Corticostriatal-hypothalamic circuitry and food reward
皮质纹状体-下丘脑回路和食物奖励
基本信息
- 批准号:7194345
- 负责人:
- 金额:$ 24.14万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:1990
- 资助国家:美国
- 起止时间:1990-08-01 至 2009-02-28
- 项目状态:已结题
- 来源:
- 关键词:AMPA ReceptorsAddressAdultAffectiveAmino AcidsAmygdaloid structureAnimal FeedAppetitive BehaviorAreaAttentionBehavior ControlBehavioralBiologicalBrainBrain StemCannulasCell NucleusCodeCognitiveComplexConditionConsciousConsumptionCorpus striatum structureDataDecision MakingDesire for foodDiabetes MellitusDiseaseEatingEconomic FactorsEmotionalEpidemicFatty acid glycerol estersFeeding behaviorsFoodGene ExpressionGenetic Predisposition to DiseaseGlutamate ReceptorGlutamatesHomeostasisHumanHypothalamic structureImmunohistochemistryIn Situ HybridizationIndividualIngestionInsulinIntakeInvestigationLateralLeptinLife StyleLinkMapsMeasurementMedialMetabolic ControlMethodologyMolecularMotivationMotorNamesNeuronsNeurosecretory SystemsNucleus AccumbensNumbersObesityOpioidOpioid PeptideOutputOverweightPathway interactionsPatternPeripheralPlayPopulationPrefrontal CortexProsencephalonPublic HealthRattusRecruitment ActivityRegulationResearchRewardsRiskRoleStrokeStructureStructure of nucleus infundibularis hypothalamiSucroseSystemTestingUnited StatesVentral StriatumWorkcancer typecognitive controldesireendogenous opioidsenergy balanceexecutive functionfeedinggamma-Aminobutyric Acidghrelinhypertensive heart diseasehypocretinimmunocytochemistryinterestneural circuitneuropeptide Ypreproenkephalinreceptorrelating to nervous systemresearch studyresponsetheoriestrend
项目摘要
DESCRIPTION (provided by applicant): Obesity is currently one of the major public health problems in the United States. Over 65% of the U.S. adult population is overweight. Obesity puts individuals at considerable risk for many disorders, such as heart disease, hypertension, diabetes, stroke, and certain types of cancer. Although there are a number of complex factors contributing to this trend, such as genetic predisposition, inactivity, lifestyle changes, and economic factors, the abundance and over consumption of calorically dense foods such as fats and sweets is largely responsible. Ingestion of food is required for survival, yet overabundance of energy-dense food has led to conditions that actually threaten survival. In the past decade, specific brain and peripheral systems involved in appetite control, particularly within the hypothalamus, have been discovered and characterized. However, relatively little is known about how brain networks involved in emotional regulation, executive function, and conscious control of behavior interact with hypothalamic energy balance-sensing systems. This would seem an important area of obesity research, as cognitive control, decision-making, and modulation of emotional responses in relation to the desire to eat are major determinants for the control of appetite in humans. Our work focuses on the role of the nucleus accumbens, a region within the ventral striatum, in the control of food motivation and food reward. We have shown that two main systems, one governed by endogenous opioid peptides and one by amino acid (GABA and glutamate) receptors, control certain aspects of ingestive behavior via connections with the lateral hypothalamus and other forebrain and brainstem regions. We aim to expand these investigations to study how cortical systems (i.e. the amygdala, gustatory cortex and prefrontal cortex) interact with ventral striatum and hypothalamus in the regulation of ingestive behavior. We will employ behavioral, pharmacological, neuroanatomical and molecular methodologies to address this question within an integrated, interdisciplinary framework.
描述(由申请人提供):肥胖是目前美国主要的公共卫生问题之一。超过 65% 的美国成年人超重。肥胖使人面临罹患许多疾病的相当大的风险,例如心脏病、高血压、糖尿病、中风和某些类型的癌症。尽管造成这一趋势的因素有很多,例如遗传倾向、缺乏运动、生活方式的改变和经济因素,但脂肪和甜食等高热量食物的丰富和过度消费是主要原因。生存需要摄入食物,但过多的高能量食物已经导致了实际上威胁生存的状况。在过去的十年中,人们发现并描述了参与食欲控制的特定大脑和外周系统,特别是下丘脑内的系统。然而,对于涉及情绪调节、执行功能和行为意识控制的大脑网络如何与下丘脑能量平衡传感系统相互作用,人们知之甚少。这似乎是肥胖研究的一个重要领域,因为与进食欲望相关的认知控制、决策和情绪反应调节是人类食欲控制的主要决定因素。我们的工作重点是伏隔核(腹侧纹状体内的一个区域)在控制食物动机和食物奖励中的作用。我们已经证明,两种主要系统,一种由内源性阿片肽控制,另一种由氨基酸(GABA 和谷氨酸)受体控制,通过与外侧下丘脑以及其他前脑和脑干区域的连接来控制摄取行为的某些方面。我们的目标是扩大这些研究范围,研究皮质系统(即杏仁核、味觉皮层和前额叶皮层)如何与腹侧纹状体和下丘脑相互作用来调节摄入行为。我们将采用行为、药理学、神经解剖学和分子方法在一个综合的跨学科框架内解决这个问题。
项目成果
期刊论文数量(0)
专著数量(0)
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BRIAN A BALDO其他文献
BRIAN A BALDO的其他文献
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{{ truncateString('BRIAN A BALDO', 18)}}的其他基金
Characterizing the Cocaine-responsive peptidome in mammalian telecephalon
哺乳动物端脑可卡因反应肽组的表征
- 批准号:
9036371 - 财政年份:2015
- 资助金额:
$ 24.14万 - 项目类别:
Prefrontal cortex-hypothalamus interactions and feeding
前额皮质-下丘脑相互作用和进食
- 批准号:
7540994 - 财政年份:2007
- 资助金额:
$ 24.14万 - 项目类别:
Frontal cortical opioid modulation of striato-hypothalamic networks: roles in food-reward and impulsivity
纹状体下丘脑网络的额叶皮质阿片类药物调节:在食物奖励和冲动中的作用
- 批准号:
9098786 - 财政年份:2007
- 资助金额:
$ 24.14万 - 项目类别:
Prefrontal cortex-hypothalmus interactions and feeding
前额皮质-下丘脑相互作用和进食
- 批准号:
8006417 - 财政年份:2007
- 资助金额:
$ 24.14万 - 项目类别:
Prefrontal cortex-hypothalmus interactions and feeding
前额皮质-下丘脑相互作用和进食
- 批准号:
7754426 - 财政年份:2007
- 资助金额:
$ 24.14万 - 项目类别:
Prefrontal cortex-hypothalmus interactions and feeding
前额皮质-下丘脑相互作用和进食
- 批准号:
7340470 - 财政年份:2007
- 资助金额:
$ 24.14万 - 项目类别:
Prefrontal cortex-hypothalamus interactions and feeding
前额皮质-下丘脑相互作用和进食
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- 资助金额:
$ 24.14万 - 项目类别:
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$ 24.14万 - 项目类别:
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6062425 - 财政年份:2000
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