Cognitive and behavioral consequences of focal brain lesions acquired during deve

开发过程中获得的局灶性脑损伤的认知和行为后果

基本信息

批准号：
7885278
负责人：
Steven W Anderson
金额：
$ 11.09万
依托单位：
UNIVERSITY OF SOUTHERN CALIFORNIA
依托单位国家：
美国
项目类别：
财政年份：
资助国家：
美国
起止时间：
至
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/7885278
关键词：
3-Dimensional Academic achievement Accounting Address Adult Age Anxiety Disorders Aphasia Area Behavior Behavioral Brain Brain Injuries Brain region Child Childhood Childhood Injury Chronic Cognition Cognitive Complex Conduct Disorder Data Development Diagnosis Diffusion Disease Distant Emotional Emotions Employment Enrollment Evaluation Focal Brain Injuries Functional Imaging Functional disorder Funding Gray unit of radiation dose Human Development Imaging Techniques Impairment Individual Injury Laboratories Language Development Left Lesion Life Location Longitudinal Studies Magnetic Resonance Imaging Measurement Measures Medial Mental disorders Methods Monitor Neurologic Outcome Participant Patient Self-Report Patients Perception Protocols documentation Psychopathology Psychophysiology Public Health Recovery of Function Registries Regulation Reporting Research Research Design Resources Sampling Series Site Social Adjustment Social Behavior Social Functioning Source Stimulus Structure System Telencephalon Temporal Lobe Testing Thick Underrepresented Minority Weight base brain behavior developmental disease diffusion anisotropy early onset focal brain damage follow-up functional outcomes gray matter hemisphere damage indexing morphometry neurobehavioral disorder neuroimaging neuropsychological patient registry psychosocial public health relevance reconstruction relating to nervous system response social social skills white matter

项目摘要

PROJECT 3: CONSEQUENCES OF FOCAL BRAIN LESIONS ACQUIRED DURING DEVELOPMENT Lesion method studies of individuals who have sustained childhood-onset focal brain damage are an important means of gathering more precise descriptions of brain-behavior relationships in developmental disorders. Conditions causing focal brain damage in childhood are not common, but we have developed effective mechanisms of enrolling a sufficient number of patients for systemic studies. During the current funding period we have established a registry of patients with early-onset focal brain damage, and have collected comprehensive neuropsychological data characterizing their cognition, emotion, and psychosocial functioning. Here we propose to conduct a series of hypothesis-driven studies designed to further delineate the neuropsychological and neuroanatomical factors that contribute to the chronic impairments of cognition, emotion, and social behavior that characterize some patients with childhood-onset brain damage. We will continue the longitudinal study of the patients in the registry, as well as newly enrolled patients, using: (1) precise description of brain lesions using MRI and 3-D reconstruction, (2) comprehensive characterization of cognition and behavior with standardized, age-appropriate neuropsychological measures, (3) standardized indices of functional outcome (academic achievement, employment, social adjustment), (4) experimental measures of cognition and behavior, with a focus on emotion and social competence, and (5) analysis of gray and white matter structure in brain regions functionally associated with the damaged area. Delineation of relationships between damage to specific neural systems early in life and the short- and long-term consequences for cognition, emotion, and behavior is providing fundamental information of relevance to the understanding of human development and of importance for better evaluation and treatment of neurobehavioral disorders with onset in childhood. Public health relevance: Developmental disorders of cognition, emotion, and social behavior present a major public health burden, but their underlying brain mechanisms remain poorly understood. This research provides a unique and important source of information regarding the neural bases of cognition, emotion, and their interaction during development.

项目 3：发育过程中发生的局灶性脑损伤的后果对患有儿童期局灶性脑损伤的个体进行损伤方法研究是一项收集更精确的发育过程中大脑行为关系描述的重要手段失调。导致儿童局灶性脑损伤的疾病并不常见，但我们已经开发出招募足够数量的患者进行系统研究的有效机制。当前期间在资助期间，我们建立了早发性局灶性脑损伤患者的登记册，并已收集了全面的神经心理学数据，描述了他们的认知、情感和社会心理发挥作用。在这里，我们建议进行一系列假设驱动的研究，旨在进一步描述导致慢性认知障碍的神经心理学和神经解剖学因素，情绪和社会行为是一些儿童期脑损伤患者的特征。我们将继续对登记中的患者以及新入组的患者进行纵向研究，使用：（1）使用 MRI 和 3D 重建精确描述脑部病变，(2) 全面表征通过标准化、适合年龄的神经心理学测量来评估认知和行为，(3) 标准化功能结果指数（学业成绩、就业、社会适应），（4）实验性认知和行为的测量，重点是情感和社交能力，以及（5）分析与受损区域功能相关的大脑区域的灰质和白质结构。描绘生命早期特定神经系统损伤与短期和长期损伤之间的关系对认知、情感和行为的影响提供了与事物相关的基本信息了解人类发展以及更好地评估和治疗疾病的重要性儿童期发病的神经行为障碍。公共卫生相关性：认知、情感和社会行为的发育障碍是一个主要的公共卫生负担，但其潜在的大脑机制仍知之甚少。这项研究提供了关于认知、情感和认知的神经基础的独特而重要的信息来源。他们在开发过程中的相互作用。