FAMILIAL IGA NEPHROPATHY: GENETIC AND FAMILIAL STUDIES

家族性 IGA 肾病：遗传和家族研究

• 批准号: 7603178
• 负责人: BRUCE A JULIAN
• 金额: $ 0.69万
• 依托单位: UNIVERSITY OF ALABAMA AT BIRMINGHAM
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-03-01 至 2008-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7603178
• 关键词: Biochemical Genetics; Biostatistics Core; Blood; Blood Pressure; Cell Line; Clinical; Computer Retrieval of Information on Scientific Projects Database; Creatinine; Development; Disease; Enrollment; Foundations; Funding; Future; Genetic; Grant; Height; Immunoglobulin A; Institution; Kentucky; Kidney Diseases; Measures; Outpatients; Participant; Pathogenesis; Physicians; Physicians' Offices; Proteins; Research; Research Personnel; Resources; Sampling; Serum; Source; Tennessee; United States National Institutes of Health; Urinalysis; Urine; Venous; Visit; Weight; base; programs; urinary

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This study will provide clinical resources for the Clinical and Biostatistics Core of a multicenter Program Project that is comprised of three projects investigating the genetic and biochemical aspects of IgA nephropathy. The program Project will enroll about 1515 participants, but only about 1000 at UAB. About 550 of the UAB participants will be seen in the GCRC for their single physician visit, while about 450 UAB participants will be seen during field trips at physician offices outside of Birmingham. The other 515 participants will be seen by investigators in Tennessee and Kentucky. The Specific Aims of this study are: 1. Measure blood pressure, height, and weight for participants seen in the UAB GCRC. 2. Collect venous blood and urine samples during the one outpatient visit for the participants seen at UAB GCRC. 3. Perform urinalysis, serum creatinine concentration, and urinary protein and creatinine concentrations for all 1515 participants using blood and urine samples either collected in the UAB GCRC or by UAB investigators during field trips, or sent from participating outside centers. 4. Establish EBV-transofrmed cell lines for some participants, to be selected by the investigators based upon their potential to contribute to the genetic studies of familial IgA nephropathy. The findings from this Program Project will substantially increase the understanding of the pathogenesis of a common renal disease and may be the foundation for future development of a disease-specific therapy.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 这项研究将为多中心项目的临床和生物统计学核心提供临床资源，该项目由三个研究 IgA 肾病遗传和生化方面的项目组成。该项目将招收约 1515 名参与者，但 UAB 只招收约 1000 名参与者。大约 550 名 UAB 参与者将在 GCRC 进行单次医生就诊，而大约 450 名 UAB 参与者将在伯明翰以外的医生办公室进行实地考察。其他 515 名参与者将接受田纳西州和肯塔基州调查人员的会面。 本研究的具体目标是： 1. 测量 UAB GCRC 中参与者的血压、身高和体重。 2. 在 UAB GCRC 就诊的参与者的一次门诊就诊期间收集静脉血和尿液样本。 3. 使用 UAB GCRC 或 UAB 研究人员在实地考察期间收集的或从参与的外部中心发送的血液和尿液样本，对所有 1515 名参与者进行尿液分析、血清肌酐浓度以及尿蛋白和肌酐浓度。 4. 为一些参与者建立 EBV 转化细胞系，由研究人员根据其对家族性 IgA 肾病遗传研究做出贡献的潜力进行选择。 该计划项目的研究结果将大大增加对常见肾脏疾病发病机制的了解，并可能为未来开发疾病特异性疗法奠定基础。