STRUCTURAL FUNCTIONAL RELATIONSHIPS IN DIABETIC NEPHROPATHY

糖尿病肾病的结构功能关系

• 批准号: 7951637
• 负责人: MICHAEL S MAUER
• 金额: $ 1.32万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-12-01 至 2009-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7951637
• 关键词: Clinical Research; Computer Retrieval of Information on Scientific Projects Database; Diabetic Nephropathy; Electrons; Funding; Grant; Hypertension; Institution; Lesion; Light; Microalbuminuria; Microscopic; Pancreas; Proteinuria; Protocols documentation; Research; Research Personnel; Resources; Source; Transplantation; United States National Institutes of Health; morphometry

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This protocol has two major purposes. First, we are examining structural-functional relationships in diabetic nephropathy using quantitative light and electron microscopic morphometry to determine the structural substrates for microalbuminuria, proteinuria, hypertension and declining GFR. Secondly, we are examining the effects of pancreas transplant on the established lesions of diabetic nephropathy at five, ten, and fifteen year intervals after successful transplantation.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此，可以在其他清晰的条目中表示。列出的机构是 对于中心，这不一定是调查员的机构。 该协议有两个主要目的。 首先，我们使用定量光和电子显微镜形态计检查了糖尿病性肾病中的结构功能关系，以确定微珠尿症，蛋白尿，高血压和GFR下降的微量珠尿症的结构底物。 其次，我们正在研究胰腺移植对成功移植后五年，十和15年间隔五年，十年和15年间胰腺移植对糖尿病性肾病的固定病变的影响。