Biospecimens/Patient Registry Core

生物样本/患者登记核心

• 批准号: 7727452
• 负责人: Debra Bell
• 金额: $ 20.56万
• 依托单位: MAYO CLINIC ROCHESTER
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-07-01 至 2014-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7727452
• 关键词: Archives; Biostatistics Core; Blood; Cancer Center; Cancer Patient; Carcinoma; Cells; Classification; Clinic; Clinical; Collection; Communities; Confidentiality of Patient Information; Consent; Coupled; DNA; Data; Detection; Freezing; Future; Goals; Human; Immunohistochemistry; In Situ Hybridization; Instruction; Laboratories; Link; Malignant Neoplasms; Malignant neoplasm of ovary; Mayo Clinic Cancer Center; Medical Records; Molecular Analysis; Operative Surgical Procedures; Ovarian; Paraffin Embedding; Patients; Peritoneal; Process; Records; Reproduction spores; Research; Research Project Grants; Research Support; Resource Sharing; Resources; Services; Site; Slide; Specimen; Tissue Banks; Tissue Microarray; Tissues; Woman; Writing; anticancer research; base; blood product; data management; design; digital imaging; improved; patient registry; programs; sound; tissue registry

The goal of the Biospecimens and Patient Registry Core is to provide invesfigators in the Ovarian SPORE high quality pafient data, DNA, RNA, blood products, and cancer fissues from consented pafients with ovarian or primary peritoneal carcinoma and to make these resources available for future studies. The acfivifies of the Core will be conducted in a way that does not compromise patient confidentiality, yet will be as comprehensive as possible in the materials and data that are provided. The acquisifion of human fissue and subsequent cellular/molecular analysis of that fissue coupled with pafient data, maintaining strict confidenfiality, are key to many laboratory-based studies of cancer. The Mayo Clinic has a strong tradition of ethically sound support of research that links fissue acquisifion and patient data records. Paraffin embedded tissues, histological slides, and associated patient charts from surgeries performed since the first decade of the 1900's are maintained in Mayo's Tissue Registry and the Mayo Archives. Today, the Tissue and Cell Molecular Analysis (TACMA) Shared Resource of the Mayo Clinic Cancer Center is a resource of expertise, collaborafive support, and service for immunohistochemistry, in situ hybridization, tissue microarray construction, and digital imaging. Similarly, the Biospecimens Accessioning and Processing (BAP) Shared Resource is the primary site of accessioning and standardized processing of blood and frozen fissue collected explicitly for research from all three Mayo sites. This Core will be integrated with these existing fissue-oriented Cancer Center shared resources and other scientific Cores of this SPORE to provide 1) a coordinated, centralized, dedicated program for standardized collection, accessioning, processing, morphogenlc classification and evaluafion of biospecimens and 2) pafient data from fully consented ovarian cancer patients. The Core will be closely coordinated with the Biostatistics Core to provide seamless linkage of clinical annotation with research specimens for data management and analyses. Furthermore, under the direcfion of the Administrafion Executive committee and Core, the Biospecimens and Patient Registry Core will make biospecimens collected for this SPORE available to the ovarian cancer research community in order to sfimulate translafional research with the goal of reducing the burden of ovarian cancer. RELEVANCE (See Instructions): Biospecimens (tissues and blood) from ovarian cancer pafients and women without cancer are used in research projects designed to improve the detection and treatment of ovarian cancer. This Core supports the collection of these tissues and informafion from the medical record from women who give their written consent to donate these materials for research.

生物样本和患者登记核心的目标是为卵巢孢子的研究人员提供帮助 来自同意的患者的高质量患者数据、DNA、RNA、血液制品和癌症组织 卵巢癌或原发性腹膜癌，并使这些资源可用于未来的研究。这 核心的活动将以不损害患者机密的方式进行，但将 所提供的材料和数据尽可能全面。人体组织的获取 以及随后对该组织的细胞/分子分析以及患者数据，保持严格 保密性是许多基于实验室的癌症研究的关键。梅奥诊所有着悠久的传统 对将组织采集和患者数据记录联系起来的研究提供道德上合理的支持。石蜡包埋 自第一个十年以来进行的手术的组织、组织学幻灯片和相关患者图表 1900 年代保存在梅奥的组织登记处和梅奥档案馆中。今天，组织和细胞 梅奥诊所癌症中心的分子分析 (TACMA) 共享资源是专业知识资源， 免疫组织化学、原位杂交、组织微阵列的协作支持和服务 建筑和数字成像。同样，生物样本登记和处理 (BAP) 共享 资源是血液和冷冻组织加入和标准化处理的主要场所 从所有三个梅奥站点明确收集用于研究。该核心将与这些现有的集成 面向组织的癌症中心共享此 SPORE 的资源和其他科学核心，以提供 1) 协调、集中、专门的标准化收集、登记、处理程序， 生物样本的形态发生分类和评估以及 2) 来自完全同意的卵巢的患者数据 癌症患者。该核心将与生物统计核心密切配合，提供无缝衔接 对研究样本进行临床注释以进行数据管理和分析。此外，根据 管理执行委员会和核心、生物样本和患者登记核心的指导 将为该孢子收集的生物样本提供给卵巢癌研究界 以促进转化研究，以减轻卵巢癌的负担。 相关性（参见说明）： 来自卵巢癌患者和未患癌症的女性的生物样本（组织和血液）用于 旨在改善卵巢癌的检测和治疗的研究项目。该核心支持 从妇女的病历中收集这些组织和信息，并提供书面证明 同意捐赠这些材料用于研究。