LUPRON DEPOT IN THE TREATMENT OF CENTRAL PRECOCIOUS PUBERTY

LUPRON Depot 治疗中枢性性早熟

• 批准号: 7951301
• 负责人: PETER A LEE
• 金额: $ 0.09万
• 依托单位: PENNSYLVANIA STATE UNIV HERSHEY MED CTR
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-04-01 至 2010-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7951301
• 关键词: Abdomen; Child; Clinical Research; Clinical Trials; Computer Retrieval of Information on Scientific Projects Database; Enantone; Female; Follow-Up Studies; Funding; Grant; Height; Institution; Leuprolide Acetate; Long-Term Effects; Measurement; Office Visits; Participant; Precocious Puberty; Questionnaires; Reproductive Health; Research; Research Personnel; Research Subjects; Resources; Source; Time; Ultrasonography; United States National Institutes of Health; Weight; research study

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Previous studies have indicated that leuprolide acetate (Lupron Depot) is efficacious in the treatment of precocious puberty. In the late 1990's Dr. Lee and research subjects at HMC participated in some of these clinical trials. The purpose the proposed research study is to determine the long-term effects of using Lupron in children with central precocious puberty. Approximately 50 people will take part in this research nationwide and about 9 subjects who were previously studied at HMC are expected to take part at this follow up study. Each subject will be asked to have one or two office visits in the GCRC, at which time the following assessments will be completed: height Measurement, weight Measurement, completion of a brief questionnaire that will ask about reproductive health, and an abdominal Ultrasound for female participants.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 先前的研究表明，乙酸亮脂（Lupron Depot）在治疗早熟青春期有效。在1990年代后期，HMC的Lee博士和研究对象参加了其中一些临床试验。 拟议的研究目的是确定在中央早熟青春期儿童中使用lupron的长期影响。 大约有50人将参加全国这项研究，大约有9名以前在HMC研究的受试者预计将参加此后续研究。 将要求每个受试者在GCRC中进行一次或两个办公室访问，此时将完成以下评估：高度测量，体重测量，完成一份简短的问卷调查表，该问卷将询问有关生殖健康的问题，以及女性参与者的腹部超声检查。