ASSESSMENT OF CHANGES IN RENAL CORTICAL AND MEDULLARY BLOOD FLOW BY CONTRAST U/S

通过对比 U/S 评估肾皮质和髓质血流量的变化

• 批准号: 7951469
• 负责人: KAMBIZ KALANTARI
• 金额: $ 1.17万
• 依托单位: UNIVERSITY OF VIRGINIA
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-03-01 至 2010-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7951469
• 关键词: Blood flow; Blood specimen; Clinical Research; Computer Retrieval of Information on Scientific Projects Database; Contrast Media; Coronary artery; Diagnosis; Diet; Funding; Grant; Hand; Hour; Image; Individual; Infusion procedures; Injection of therapeutic agent; Institution; Kidney; Measures; Medical; Methods; Microbubbles; Myocardium; Nephrology; Pilot Projects; Proteins; Radioactive; Renal Artery Stenosis; Renal Blood Flow; Research; Research Personnel; Resources; Source; Techniques; Technology; Time; Ultrasonography; United States National Institutes of Health; Urine; clinical practice; response

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Current techniques of measuring renal blood flow and GFR are time consuming and troublesome. They require either injection of a radioactive material or infusion of a substance for several hours with multiple urine and blood sampling. As a result, these methods are currently out of favor to use in clinical practice and are only reserved for research purposes. On the other hand, ultrasonography is a noninvasive and widely available technology with many uses in the field of nephrology. Recently the use of microbubbles as contrast agents to enhance ultrasound images has become popular in different medical fields. This technique is currently being utilized in imaging of the myocardium and coronary arteries. A few studies have demonstrated comparable accuracy of contrast enhanced ultrasound (CEU) to other conventional methods in diagnosing renal artery stenosis. In this pilot study, we will compare the accuracy of CEU in assessing the changes in renal blood flow in response to a high protein diet to the standard method using PAH clearance in healthy individuals. We will also evaluate the utility of CEU in assessing the changes in regional renal blood flow to cortex and medulla.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此，可以在其他清晰的条目中表示。列出的机构是 对于中心，这不一定是调查员的机构。 当前测量肾脏血流和GFR的技术耗时且麻烦。他们需要注射放射性材料或用多种尿液和血液采样的物质输注几个小时。结果，这些方法目前不可能用于临床实践，仅用于研究目的。另一方面，超声检查是一种无创和广泛可用的技术，在肾脏科领域具有许多用途。最近，将微泡作为对比剂增强超声图像的使用已在不同的医疗领域变得流行。目前，该技术用于心肌和冠状动脉的成像。一些研究表明，在诊断肾动脉狭窄的情况下，对比度增强超声（CEU）的对比度的准确性可比较。在这项试点研究中，我们将比较CEU在评估健康个体中使用PAH清除率的标准方法评估肾脏血流变化的准确性。 我们还将评估CEU在评估区域肾脏血液流向皮质和延髓的变化方面的效用。