Core 2: Biospecimen, Metabolomics, and Pathology Core

核心 2：生物样本、代谢组学和病理学核心

• 批准号: 10711640
• 负责人: Ian S. Hagemann
• 金额: $ 13.04万
• 依托单位: WASHINGTON UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-08-23 至 2028-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10711640
• 关键词: Award; Biostatistics Core; Blood; Cancer Center; Cancer Model; Cancer Patient; Catalogs; Cells; Characteristics; Clinical; Clinical Data; Collaborations; Collection; Communities; Consent; Correlative Study; Credentialing; Data; Databases; Development; Diagnosis; Disease; Eligibility Determination; Endometrial Carcinoma; Ensure; Equipment and supply inventories; Equity; Evaluation; Experimental Designs; Freezing; Future; Goals; Grant; Infrastructure; Institution; Institutional Review Boards; Isotopes; Leadership; Link; Liquid substance; Manuscripts; Metabolic; Methods; New Mexico; Newly Diagnosed; Nucleic Acids; Oklahoma; Organoids; Outcome; Pathology; Patients; Peer Review; Plasma; Preparation; Process; Prognostic Factor; Protocols documentation; Publications; Qualifying; Recurrence; Research; Research Design; Research Personnel; Research Project Grants; Resources; Route; Sampling; Serum; Services; Specimen; Standardization; Structure; Time; Tissues; Translational Research; Universities; Validation; Washington; Work; anticancer research; biobank; career; clinical database; data interoperability; data sharing; experience; genome sequencing; metabolomics; model development; operation; patient derived xenograft model; preservation; prevent; programs; prospective; sample collection; secondary analysis; success; tool; whole genome

PROJECT SUMMARY/ABSTRACT The goal of the Biospecimen, Metabolomics, and Pathology Core (BMP Core) is to create a federated, multi- institutional resource to provide high-quality, clinically annotated biospecimens, metabolomic analyses, and expert pathology review to all research projects in this SPORE application as well as future SPORE-sponsored DRP and CEP projects, while serving as an unparalleled biospecimen resource to the broader endometrial cancer research community. The Core will provide specific tissue and biosample-related services for each SPORE project. In addition, the BMP Core will prospectively build a biospecimen resource bank at WUSTL, OUHSC, and UNM by identifying cases of new and recurrent endometrial cancer at the participating institutions and facilitating the consent and procurement process. Tissue and fluid biospecimens from these patients will be collected, processed, and stored by leveraging the extensive infrastructure of existing biorepositories at the participating institutions. Clinical data will be collected prospectively by integrating with and extending existing clinical databases. Interactions with the Biostatistics Core will ensure interoperability of data tables maintained at each institution. The BMP Core will provide access to the world-class Center for Metabolomics and Isotope Tracing at WUSTL. Validated methods for sample processing and preservation, focused on optimizing metabolic analyses, will be provided to increase the scientific utility of all biospecimens collected. A transparent and equitable mechanism to publicize existing biospecimen resources and evaluate any request for their use will be implemented. As such, the BMP Core will supplement existing cancer center resources with focused expertise and effort to comprehensively collect, annotate, quality review, and distribute biospecimens specifically for translational endometrial cancer research.

项目概要/摘要 生物样本、代谢组学和病理学核心（BMP 核心）的目标是创建一个联合的、多 提供高质量、临床注释的生物样本、代谢组学分析和 对此 SPORE 应用程序以及未来 SPORE 赞助的所有研究项目进行专家病理学审查 DRP 和 CEP 项目，同时作为更广泛的子宫内膜无与伦比的生物样本资源 癌症研究团体。核心将为每个人提供特定的组织和生物样本相关服务 孢子项目。此外，BMP核心将前瞻性地在WUSTL建立一个生物样本资源库， OUHSC 和 UNM 通过识别参与机构的新发和复发子宫内膜癌病例 并促进同意和采购过程。来自这些患者的组织和体液生物样本将 通过利用现有生物样本库的广泛基础设施来收集、处理和存储 参与机构。将通过整合和扩展现有的临床数据来前瞻性地收集 临床数据库。与生物统计核心的交互将确保维护数据表的互操作性 在每个机构。 BMP 核心将提供访问世界一流的代谢组学和同位素中心的机会 在 WUSTL 进行追踪。经过验证的样品处理和保存方法，重点是优化 将提供代谢分析，以提高收集的所有生物样本的科学效用。一个 公开现有生物样本资源并评估任何请求的透明和公平的机制 供他们使用将被实施。因此，BMP 核心将补充现有的癌症中心资源 凭借专注的专业知识和努力来全面收集、注释、质量审查和分发 专门用于转化子宫内膜癌研究的生物样本。