TISSUE CORE

组织核心

• 批准号: 7944905
• 负责人: DANIEL J BRAT
• 金额: $ 17.02万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-04-07 至 2012-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7944905
• 关键词: Acceleration; Alcohols; Anatomy; Animal Model; Atlases; Biopsy Specimen; Cancer Center Support Grant; Categories; Clinical; Clinical trial protocol document; Collaborations; Communications Personnel; Consent; Contracts; Core Facility; Diagnostic; Epidemiologic Studies; Equipment; Equipment and supply inventories; Excision; Floor; Formalin; Freezing; Funding; Glioblastoma; Grant; Harvest; Health Services Research; Hospitals; Hour; Human; Human Resources; Image Analysis; Individual; Institutes; Investigation; Laboratories; Lasers; Liquid substance; Malignant Neoplasms; Medicine; Microscopy; Nitrogen; Operating Rooms; Operative Surgical Procedures; Pathologist; Pathology; Patient Care; Preparation; Process; Productivity; Protocols documentation; RNA; Research; Research Ethics Committees; Research Personnel; Research Support; Resource Sharing; Schedule; Science; Scientist; Services; Site; Solutions; Source; Specimen; Staining method; Stains; Support Groups; Surgical Pathology; Tissue Banking; Tissue Banks; Tissue Microarray; Tissue Procurements; Tissue Sample; Tissues; Training; Tumor Bank; University Hospitals; Work; base; cancer Biomedical Informatics Grid; cancer genome; experience; human disease; human tissue; member; programs; prospective; quality assurance; repository; success; tissue processing; tool; tumor

The Human Tissue and Pathology Core (Shared Resource Category 4.06) of the Winship Cancer Institute (WCI) will be critical to the overall clinical and scientific success by enhancing tissue-based investigation through its procurement and distribution of human cancer specimens and its comprehensive histopathologic services. The Core is highly integrated within the WCI, serving individual and team science projects in all of the major programs and interfacing directly with the other Cores. The tissue banking component of the Core consists of an IRB-approved Human Tissue Procurement Service (HTPS), located within the Emory University Hospital and the WCI, with affiliated banking sites at Grady Memorial and Crawford Long Hospitals. Tissue procurement personnel are highly experienced in anatomic pathology and tumor banking protocols, with quality assurance of specimens provided by members of the Department of Pathology. Tumor and normal control tissues, along with other biospecimens associated with specialized protocols, are procured as frozen, fresh, fixed, embedded or other specialized preparation, and inventoried in caTissue Core, a caBIG tool for biospecimen repositories. Tissues are distributed to WCI investigators with IRBapproved protocols to further the clinical, translational, basic and epidemiologic research. Pathology services of the Core are provided by the Research Pathology Laboratory, a full service lab located on the 5th floor of the WCI building with experienced personnel and equipment for tissue processing, histological and immunohistochemical staining and analysis, laser capture microscopy, tissue microarrays and high throughput, automated image analysis for immunofluorescent and bright field microscopy. This lab is capable of processing high volumes of tissue samples derived from human disease and animal models and works in close collaboration with the other Cores and scientific programs of the WCI as demonstrated by research productivity and support of group science grants. The success of this Core is also highlighted by its contract with the NCI for collecting and processing glioblastoma specimens for The Cancer Genome Atlas Project. Together, the HTPS and the Research Pathology Lab provide centralized, efficent and high quality services to WCI investigators for acceleration of scientific discovery.

Winship癌症研究所（WCI）的人体组织和病理学核心（共享资源4.06）通过通过其人类癌症标本及其全面的组织病理学服务来增强基于组织的研究，对整体临床和科学成功至关重要。核心高度集成在WCI中，为所有主要计划中的个人和团队科学项目提供服务，并直接与其他核心接触。核心的组织库组成部分由位于埃默里大学医院和WCI内的IRB批准的人体组织采购服务（HTPS）组成，格雷迪纪念馆和克劳福德·朗医院的隶属银行现场。组织采购人员在解剖病理和肿瘤库中经验丰富 协议，以及病理部成员提供的标本的质量保证。肿瘤和正常对照组织以及与专门方案相关的其他生物测量，以冷冻，新鲜，固定，嵌入式或其他专业制剂的形式获取，并在Catissue Core中库存，这是一种用于生物测量库的Cabig工具。将组织分配给WCI研究人员，该研究人员具有IRBARDED方案，以进一步进行临床，转化，基本和流行病学研究。核心的病理服务由研究病理实验室提供，这是一个完整的服务实验室，位于WCI建筑物的5楼，带有经验丰富的人员和设备，用于组织处理，组织学和免疫组织化学染色和分析，激光捕获显微镜，组织微观阵列以及高度 用于免疫荧光和明亮场显微镜的吞吐量，自动图像分析。该实验室能够处理源自人类疾病和动物模型的大量组织样本，并与WCI的其他核心和科学计划密切合作，这是研究生产力和团体科学补助金的支持所证明的。与NCI的合同为癌症基因组图集项目收集和加工胶质母细胞瘤标本也强调了该核心的成功。 HTP和研究病理学实验室共同为WCI研究人员提供了集中，有效和高质量的服务，以加速科学发现。