LDL

低密度脂蛋白

• 批准号: 7953758
• 负责人: Henry J. Pownall
• 金额: $ 1.74万
• 依托单位: BAYLOR COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-12-01 至 2009-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7953758
• 关键词: Cholesterol; Cholesterol Esters; Cholesterol Homeostasis; Complex; Computer Retrieval of Information on Scientific Projects Database; Coronary Arteriosclerosis; Electron Microscopy; Endocytosis; Funding; Grant; Institution; LDL Cholesterol Lipoproteins; Ligands; Lipids; Low Density Lipoprotein Receptor; Low-Density Lipoproteins; Molecular; Phospholipids; Plasma; Research; Research Personnel; Resources; Risk Factors; Source; Structure; Surface; Triglycerides; United States National Institutes of Health; apolipoprotein B-100; base; interest; macromolecule; monolayer

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. An elevated plasma level of low density lipoprotein (LDL)-cholesterol is a major risk factor for atherosclerotic coronary artery disease (Gotto and Pownall, 1999). LDL comprises a neutral lipid core of cholesteryl esters (CEs) and triglycerides, surrounded by a surface monolayer of phospholipids, free cholesterol, and apolipopro-tein B-100 (apoB-100), which contains the ligand for the LDL-receptor (LDLR) that initiates LDL endocytosis, a key step in cholesterol metabolism. The molecular basis of LDL endocytosis would be better understood if we could determine the structure of the LDL/LDLR complex. We are interested in determining the cryo-EM structure of the LDL and LDLR complex.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 低密度脂蛋白（LDL） - 胆固醇的血浆水平升高是动脉粥样硬化冠状动脉疾病的主要危险因素（Gotto and Pownall，1999）。 LDL comprises a neutral lipid core of cholesteryl esters (CEs) and triglycerides, surrounded by a surface monolayer of phospholipids, free cholesterol, and apolipopro-tein B-100 (apoB-100), which contains the ligand for the LDL-receptor (LDLR) that initiates LDL endocytosis, a key step in cholesterol代谢。如果我们可以确定LDL/LDLR复合物的结构，则可以更好地理解LDL内吞作用的分子基础。我们有兴趣确定LDL和LDLR复合物的冷冻EM结构。