Studies in Children with Digestive Disorders

消化系统疾病儿童的研究

• 批准号: 7896908
• 负责人: MELVIN B. HEYMAN
• 金额: $ 4.98万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-01 至 2010-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7896908
• 关键词: Acculturation; Adult; Age-Years; Area; Basic Science; Biography; California; Child; Child Nutrition; Childhood; Chinese American; Clinical; Clinical Investigator; Clinical Research; Clinical Trials; Collaborations; Data; Development; Digestive System Disorders; Disease; Eating Behavior; Educational process of instructing; Enrollment; Environment; Environment Design; Environmental Exposure; Epidemiology; Etiology; Event; Fostering; Future; Gastroenterology; Goals; Hispanics; Infant; Inflammatory Bowel Diseases; Investigation; Knowledge; Latino; Manuscripts; Measurement; Mentors; Methodology; Mid-Career Clinical Scientist Award (K24); Midcareer Investigator Award in Patient-Oriented Research; Modeling; Natural History; Obesity; Oral; Patients; Postdoctoral Fellow; Publications; Quality of life; Research; Research Personnel; Research Project Grants; Research Training; San Francisco; Scholarship; School-Age Population; Structure; Supervision; Training Programs; Translational Research; Universities; base; career; cohort; demographics; design; experience; interest; mother nutrition; nutrition; pediatric department; posters; programs; treatment strategy

DESCRIPTION (provided by applicant): This application to renew my K24 Midcareer Investigator Award in Patient-Oriented Research is based on research and teaching programs in pediatric inflammatory bowel disease (IBD) and pediatric nutrition at the University of California in San Francisco. Large cohorts of pediatric IBD patients are available at UCSF, augmented via collaborations with the Pediatric IBD Consortium in other IBD centers across the USA and within California. Ongoing IBD investigations include studies of the etiology of IBD utilizing the pediatric patient as a model for environmental exposures much less impacted by extraneous events compared with adults, the natural history of IBD beginning in childhood, particularly in those under six years of age, development of new strategies for treatment of pediatric IBD, and measurement of the quality of life in these subjects. Projects relating to pediatric nutrition focus on two main themes: assessing the influences of maternal nutrition knowledge and acculturation in Latino/Hispanic and Chinese-American children, taking advantage of the multi-ethnic demographics in the San Francisco Bay area to study development of eating behaviors and obesity in infants, young children and school age children. The influence of nutrition in various disease states is also under investigation. Trainees interested in pediatric gastroenterology and nutrition is encouraged to become directly involved in these clinical research training opportunities. The mentoring plan utilizes these projects to attract young investigators into the NIH-supported Research Training Program in Pediatric Gastroenterology and Nutrition (T32 DK 007762-28, PI Heyman). Structured mentoring is made available under my guidance, and trainees may enroll in coursework in the UCSF Masters in Clinical Research mentoring program that provides a well-designed environment for integration of epidemiological and biostatistical methodologies into clinical investigations. Additionally, trainees are provided with guidance and supervision by the Department of Pediatrics Scholarship Oversight Committee, which assures appropriate levels of mentoring and academic progress for the trainees. Trainees under my direct supervision are encouraged and assisted in designing and implementing research projects, analyzing resultant data, organizing oral/poster presentations, and preparing manuscripts for publication. In this enriched environment, trainees are stimulated to prepare for academic careers. The K24 award provides me with essential support for these educational and investigational efforts.

描述（由申请人提供）： 这份续签我的 K24 职业中期研究员以患者为导向的研究奖的申请是基于旧金山加利福尼亚大学儿科炎症性肠病 (IBD) 和儿科营养学的研究和教学项目。 UCSF 提供大量儿科 IBD 患者，并通过与美国和加利福尼亚州其他 IBD 中心的儿科 IBD 联盟的合作来扩大规模。正在进行的 IBD 研究包括利用儿科患者作为环境暴露模型来研究 IBD 的病因学，与成人相比，受外部事件的影响要小得多，IBD 的自然史始于儿童期，特别是在六岁以下的儿童中，IBD 的发展治疗儿科 IBD 的新策略以及测量这些受试者的生活质量。与儿科营养相关的项目重点关注两个主题：评估母亲营养知识和文化适应对拉丁裔/西班牙裔和华裔美国儿童的影响，利用旧金山湾地区的多种族人口统计数据来研究饮食行为的发展以及婴儿、幼儿和学龄儿童的肥胖。营养对各种疾病状态的影响也在研究中。我们鼓励对儿科胃肠病学和营养学感兴趣的学员直接参与这些临床研究培训机会。指导计划利用这些项目吸引年轻研究人员参加 NIH 支持的儿科胃肠病学和营养研究培训计划（T32 DK 007762-28，PI Heyman）。在我的指导下提供结构化指导，学员可以报名参加加州大学旧金山分校临床研究硕士指导项目的课程，该项目为将流行病学和生物统计方法整合到临床研究中提供了精心设计的环境。此外，儿科奖学金监督委员会为学员提供指导和监督，确保学员获得适当水平的指导和学术进步。在我直接监督下的学员被鼓励和协助设计和实施研究项目、分析结果数据、组织口头/海报演示以及准备出版手稿。在这个丰富的环境中，学员被激励为学术生涯做好准备。 K24 奖为我的这些教育和研究工作提供了必要的支持。