Osteopathic Manipulative Medicine in Pregnancy: Physiologic and Clinical Effects

妊娠整骨手法医学：生理和临床效果

• 批准号: 7846941
• 负责人: KENDI LEE HENSEL
• 金额: $ 10.8万
• 依托单位: UNIVERSITY OF NORTH TEXAS HLTH SCI CTR
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-30 至 2012-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7846941
• 关键词: Address; Adverse effects; Affect; Amniotic Fluid; Back; Back Pain; Biomechanics; Blinded; Case Study; Child; Classification; Clinical; Clinical Trials; Data; Diagnosis; Edema; Educational process of instructing; Equilibrium; Fetus; Force of Gravity; Gait; Health; Hip region structure; Incidence; Individual; Intervention; Investigation; Labor Complications; Lead; Leg; Life; Liquid substance; Lordosis; Low Back Pain; Lower Extremity; Measurement; Meconium; Medical Students; Medicine; Methods; Modality; Modeling; Mothers; Motion; Musculoskeletal System; Osteopathic Medicine; Outcome; Pain; Participant; Patients; Pelvis; Peripheral; Philosophy; Physiological; Placebo Control; Pregnancy; Pregnancy Outcome; Pregnancy Trimesters; Premature Labor; Prenatal care; Publishing; Randomized; Regulation; Reporting; Research Personnel; Staining method; Stains; Testing; Third Pregnancy Trimester; Uterus; Woman; base; body system; clinical effect; design; fetal; functional status; hemodynamics; improved; indexing; pregnant; prenatal; prenatal stress; programs; theories

DESCRIPTION (provided by applicant): Osteopathic manipulative medicine (OMM) is a complementary and alternative body-based treatment method in which the patient is evaluated and treated including the musculoskeletal system to improve physiologic functioning and remove impediments to optimal health and functioning. During pregnancy, a woman's body is challenged by significant and extensive physiological and biomechanical changes that impact all her body systems and all aspects of her life. Many of these changes are reflected in her musculoskeletal system, and are able to be affected by OMM. This proposal will investigate the efficacy and hypothesized physiological mechanisms by which OMM affects selected conditions related to pregnancy, labor and delivery by conducting three studies over five years. Study One will address the efficacy of adjunctive OMM therapy during 3rd trimester of pregnancy in improving several clinical outcomes whereas Studies Two and Three will address potential physiological and biomechanical mechanisms that may contribute to these clinical benefits. Study hypotheses and aims include: Study One Hypothesis OMM improves selected clinical outcomes in pregnancy. Aim: To determine if OMM can decrease low back pain in the pre and post-partum period Aim: To determine if OMM can improve functional status in the pre and post-partum period Aim: To determine if OMM can decrease the incidence of meconium-stained amniotic fluid in labor and delivery as an index of fetal stress Study Two Hypothesis Physiological changes related to improved autonomic and peripheral hemodynamic regulation are, in part, responsible for the hypothesized clinical effects of OMM in Study One. Aim: To examine how OMM affects autonomic balance during pregnancy, Aim: To determine how OMM impacts lower extremity edema in the third trimester of pregnancy Study Three Hypothesis Biomechanical changes related to improved gait are, in part, responsible for the hypothesized clinical effects of OMM in Study One. Aim: To evaluate functional and biomechanical changes in gait in the third trimester of pregnancy, and how OMM may affect gait. These 3 studies will use a placebo-controlled, randomized, blinded design to test the impact of the OMM intervention on the selected outcomes. If OMM is found to be efficacious in the treatment of the selected outcomes of pregnancy, labor, and delivery, it should be considered a complementary part of routine prenatal care as a way to improve maternal-fetal health.

描述（由申请人提供）：整骨疗法操纵医学（OMM）是一种互补和替代性的基于身体的治疗方法，对患者进行评估和治疗，包括肌肉骨骼系统，以改善生理功能，并消除对最佳健康和功能的障碍。在怀孕期间，女性的身体受到重大且广泛的生理和生物力学变化的挑战，这些变化影响了她的所有身体系统以及生活的所有方面。这些变化中的许多变化反映在她的肌肉骨骼系统中，并且能够受OMM的影响。该建议将通过在五年内进行三项研究来研究效果和假设的生理机制，从而影响与怀孕，劳动和分娩有关的条件。研究将解决辅助性OMM疗法在妊娠三个月改善几个临床结果方面的疗效，而研究将解决可能有助于这些临床益处的潜在生理和生物力学机制。研究假设和目的包括：研究一种假设，改善了妊娠中选定的临床结果。目的：确定OMM是否可以减轻产前和后期期间的腰痛，目的是：确定OMM是否可以改善产前和后产后的功能状态：确定OMM是否可以降低洞穴的发生率作为胎儿压力研究指数研究指标的羊水染色的羊水两种假设生理变化与改善的自主和外周血液动力学调节有关，部分原因是OMM在研究中的假设临床效应。目的：要研究怀孕期间的OMM如何影响自主平衡，目的：确定妊娠三个月中的官员如何影响下肢水肿研究三种假设的生物力学变化与改善步态有关在研究中。目的：评估妊娠三个月步态的功能和生物力学变化，以及OMM如何影响步态。这三项研究将使用安慰剂对照，随机，盲目的设计来测试OMM干预对所选结果的影响。如果发现OMM可以有效地治疗妊娠，劳动和分娩的选定结果，则应将其视为常规产前护理的互补部分，是改善母亲养育健康的一种方式。