P30 Center in Craniofacial Bone Biology

P30 颅面骨生物学中心

• 批准号: 7860961
• 负责人: Nicola C Partridge
• 金额: $ 74.69万
• 依托单位: NEW YORK UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-17 至 2011-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7860961
• 关键词: Accidents; Area; Award; Basic Science; Biocompatible Materials; Biology; Bone Matrix; Cancer Etiology; Cancer Grant Supplements (P30); Cartilage; Cleft Palate; Clinical; Complement; Dentistry; Disease; Electromagnetics; Faculty; Funding; Genetic Transcription; Goals; Growth; Injury; Lead; Leadership; Letters; Matrix Metalloproteinases; Mentors; New York; Oral Pathology; Orthodontics; Osteoblasts; Osteoclasts; Osteocytes; Parathyroid Hormones; Pediatric Dentistry; Positioning Attribute; Process; Prosthodontic specialty; Recruitment Activity; Regenerative Medicine; Research; Research Personnel; Scientist; Senior Scientist; Techniques; Time; Universities; Wages; War; Work; biomineralization; bone; chemokine; college; craniofacial; experience; human PTH protein; member; osteoblast differentiation; public health relevance; ranpirnase; repaired; skills

DESCRIPTION (provided by applicant): This is a P30 application to establish a Center in Craniofacial Bone Biology at New York University College of Dentistry (NYUCD). The PI, Dr. Nicola C. Partridge, has just been recruited as the new Chair of Basic Science and Craniofacial Biology at NYUCD with the agenda of consolidating and expanding Bone Biology at NYUCD. She is an internationally renowned, established bone biologist. A number of existing faculty members at the College of Dentistry have a significant focus on bone and cartilage growth, biomineralization and biomaterials. Dr. Partridge brings tremendous experience and stature in a number of areas of bone biology such as osteoblast differentiation, matrix metalloproteinases, parathyroid hormone action, transcription, electromagnetic stimulation of osteoblasts, chemokines and osteoclasts, as well as administrative and mentoring skills, which will pull the group together into a cohesive entity. Together with the existing faculty, Dr. Partridge will recruit two new junior basic science faculty in bone biology. They will be recruited in osteoclast biology, and osteocytes and their interaction with bone matrix to complement Dr. Partridge's and the existing faculty members' areas of research. The new junior faculty will have at least 75% of their time dedicated to research. The funds of the P30 grant will be used to support this effort for two years and provide partial support for their start-up packages. The College of Dentistry will provide the remainder of their salaries and start-up funds during the period of the award and continue to support the faculty with total salary support and the remainder of their start-up packages for at least two additional years after the termination of the P30. The recruitment of Dr. Partridge and two junior faculty will permit the establishment of a strong interdisciplinary Craniofacial Bone Biology Center at NYUCD. PUBLIC HEALTH RELEVANCE: This is a P30 application to establish a Center in Craniofacial Bone Biology at New York University College of Dentistry (NYUCD). This will advance research into understanding important disease processes such as cleft palate and lead to strategies for the repair of such problems along with Craniofacial injuries caused by cancer, accident and war using regenerative medicine techniques.

描述（由申请人提供）：这是P30申请，旨在在纽约大学牙科学院（NYUCD）建立颅面骨生物学中心。 PI，Nicola C. Partridge博士刚刚被招募为Nyucd的基础科学和颅面生物学的新主席，并在NYUCD合并和扩大骨骼生物学的议程。她是一位国际知名的骨生物学家。牙科学院的许多现有教职员工都非常关注骨骼和软骨生长，生物矿化和生物材料。 Partridge博士在许多骨骼生物学领域（例如成骨细胞差异化，基质金属蛋白酶，甲状旁腺激素的作用，转录，电磁刺激骨细胞，趋化因子，趋化因子和骨质塑料以及将组合的能力）组合成组合成组合的许多领域都带来了丰富的经验和地位。 Partridge博士与现有的教师一起招募了两位新的骨骼生物学基础科学教师。它们将在破骨细胞生物学和骨细胞中招募，以及与骨基质的相互作用，以补充Partridge博士和现有教职员工的研究领域。新的初级教师将至少有75％的时间致力于研究。 P30赠款的资金将用于两年来支持这项工作，并为其启动套餐提供部分支持。牙科学院将在奖励期间提供其余的薪水和初创企业资金，并继续在P30终止后至少两年内以全部薪水支持以及其余的启动套餐来支持该教职员工。招募Partridge博士和两个初级教师将允许在Nyucd建立一个强大的跨学科颅骨生物学中心。 公共卫生相关性：这是P30申请，旨在在纽约大学牙科学院（NYUCD）建立颅面骨生物学中心。这将进一步研究了解重要的疾病过程，例如left裂，并导致修复此类问题的策略以及使用再生医学技术由癌症，事故和战争造成的颅面损伤。