URINE SCREEN OF TYPE 2 DM WITH AND WITHOUT NEPHROPATHY FOR INFLAMMATORY MARKERS

伴或不伴肾病的 2 型 DM 尿液筛查炎症标志物

• 批准号: 7951459
• 负责人: KAMBIZ KALANTARI
• 金额: $ 1.07万
• 依托单位: UNIVERSITY OF VIRGINIA
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-03-01 至 2010-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7951459
• 关键词: Cardiovascular Diseases; Cardiovascular system; Clinical Research; Computer Retrieval of Information on Scientific Projects Database; Development; Diabetes Mellitus; Diabetic Nephropathy; Diagnosis; Event; Funding; General Population; Goals; Grant; Individual; Inflammation; Institution; Kidney Diseases; Non-Insulin-Dependent Diabetes Mellitus; Patients; Pilot Projects; Population; Proteins; Research; Research Personnel; Resources; Source; United States National Institutes of Health; Urine; design; diabetic; high risk; inflammatory marker; tool

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. About six percent of the U.S. population or almost 17 million individuals are diagnosed with diabetes mellitus. Diabetic individuals have a higher rate of cardiovascular and kidney disease compared to the general population. Evidence has shown that inflammation may be a major factor for development of these conditions. The goal of this study is to compare levels of inflammatory markers in diabetics who have and who do not have higher than normal urine protein, a sign of diabetic kidney disease (diabetic nephropathy). Eligible patients are 18-70 years old with type II diabetes and signs of early kidney disease. The results of this pilot study will be used to design larger trials to examine the relationship between diabetic nephropathy and higher cardiovascular disease. These results could potentially provide tools to identify patients at higher risk for cardiovascular events or progression of kidney disease.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目和 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 对于中心来说，它不一定是研究者的机构。 大约 6% 的美国人口或近 1700 万人被诊断患有糖尿病。 与一般人群相比，糖尿病患者心血管和肾脏疾病的发病率更高。 有证据表明炎症可能是这些病症发生的主要因素。 本研究的目的是比较尿蛋白高于正常水平的糖尿病患者的炎症标志物水平，尿蛋白是糖尿病肾病（糖尿病肾病）的征兆。 符合资格的患者为 18-70 岁、患有 II 型糖尿病并有早期肾脏疾病迹象的患者。 这项试点研究的结果将用于设计更大规模的试验，以检查糖尿病肾病与高级心血管疾病之间的关系。这些结果可能提供工具来识别心血管事件或肾脏疾病进展风险较高的患者。