Studies in Children with Digestive Disorders

消化系统疾病儿童的研究

• 批准号: 6777065
• 负责人: MELVIN B. HEYMAN
• 金额: $ 12.88万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-07-01 至 2007-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6777065
• 关键词: Crohn' s disease; children; diet therapy; digestive disorder; human subject; human therapy evaluation; nutrition disorders; nutrition related tag; patient oriented research; pediatrics; reflux esophagitis; ulcerative colitis

Clinical research in pediatric disorders is essential to ensure advances in the management, prognosis and quality of life of infants, children and adolescents with these problems. The goals are (1) to foster a program in hypothesis-driven, expert clinical research in pediatric gastroenterology and nutrition, (2) to mentor young clinicians in pediatric gastroenterology and nutrition research, and (3) to promote ongoing interactions and collaborations with clinical investigators. To achieve these goals, current projects and future investigations of gastrointestinal and nutrition problems in pediatric patients will be conducted by trainees at various levels under the guidance and supervision of Dr. Heyman and his collaborators. Studies involving pediatric patients with inflammatory bowel disease (Crohn's disease and ulcerative colitis), HIV infection, familial adenomatous polyposis syndrome (with FAP gene mutations), ichthyosis erythrodermas with poor nutrition, and gastroesophageal reflux disease are currently ongoing or planned utilizing the facilities and staffs of the Pediatric Gastroenterology/Nutrition Clinics and the Pediatric Clinical Research Center at the University of California, San Francisco (UCSF). A cohort study is in the planning stage to determine whether nutrition advice promotes improved long-term outcomes in eating behaviors and health status (e.g., micronutrient adequacy; and growth parameters). The overriding objective of this proposal is to motivate and inspire young clinicians embarking on careers focused on clinically oriented research. Pediatric gastroenterology trainees will be instructed in the proper conduct of perspective randomized controlled clinical trials in infants, children, and adolescents. Trainees will also participate in didactic courses covering clinical trial design and procedure, protocol writing, data management, and ethical considerations. This award will enhance the applicant's ability to devote more time to research- related activities, and to provide guidance and instruction for trainees advancing towards productive scientific careers.

儿科疾病的临床研究对于确保患有这些问题的婴儿、儿童和青少年的管理、预后和生活质量的进步至关重要。目标是 (1) 促进儿科胃肠病学和营养学方面的假设驱动的专家临床研究计划，(2) 指导儿科胃肠病学和营养研究的年轻临床医生，以及 (3) 促进与临床的持续互动和合作调查人员。 为了实现这些目标，目前的项目和未来对儿科患者胃肠道和营养问题的研究将由各级学员在海曼博士及其合作者的指导和监督下进行。 目前正在或计划利用设施和人员开展涉及炎症性肠病（克罗恩病和溃疡性结肠炎）、HIV 感染、家族性腺瘤性息肉病综合征（FAP 基因突变）、营养不良的红皮鱼鳞病和胃食管反流病儿童患者的研究加州大学旧金山分校 (UCSF) 儿科胃肠病学/营养诊所和儿科临床研究中心。 一项队列研究正处于规划阶段，以确定营养建议是否有助于改善饮食行为和健康状况（例如微量营养素充足性和生长参数）的长期结果。该提案的首要目标是激励和启发年轻的临床医生从事以临床为导向的研究的职业生涯。 儿科胃肠病学学员将接受指导，如何在婴儿、儿童和青少年中正确进行前瞻性随机对照临床试验。 学员还将参加涵盖临床试验设计和程序、方案编写、数据管理和伦理考虑的教学课程。 该奖项将增强申请人投入更多时间从事研究相关活动的能力，并为学员迈向富有成效的科学职业提供指导和指导。