy G Formosa
• 金额: $ 0.48万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-01 至 2010-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7957701
• 关键词: Biology; Computer Retrieval of Information on Scientific Projects Database; Funding; Fungal Genome; Grant; Hybrids; Institution; Phosphotyrosine; Proteins; Research; Research Personnel; Resources; Source; Training; United States National Institutes of Health; Yeasts; interest; research study; src Homology Region 2 Domain; yeast protein

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We are interested in studying interactions with a structural domain of S cerevisiae Spt6 (the only known SH2 domain in yeast). Spt6 has several structural domains, so it is not clear that previous experiments that used the whole Spt6 protein will be relevant. As yeast are not known to have phosphotyrosine, it is of interest to know what this SH2 domain interacts with. Is the YRC an appropriate collaborator for a 2-hybrid screen with a subdomain of a yeast protein like this?

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 我们有兴趣研究与S Cerevisiae Spt6（酵母中唯一已知的SH2结构域）的结构结构域的相互作用。 SPT6具有多个结构域，因此尚不清楚以前使用整个SPT6蛋白的实验是否相关。由于酵母尚不知道磷酸酪氨酸，因此知道SH2域与什么相互作用是很有趣的。 YRC是否是具有类似酵母蛋白的子域的2 Hybrid屏幕的适当合作者？