NATIONAL CHILDREN'S STUDY

国家儿童研究中心

• 批准号: 7946664
• 负责人: BARBARA ENTWISLE
• 金额: $ 36.01万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-09-26 至 2013-09-25
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7946664
• 关键词: NATIONAL; CHILDREN; STUDY

The National Children's Study (NCS) is prospective longitudinal cohort study of the individual and combined effects of environmental exposures and gene environmental interactions on child health and development in a representative sample of approximately 100,000 children born in the United States. The children will be followed from before birth until age 21. The importance and timeliness of this study are based on many factors, including past experiences demonstrating profound effects of environmental exposures, such as exposures to alcohol during pregnancy and to lead in early childhood on child health and development; the special vulnerabilities of children to environmental exposures compared to adults; known ongoing exposures, such as prevalent levels of non-persistent pesticides or hours of media exposure per day in young children; and evidence for environmental contributions or causes to such high-impact conditions as autism, developmental delay and developmental disability, asthma, and obesity. The primary aim of the NCS is to investigate the separate and combined effects of environmental exposures (chemical, biological, physical, psychosocial) as well as gene-environment interactions on pregnancy outcomes, child health and development, and precursors of adult disease. Unique features of the study include its focus on environmental exposures at the earliest stages of pregnancy (as well as thereafter) and the breadth of planned exposure and outcome measurements. The NCS responds to the Congressional mandate of the Children's Health Act of 2000, that the NICHD and a consortium of federal agencies plan and conduct a longitudinal study of the impacts of environmental exposures on children. The NCS will employ a national probability sampling approach to select locations and participants for conduct of the study. The sampling design utilizes a multistage clustered approach. In the first stage, 105 locations (generally corresponding to single counties) were randomly selected from all U.S. counties. Seven of the locations serve as the initial or Vanguard Locations, participating in the pilot phase of the NCS. Because the focus of the study includes assessment of the impact of exposures that occur early in pregnancy, both pregnant women and their partners, and women of childbearing age, comprise the initial target population for enrollment. Data will be collected in combinations of face-to-face contacts and remote collection methods, e.g., telephone, computer, or mail-in questionnaires. The expected frequency of contact (face-to-face or remote) is approximately every three months through age one, every six months through age five years and annually thereafter. For a sample of children enrolled in the study, visits will also be made to child care and school settings for collection of environmental samples and observational data. Anticipated biologic specimens include blood, urine, hair, and nail clippings from mothers and children; blood, urine, and hair from fathers; cord blood, umbilical cord and placental tissues, and meconium collected at/around the time of delivery; vaginal swabs, and breast milk from mothers. Anticipated environmental samples include air, dust, soil, food, and water. .

国家儿童研究（NCS）是对个人暴露和基因环境相互作用对儿童健康和发育的个人纵向人群研究的前瞻性纵向人群研究。孩子将从出生前到21岁。这项研究的重要性和及时性是基于许多因素，包括过去的经验，表现出对环境暴露的深远影响，例如怀孕期间对酒精的暴露以及在幼儿对儿童健康和发育的领导；与成年人相比，儿童在环境暴露中的特殊脆弱性；已知的正在进行的暴露量，例如普遍的非持久农药或幼儿每天的媒体暴露水平；以及对自闭症，发育延迟和发育障碍，哮喘和肥胖等高影响状况的环境贡献或原因的证据。 NCS的主要目的是研究环境暴露（化学，生物学，身体，心理社会）的独立和综合作用，以及基因环境相互作用对妊娠结局，儿童健康和发育以及成人疾病的前体的相互作用。该研究的独特特征包括在怀孕的最早阶段（以及此后）的关注环境暴露以及计划的暴露和结果测量的广度。 NCS对2000年《儿童健康法》的国会任务做出了回应，即联邦机构的NICHD和联盟计划，并对环境暴露对儿童的影响进行纵向研究。 NCS将采用国家概率抽样方法来选择研究地点和参与者进行研究。采样设计采用了多阶段聚类方法。在第一阶段，从美国所有县随机选择了105个地点（通常与单个县相对应）。其中七个位置是NCS的试点阶段的初始或先锋位置。因为该研究的重点包括评估孕妇及其伴侣的孕妇早期暴露的影响以及育龄的妇女，包括最初的入学目标人群。数据将与面对面联系人和远程收集方法的组合（例如电话，计算机或邮寄问卷）收集。预期的接触频率（面对面或远程）大约每三个月到一个月，每六个月至五岁，然后每年每年一次。对于参加研究的儿童样本，还将访问儿童保育和学校环境，以收集环境样本和观察数据。预期的生物标本包括来自母亲和儿童的血液，尿液，头发和指甲剪报；父亲的血液，尿液和头发；脐带血，脐带和胎盘组织以及分娩时/分娩时收集的胎粪；阴道拭子和母亲的母乳。预期的环境样品包括空气，灰尘，土壤，食物和水。 。