Characterizing Human Exceptional Longevity

人类超长寿命的特征

• 批准号: 7913647
• 负责人: THOMAS T PERLS
• 金额: $ 7.17万
• 依托单位: BOSTON MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-15 至 2011-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7913647
• 关键词: Activities of Daily Living; Age; Aging; American; Award; Behavioral Genetics; Bioethics; Cardiovascular Diseases; Cardiovascular system; Centenarian; Clinical; Clinical Investigator; Clinical Research; Clinical Trials; Collection; Communities; Data; Diabetes Mellitus; Disease; Education; Enrollment; Ensure; Epidemiologic Studies; Epigenetic Process; Faculty; Family; Family Study; Family member; Funding; Future; Generations; Genetic; Genetic Materials; Geriatrics; Goals; Grant; Hand; Health; Human; Individual; K-Series Research Career Programs; Life; Lipids; Longevity; Medical Students; Mentors; Mentorship; Molecular Genetics; New England; Nuclear Family; Paper; Pattern; Personality; Phenotype; Physicians; Prevalence; Probability; Protocols documentation; Public Health; Publishing; Qualifying; Recruitment Activity; Recurrence; Religion; Research; Research Personnel; Resources; Risk; Schools; Scientist; Siblings; Site; Spirituality; Staging; Stroke; Students; Survivors; Training Programs; Translating; United States National Institutes of Health; age related; base; career; career development; cohort; coping; disability; end of life; experience; genetic association; genetic epidemiology; genetic linkage; genetic pedigree; member; offspring; patient oriented research; population based; pre-doctoral; professor; repository; segregation; transmission process

This is a revised application for a Mid-Career Investigator Award in Patient-Oriented Research (K24). The applicant, Dr. Thomas Perls, is an Associate Professor of Medicine and Geriatrics and Founder and Director of the New England Centenarian Study. Having received an NIH physician scientist award (K-12) and a Paul Beeson Faculty Scholar in Aging Research Award, Dr. Perls proceeded to become an independent scientist devoted to patient-oriented research. Specifically, through these earlier mentored awards, Dr. Perls developed expertise in conducting a population-based phenotypic study of an extremely old cohort. His independence is demonstrated by his receipt of four other NIH grants (RO-3, R-21 and two R0-1s). Dr. Perls has a substantial record of mentoring students and clinical investigators at various stages of their careers. He has mentored five American Federation of Aging Research Medical Student Geriatrics Scholars, three premedical and pre-graduate school students, two geriatrics fellows, a pre-doctoral fellow and an Assistant Professor in Geriatrics. All of these trainees successfully published papers with Dr. Perls. While carrying out the aims of his R01-funded study, a population-based bio-demographic study of centenarians and their families, this K24 grant provides that 15% effort will be devoted to gathering preliminary data and developing applications to fund a genetic epidemiological study of centenarians. Dr. Perls will attend courses in bioethics, responsible conduct of clinical investigations and genetic epidemiology as a part of his career development-related education goals. These centenarian studies provide fertile ground for mentees to gain hands-on experience in clinical research. Innumerable aspects of exceptional longevity are available for study from spirituality, personality, adaptive capacity and functional reserve, to demographic and clinical observations to epigenetic associations. 35% effort will be dedicated to mentoring established and future mentees. A large and diverse academic community with a broad spectrum of training programs will ensure an ample pool of highly qualified and talented mentees. Relevance to public health: The study of human exceptional longevity under Dr. Perls's mentorship, provides trainees, from students to junior faculty, fertile ground for studying a broad range of aspects of successful aging from religion, personality, adaptive capacity and functional reserve to environmental, behavioral and genetic associations with exceptional survival. Subsequent findings may ultimately translate into strategies that help people age more successfully.

这是针对患者研究（K24）的中期研究员奖的修订申请。这 申请人托马斯·佩尔斯（Thomas Perls）博士是医学和老年医学副教授，创始人兼董事 新英格兰一百派研究。获得了NIH医师科学家奖（K-12）和保罗之后 贝森（Beeson）老龄化研究奖学者，佩尔斯（Perls）博士开始成为一名独立科学家 致力于以患者为导向的研究。具体而言，通过这些早期的指导奖，Perl博士 在进行一个非常古老的队列的基于人群的表型研究方面发展了专业知识。他的 他收到了其他四项NIH赠款（RO-3，R-21和两个R0-1）来证明独立。珀尔博士 在职业生涯的各个阶段都有指导学生和临床研究人员的大量记录。 他指导了五个美国衰老研究医学生老师学者联合会，三个 学科和学龄前的学生，两个老年研究员，一名博士后研究员和一名助理 老年医学教授。所有这些受训者都成功地与Perls博士发表了论文。执行 他的R01资助研究的目的是一项基于人群的生物人口统计学研究 家庭，这项K24赠款规定，15％的努力将致力于收集初步数据并制定 资助百岁老人遗传流行病学研究的应用。佩尔斯博士将参加课程 生物伦理学，负责任的临床研究和遗传流行病学作为他职业生涯的一部分 与发展相关的教育目标。这些百年研究为受训者提供了肥沃的基础 临床研究的动手经验。可用于无数寿命的无数方面可用于 从灵性，个性，适应能力和功能储备从人口统计和临床研究中进行研究 对表观遗传关联的观察。 35％的努力将致力于指导建立和未来 受训者。一个拥有广泛培训计划的大型多样化的学术界将确保 足够的高素质和才华横溢的受训者。 与公共卫生有关：在佩尔斯博士的指导下对人类特殊寿命的研究，提供 从学生到初级教师，学员，肥沃的基础，用于学习成功的广泛方面 宗教，个性，适应能力和功能储备从环境，行为和 具有特殊生存的遗传关联。随后的发现可能最终转化为策略 这可以帮助人们更成功。