Basic Science Research in Digestive Diseases

消化系统疾病基础科学研究

• 批准号: 7630676
• 负责人: MARK DONOWITZ
• 金额: $ 37.28万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1989
• 资助国家: 美国
• 起止时间: 1989-09-30 至 2014-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7630676
• 关键词: Basic Science; Digestive System Disorders; Research

DESCRIPTION (provided by applicant): This is a renewal application for a Training Grant (TG) in Gl at the Johns Hopkins Univ. School of Medicine for the training of postdoctoral fellows (MD, MD/PhD or PhD) for long-term investigative careers in basic and translational investigation in Gastroenterology. This program has strong basic science investigators in the Gl Division; a formal 4 year program for training translational/clinical investigators done in collaboration with the Hopkins School of Public Health which usually results in a PhD. in clinical research; close interactions with Basic Scientists at Hopkins; a closely knit group of scientists interested in epithelial cell and molecular biology, IBD, epigenetics of Gl cancer; an NIDDK Core Center Grant (Hopkins Digestive Diseases Basic Research Development Core Center); and a PPG on trafficking in epithelial cells The TG faculty (28) have primary appointments in the Gl Division (16); Departments of Cell Biology (1);Physiology (2); Biological Chemistry (1); other Dept. of Medicine (2); Pathology (1); Oncology (2); Surgery(1); Pediatrics (1); Genetics (1). The Hopkins Gl Division has several areas of expertise for research training of fellows both in basic research and clinical research. In BASIC RESEARCH, these center around intestinal and hepatic molecular, cell biologic, genetic and physiologic studies of epithelial transport epithelial polarization, differentiation, and trafficking of membrane proteins, actions of bacterial enterotoxins, IBD (genetics, proteomics, role of luminal bacteria, role of microRNAs, disease models), hepatic collagen formation, cytokines in hepatic regeneration and steatosis, genes activated in pancreatic cancer and epigenetics and biomarker discovery of Gl cancer. In CLINICAL RESEARCH, these center on proteomics of IBD biomarker discovery in Gl cancer and IBD, confocal endoscopy in Gl disease, bariatric surgery, and photodynamic therapy in treatment of esophageal cancer. A total of 5 Training Grant slots are requested per year to be used for 3-5 MD or MD/PhD and/or 1 or 2 PhD fellows. The program is for 2-3years in the laboratory or 3 years of clinical research leading to a PhD.. in addition to a clinical year not supported by the TG. New programs are requested for basic research in Pediatric Gl (1 position) and a predoctoral program to train future basic science faculty who do basic science Gl related research (1position). All Fellows are assigned a Fellowship Committee to monitor their progress in attaining a long-term investigative career. Fellows who are thought to be successful in being prepared for investigative careers are helped to apply for K Awards and brought on as junior faculty to continue career development. PUBLIC HEALTH RELEVANCE: This grant will allow the training of leaders of Gl research, both basic and translational research.

描述（由申请人提供）： 这是约翰·霍普金斯大学 Gl 培训补助金 (TG) 的续签申请。医学院为博士后研究员（医学博士、医学博士/哲学博士或博士）提供胃肠病学基础和转化研究的长期研究职业培训。该项目在 GL 部门拥有强大的基础科学研究人员；与霍普金斯公共卫生学院合作完成的为期 4 年的正式计划，用于培训转化/临床研究人员，通常会获得博士学位。临床研究；与霍普金斯大学的基础科学家密切互动；一个由对上皮细胞和分子生物学、IBD、胃肠癌表观遗传学感兴趣的紧密联系的科学家组成的小组； NIDDK 核心中心资助（霍普金斯消化疾病基础研究发展核心中心）； TG 教员 (28) 在 GI 部门 (16) 担任主要职务；细胞生物学系（1）；生理学系（2）；生物化学（1）；其他医学系（2）；病理学 (1);肿瘤学(2)；手术(1)；儿科(1)；遗传学（1）。霍普金斯大学 GL 部门拥有多个专业领域，可对基础研究和临床研究的研究员进行研究培训。在基础研究中，这些研究围绕肠和肝分子、细胞生物学、上皮运输的遗传和生理学研究、上皮极化、分化和膜蛋白的运输、细菌肠毒素的作用、IBD（遗传学、蛋白质组学、管腔细菌的作用、作用） microRNA、疾病模型）、肝胶原形成、肝再生和脂肪变性中的细胞因子、胰腺癌中激活的基因以及胃肠道癌的表观遗传学和生物标志物发现。在临床研究中，这些研究集中在胃肠道癌和IBD中IBD生物标志物发现的蛋白质组学、胃肠道疾病中的共聚焦内窥镜检查、减肥手术以及食道癌治疗中的光动力疗法。每年总共请求 5 个培训补助金名额，用于 3-5 名医学博士或医学博士/博士和/或 1 或 2 名博士研究员。该计划包括 2-3 年的实验室工作或 3 年的临床研究，以获得博士学位。此外还有 TG 不支持的临床年。需要新的儿科 GL 基础研究项目（1 个职位）和博士前项目，以培训从事基础科学 GL 相关研究的未来基础科学教师（1 个职位）。所有研究员都被分配了一个研究员委员会来监督他们在实现长期调查生涯方面的进展。那些被认为成功为调查职业做好准备的研究员将被帮助申请 K 奖，并被提拔为初级教师以继续职业发展。 公共卫生相关性：这笔赠款将用于培训基础研究和转化研究的领导者。