Informatics Center for Neurogenetics and Neurogenomics

神经遗传学和神经基因组学信息学中心

基本信息

批准号：
7908172
负责人：
NELSON B. FREIMER
金额：
$ 76.92万
依托单位：
UNIVERSITY OF CALIFORNIA LOS ANGELES
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
起止时间：
2009-08-01 至 2014-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7908172
关键词：
Abbreviations Affinity Amyotrophic Lateral Sclerosis Area Arts Attention deficit hyperactivity disorder Award BAC (bacterial artificial chromosome)Behavior Bioinformatics Biomedical Research Biostatistics Core Biotechnology Brain Brain Diseases Classification Clinical Collaborations Communities Computer Analysis Computer software Consultations DNA Methyltransferase DNA Modification Methylases Data Data Analyses Databases Disease Education Epigenetic Process Face Faculty Funding Gene Expression Genes Genetic Genome Genomics Genotype Gilles de la Tourette syndrome Goals Hand Haplotypes Human Human Genome Huntington Disease Individual Informatics Inherited Institutes Internet Investigation Laboratories Letters Mammals Methods Mus National Institute of Neurological Disorders and Stroke Nervous system structure Neuraxis Neurosciences Neurosciences Research Pathway Analysis Phenotype Population Proteins Proteome Quantitative Trait Loci Research Research Institute Research Personnel Research Training Resource Sharing Resources Running Science Scientist Sequence Analysis Services Single Nucleotide Polymorphism Software Tools Technology Training Training Programs Translational Research United States National Institutes of Health Update Variant Weight cationic antimicrobial protein CAP 37 chromatin immunoprecipitation computerized tools computing resources cost digital experience genetic epidemiology genome wide association study instrumentation interest member neurobehavioral neurogenetics neuropsychiatry new technology next generation phenomics programs research study response tool translational neuroscience user-friendly

项目摘要

This is a proposal for an NINDS Institutional Center Core, the Informatics Center for Neurogenetics and Neurogenomics (ICNN) at UCLA. As with other areas of biomedical science, the post-genome era raises the prospect of transformational advances in neuroscience research. Neuroscience faces special challenges, however, in analysis, interpretation, and management of the vast quantities of information generated by genetic and genomic technologies. The phenotypic and organizational complexity of the nervous system calls for distinct analytical and informatics strategies and expertise. The ICNN will provide advanced analysis and informatics support to a highly interactive user group consisting of neuroscientists at UCLA, who are conducting basic, clinical, and translational research. These investigators have access to excellent facilities for genetics and genomics experimentation; the lack of corresponding resources in analysis and informatics constitutes a bottleneck in their research. ICNN faculty experts in statistical genetics, gene expression analysis, and bioinformatics will oversee the activities of highly-trained staff members who will accomplish three goals: 1) Providing expert consultation and analyses for neurogenetics and neurogenomics projects; 2) Developing and maintaining a shared computing resource that will include a computational cluster for computation-intensive analyses, web-servers and state of the art software tools for a wide range of applications (including user-friendly versions of public databases, as well as workstations on which ICNN users will be trained to employ these tools; 3) Providing hands-on training in analysis and informatics to the users.

这是Ninds机构中心核心，神经遗传学信息中心和 UCLA的神经基因组学（ICNN）。与生物医学科学的其他领域一样，基因组时代提高了神经科学研究的变革前景。神经科学面临特殊挑战，但是，在分析，解释和管理中生成的大量信息通过遗传和基因组技术。神经系统的表型和组织复杂性需要独特的分析和信息学策略和专业知识。 ICNN将提供高级分析以及对由UCLA的神经科学家组成的高度交互式用户组的信息学支持，进行基本，临床和转化研究。这些调查人员可以使用出色的设施用于遗传学和基因组学实验；分析和信息学缺乏相应的资源他们的研究构成了瓶颈。 ICNN统计遗传学，基因表达专家分析，生物信息学将监督训练有素的工作人员的活动三个目标：1）为神经遗传学和神经基因组学项目提供专家咨询和分析； 2）开发和维护共享计算资源，该资源将包括一个计算集群计算密集型分析，网络服务器和最先进的软件工具，用于广泛应用程序（包括用户友好版本的公共数据库，以及ICNN的工作站用户将接受培训以使用这些工具； 3）为分析和信息学提供动手培训用户。