CANCER GENETICS AND EPIGENETICS

癌症遗传学和表观遗传学

基本信息

批准号：
7944873
负责人：
Paul William Doetsch
金额：
$ 7.98万
依托单位：
EMORY UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
起止时间：
2009-04-07 至 2012-03-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7944873
关键词：
Accounting Address Allelic Imbalance Antineoplastic Agents Architecture Area Basic Science Behavioral Biochemical Biological Markers Biological Models Cancer Center Support Grant Chromatin Chromosomal Instability Chromosome abnormality Collaborations Computer Simulation DNA DNA Damage DNA Modification Process DNA Repair Development Epigenetic Process Event Funding Gene Expression Gene Mutation Genetic Genome Genomic Instability Human Institutes Investigation Maintenance Malignant Neoplasms Molecular Mutagenesis Nuclear Nucleic Acids Publications Publishing Suppressor Genes Tumor Suppressor Genes antitumor agent cancer cell cancer diagnosis cancer genetics chromatin modification chromatin remodeling college drug development functional genomics genetic variant medical schools member novel outcome forecast programs response tumor tumorigenesis

项目摘要

Program 1. Cancer Genetics and Epigenetics (CGE): DNA damage, genetic mutations, genomic instability and alterations in DNA/chromatin modifications that modify gene expression are all critical events that contribute to the development of cancers in humans. The primary themes of the CGE Program reflect a major emphasis on basic science investigations directly related to oncogenesis. The CGE Program's four main thematic areas are: (1) DNA damage, repair, mutagenesis and genetic instability; (2) epigenetics, including DNA and chromatin modification and chromatin remodeling; (3) chromosome instability and nuclear architecture; (4) cancer genetics and functional genomics. The aims of the CGE Program are: (1) To elucidate the underlying molecular and biochemical mechanisms that result in the establishment and maintenance of genetic instability during tumor development and progression. (2) To elucidate and understand how epigenetic modifications of DNA and chromatin structural components impact gene expression programs and other nucleic acid transactions during tumorigenesis. (3) To understand the mechanisms underlying chromosomal aberrations, allelic imbalances and alterations in nuclear architecture and their contributions to multi-step tumorigenesis. (4) To identify and characterize novel oncogenes and tumor suppressor genes and to develop genome-scale discovery and analysis platforms and computational models to identify genetic loci and genetic variants involved in tumorigenesis. The CGE Program is comprised of 26 members from 10 departments within the School of Medicine and Emory College. Currently, there are 24 funded program members with total support of approximately $9 million per year, of which NCI funding represents $3.9M ($2.6M direct). From 2003-2008 the CGE program members published 400 articles. Of these total publications, 39 (9.75%) are intraprogrammatic collaborations and 82 (20.5%) are interprogrammatic collaborations. From 2006-2008, CGE members published 183 articles. Intraprogrammatic collaborations account for 21 (11.5 %) and interprogrammatic collaborations account for 39 (21.3 %) of these publications.

项目 1. 癌症遗传学和表观遗传学 (CGE)：DNA 损伤、基因突变、基因组影响基因表达的 DNA/染色质修饰的不稳定性和改变都是关键事件有助于人类癌症的发展。 CGE 计划的主要主题反映了主要强调与肿瘤发生直接相关的基础科学研究。 CGE 计划的四个主要专题领域有：（1）DNA损伤、修复、突变和遗传不稳定性；（2）表观遗传学，包括DNA和染色质修饰以及染色质重塑； (3)染色体不稳定性与核建筑学; (4)癌症遗传学和功能基因组学。 CGE 计划的目标是： (1) 阐明导致建立和建立的潜在分子和生化机制在肿瘤发生和进展过程中维持遗传不稳定性。 (2) 阐明并了解 DNA 和染色质结构成分的表观遗传修饰如何影响基因肿瘤发生过程中的表达程序和其他核酸交易。 (3) 理解染色体畸变、等位基因失衡和核结构改变的潜在机制及其对多步骤肿瘤发生的贡献。 (4) 识别和表征新的癌基因肿瘤抑制基因并开发基因组规模的发现和分析平台以及计算模型来识别与肿瘤发生有关的遗传位点和遗传变异。 CGE 计划是由来自医学院和埃默里学院 10 个系的 26 名成员组成。目前，有 24 个受资助的计划成员，每年的支持总额约为 900 万美元，其中其中 NCI 资助金额为 390 万美元（直接资助金额为 260 万美元）。 2003-2008 年，CGE 计划成员发布了 400 篇文章。在这些出版物总数中，39 篇 (9.75%) 是项目内合作，82 篇 (20.5%) 是计划间合作。 2006年至2008年，CGE成员发表了183篇文章。项目内合作占 21 个（11.5%），项目间合作占其中 39 种（21.3%）出版物。