Supporting New Faculty Recruitment Through BioMedical Research Core Center

通过生物医学研究核心中心支持新教师招聘

• 批准号: 7860816
• 负责人: David H Ingbar
• 金额: $ 57.83万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-30 至 2011-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7860816
• 关键词: Agmatine; Area; Basic Science; Biomedical Research; Clinical; Clinical Trials; Communicable Diseases; Complement; Critical Care; Cystic Fibrosis; Dimensions; Disease; Doctor of Philosophy; Environment; Faculty; Fellowship; Funding; Grant; Growth; Haemophilus Infections; Health; Health Sciences; Home environment; Hypersensitivity; Individual; Infection; Injury; Lung; Lung Inflammation; Medicine; Mentorship; Microbial Biofilms; Microbiology; Minnesota; Pathogenesis; Pediatrics; Physicians; Polyamines; Postdoctoral Fellow; Pseudomonas Infections; Public Health; Recruitment Activity; Research; Respiratory Tract Infections; Role; Scientist; Sleep; Students; Training; Translational Research; Universities; career; career development; catalyst; clinical care; cystic fibrosis patients; injury and repair; innovation; interest; lung injury; medical schools; meetings; member; microbial; pathogen; programs; ranpirnase; success

DESCRIPTION (provided by applicant): The University of Minnesota Pulmonary, Allergy, Critical Care & Sleep (PACCS) Division has been systematically recruiting additional physician scientists focused on lung injury and repair to join the tenure track faculty. Our faculty met and identified a significant gap in our faculty research interest profile in this area - respiratory infections. This area is not only of great importance as a public health issue in the US and worldwide, it is also an area with outstanding multi-disciplinary, collaborative scientific opportunities at the University of Minnesota. Within the PACCS Division, among our NIH-funded PIs, there are 7 faculty with expertise in lung inflammation and injury. In addition, there are three academically strong Centers and programs pertinent to our proposed recruit, providing a dynamic research environment to promote scientific growth and career development. The Center for Infectious Disease, Microbiology & Translational Research brings together faculty from the Medicine, Pediatrics and Microbiology Departments in interdisciplinary translational research on microbial pathogenesis. The Center for Lung Science and Health provides a home for faculty and students from across the Academic Health Center and larger University with interests related to lung health and disease. Finally, the University of Minnesota has an internationally renowned Cystic Fibrosis program. While this program is outstanding in clinical care and clinical trials activity, the basic research component is less strong. Thus a major recruitment target area of the PACCS Division is for a physician-scientist with research focused on respiratory infections, particularly with relevance to lung injury in Cystic Fibrosis. Our proposed P30 recruit, Bryan Williams MD, PhD is completing his fourth year of Pulmonary, Critical Care & CF fellowship at Vanderbilt University. His research focus is on host-pathogen interactions in respiratory infections, specifically exploring the role of a polyamine precursor, agmatine, that is important in Pseudomonas infections and in biofilm formation. He obtained his Microbiology PhD under the mentorship of Dr. Arnie Smith studying Hemophilus infections and his post-doctoral fellowship research has been supervised by Dr. Timothy Blackwell. Dr Williams' research relates directly to his clinical interest in CF-related lung dise disease, enabling convergence of his research and clinical program. The recruitment of Bryan Willliams MD, PhD will add the new dimension of expertise in respiratory infections to the PACCS Divisional research It will greatly augment basic research in the Cystic Fibrosis Center program and will provide a research bridge between the Center for Lung Science and Health and the Center for Infectious Disease, Microbiology Translational Research. Dr Williams's research brings an innovative approach to understanding and decreasing Pseudomonas infection in CF patients.

描述（由申请人提供）：明尼苏达大学肺、过敏、重症监护和睡眠 (PACCS) 部门一直在系统地招募更多专注于肺损伤和修复的医师科学家加入终身教授职位。我们的教职人员会面并发现了我们教职人员在这一领域的研究兴趣中的一个重大差距——呼吸道感染。该领域不仅作为美国和世界范围内的公共卫生问题具有重要意义，而且也是明尼苏达大学拥有出色的多学科合作科学机会的领域。在 PACCS 部门内，在 NIH 资助的 PI 中，有 7 名教师在肺部炎症和损伤方面具有专业知识。此外，还有与我们拟招募的人员相关的三个学术实力雄厚的中心和项目，提供了一个充满活力的研究环境，以促进科学成长和职业发展。传染病、微生物学和转化研究中心汇集了来自医学、儿科和微生物学系的教师，从事微生物发病机制的跨学科转化研究。肺部科学与健康中心为来自学术健康中心和更大的大学对肺部健康和疾病感兴趣的教师和学生提供了一个家。最后，明尼苏达大学拥有国际知名的囊性纤维化项目。虽然该项目在临床护理和临床试验活动方面表现出色，但基础研究部分不太强大。因此，PACCS 部门的一个主要招聘目标领域是专注于呼吸道感染研究的医师科学家，特别是与囊性纤维化肺损伤相关的研究。我们提议的 P30 招募人员 Bryan Williams MD、PhD 即将在范德比尔特大学完成他第四年的肺科、重症监护和 CF 奖学金。他的研究重点是呼吸道感染中宿主与病原体的相互作用，特别是探索多胺前体胍丁胺的作用，它在假单胞菌感染和生物膜形成中非常重要。他在研究嗜血杆菌感染的 Arnie Smith 博士的指导下获得了微生物学博士学位，他的博士后研究由 Timothy Blackwell 博士指导。 Williams 博士的研究与他对 CF 相关肺疾病的临床兴趣直接相关，从而使他的研究和临床计划得以融合。 招募 Bryan Willliams 医学博士、博士将为 PACCS 部门研究增添呼吸道感染专业知识的新维度，这将大大增强囊性纤维化中心项目的基础研究，并将在肺科学与健康中心和肺科学与健康中心之间架起一座研究桥梁。传染病微生物学转化研究中心。 Williams 博士的研究为了解和减少 CF 患者的假单胞菌感染提供了一种创新方法。